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Myo-Inositol

supporting metabolic and reproductive health

nutrient
Evidence · Grade C
Meta-analysis availableSystematic review availableHuman trial evidenceTraditional use

Myo-inositol is a naturally occurring inositol compound involved in cellular signaling. It has been studied with selenium in autoimmune thyroiditis and subclinical hypothyroidism contexts, but the evidence remains limited.

Myo-inositol participates in intracellular signaling pathways, including pathways relevant to TSH signaling. Some studies have evaluated myo-inositol combined with selenium in people with autoimmune thyroiditis or subclinical hypothyroidism. It should be categorized as an emerging supportive compound rather than an established Hashimoto's remedy.

Quick answer

What it is: Myo-inositol participates in intracellular signaling pathways, including pathways relevant to TSH signaling.

May support:Prediabetes, OCD, Insulin Resistance, PMDD, Hashimoto's Thyroiditis, PMS, Autoimmune Thyroid Disease, PCOS

Evidence:Evidence · Grade C

Evidence Summary

Evidence · Grade C

The current evidence grade for myo-inositol is based on established biochemical roles and a growing body of research, primarily from in vitro studies, animal models, and human clinical trials, particularly in areas like polycystic ovary syndrome (PCOS) and insulin resistance. However, specific evidence for its role in Hashimoto's Thyroiditis is currently limited or not yet established in the provided studies.

Last reviewed · Jun 2026

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Why It Works

May support cellular signaling pathways involved in TSH receptor signaling and metabolic regulation. In thyroid contexts, it is usually studied together with selenium rather than as a stand-alone intervention.

How it works in more detail

Myo-inositol is a key component of the phosphatidylinositol cycle, which generates inositol triphosphate (IP3) and diacylglycerol (DAG) secondary messengers. These messengers are crucial for signal transduction pathways, including those initiated by insulin, follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH). It is involved in glucose uptake, cell proliferation, and neurotransmitter modulation. Myo-inositol also contributes to the synthesis of phospholipids, which are essential components of cell membranes.

How to use

Always consult a qualified clinician.

Editorial guidance

Suggested dosage
Common study protocols often use myo-inositol in gram-level dosing, frequently paired with selenium. Dosing should be guided by product labeling and clinician input.
Frequency
Twice daily (morning and evening)
With or without food
With food

Taken with meals to pair insulin-sensitizing action with post-prandial glucose load and reduce mild GI upset.

Commonly combined with
  • D-Chiro-Inositol · 40:1 (myo:DCI)

    Restores the physiologic plasma ratio; combined therapy outperforms either alone for PCOS ovulation, androgens, and insulin sensitivity.

    Systematic review
Typical forms
Powder, Capsules, Combination products with selenium
Quality markers
When purchasing myo-inositol, look for products that are third-party tested for purity and potency. Ensure the product specifies 'myo-inositol' as the primary ingredient, as other inositol isomers exist. Reputable brands often provide certificates of analysis.
Avoid if
  • Pregnancy without clinician guidance
  • Use alongside complex endocrine treatment without clinician guidance

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Suggested dosage

Common study protocols often use myo-inositol in gram-level dosing, frequently paired with selenium. Dosing should be guided by product labeling and clinician input.

Active medicinal compounds

Myo-inositol is the primary active compound.

Traditional use

While myo-inositol itself is a biochemical compound, foods rich in inositol (like whole grains and legumes) have been part of traditional diets for centuries. However, there is no specific traditional medicinal use of isolated myo-inositol as a remedy in historical systems.

Safety

Safety warnings

Generally well tolerated in many studies, but gastrointestinal discomfort can occur. People who are pregnant, taking medications, or managing endocrine disorders should discuss use with a clinician.

Avoid if

  • Pregnancy without clinician guidance
  • Use alongside complex endocrine treatment without clinician guidance

Reported side effects

  • GI discomfort
  • Nausea
  • Headache

Evidence ecosystem

Scientific literature, clinical guidance, government sources, ongoing research, traditional use, and lived experience — grouped by source type and quality.

Overall grade (C)

The current evidence grade for myo-inositol is based on established biochemical roles and a growing body of research, primarily from in vitro studies, animal models, and human clinical trials, particularly in areas like polycystic ovary syndrome (PCOS) and insulin resistance. However, specific evidence for its role in Hashimoto's Thyroiditis is currently limited or not yet established in the provided studies.

Filter by source type

Meta-Analyses(4)

Pooled analyses across multiple human trials.

Very High Quality
  • Comparison of metformin with inositol versus metformin alone in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.

    Kelly FA, de Oliveira Macena Lôbo A, Cardoso JHCO, de Moraes FCA · Endocrine · 2025 · n=388

    Metformin was the first medication targeting insulin resistance in PCOS, and it has been extensively studied as a metabolic treatment option. In recent years, inositols have emerged as potential treatment options for PCOS, but confidence in the available evidence supporting their use is limited. We comprehensively searched PubMed, Embase, and Cochrane databases for RCTs comparing the use of combined metformin and inositol versus metformin alone in women with PCOS. A random-effects model was used to calculate the risk ratios (RRs) and mean differences (MDs) with 95% confidence intervals (CIs). A p-value of <0.05 was deemed as statistically significant. Six RCTs and 388 patients were included in the analysis, with follow-up ranging from 3 to 6 months. Combination therapy was significantly associated with improved menstrual cycle regularity (RR 1.56; 95% CI 1.01 to 2.41; p = 0.04), and lower values of modified Ferriman-Gallwey score (MD -0.97; 95% CI -1.53 to -0.40; p&#

    Meta-AnalysisPubMedVery High Quality
  • Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.

    Peng B, Wang W, Gu Q, Wang P, Teng W, Shan Z · Frontiers in endocrinology · 2024

    Clinicians often consider the use of dietary supplements to assist in lowering thyroid autoantibody titres in patients with Hashimoto's thyroiditis (HT). Currently, different supplements differ in their ability to reduce autoantibody levels. The purpose of this article is to compare the ability of different supplements to lower autoantibody titres and restore TSH levels through a systematic literature review. We obtained information from the PubMed, Web of Science, Embase, and Cochrane databases, as well as the China National Knowledge Infrastructure (CNKI). Selected studies included those using selenium, Vitamin D, Myo-inositol, and Myo-inositol in combination with selenium for the treatment of HT patients with euthyroidism. These data were combined using standardised mean differences (SMDs) and assessed using a random effects model. A total of 10 quantitative meta-analyses of case-control studies were selected for this meta-analysis. Compared to the placebo group, the use of selenium

    Meta-AnalysisPubMedVery High Quality
  • Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.

    Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J · Reproductive biology and endocrinology : RB&E · 2023 · n=1691

    Metformin is the gold standard insulin sensitizer, which is widely used to treat insulin resistance in polycystic ovary syndrome (PCOS). However, metformin may induce gastrointestinal side effects. Inositols have long been debated as a potential alternative for metformin in treating PCOS. Therefore, the present systematic review aimed to evaluate the efficacy and safety of inositols in treating PCOS. The present systematic search was performed in CENTRAL, MEDLINE, and Embase from the inception until October 20th, 2021. Eligible randomized controlled trials (RCTs) included women diagnosed with PCOS and compared any inositols with metformin or placebo. Our primary outcome was cycle normalization, whereas secondary outcomes were body mass index (BMI), parameters of carbohydrate metabolism and clinical and laboratory hyperandrogenism. Results are reported as risk ratios or mean differences (MDs) with 95% confidence intervals (CIs). Twenty-six RCTs were identified, including data of 1691

    Meta-AnalysisPubMedVery High Quality

Systematic Reviews(1)

Structured reviews of the full body of evidence (incl. Cochrane).

Very High Quality
  • Inositol and Non-Alcoholic Fatty Liver Disease: A Systematic Review on Deficiencies and Supplementation.

    Pani A, Giossi R, Menichelli D, Fittipaldo VA, Agnelli F, Inglese E · Nutrients · 2020

    Liver lipid accumulation is a hallmark of non-alcoholic fatty liver disease (NAFLD), broadly associated with insulin resistance. Inositols (INS) are ubiquitous polyols implied in many physiological functions. They are produced endogenously, are present in many foods and in dietary supplements. Alterations in INS metabolism seems to play a role in diseases involving insulin resistance such as diabetes and polycystic ovary syndrome. Given its role in other metabolic syndromes, the hypothesis of an INS role as a supplement in NAFLD is intriguing. We performed a systematic review of the literature to find preclinical and clinical evidence of INS supplementation efficacy in NAFLD patients. We retrieved 10 studies on animal models assessing Myoinosiol or Pinitol deficiency or supplementation and one human randomized controlled trial (RCT). Overall, INS deficiency was associated with increased fatty liver in animals. Conversely, INS supplementation in animal models of fatty liver reduced hepa

    Systematic ReviewPubMedVery High Quality

Randomized Human Trials(4)

Controlled human studies with random assignment.

High Quality
  • Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: an open-label, randomized controlled trial.

    Asimakopoulos G, Pergialiotis V, Antsaklis P, Theodora M, Loutradis D, Daskalakis G · Archives of gynecology and obstetrics · 2024

    Myo-inositol (MI) is an insulin-sensitizing dietary supplement, enhancing the transfer of glucose into the cell. Gestational diabetes mellitus (GDM) is characterized by abnormal glucose tolerance, which is associated with elevated insulin resistance. The present study aimed to assess the effect of MI supplementation during pregnancy on the incidence of GDM. We performed a single-center, open-label, randomized controlled trial. A cohort of 200 pregnant women at 11-13+6 weeks of gestation were randomly assigned in two groups: MI group (n = 100) and control group (n = 100). The MI group received MI and folic acid (4000 mg MI and 400 mcg folic acid daily), while the control group received folic acid alone (400 mcg folic acid daily) until 26-28 weeks of gestation, when the 75 g Oral Glucose Tolerance Test (OGTT) was performed for the diagnosis of GDM. Clinical and metabolic outcomes were assessed. The incidence of GDM was significantly higher in the MI group (1

    Randomized TrialPubMedHigh Quality
  • Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS).

    Fruzzetti F, Perini D, Russo M, Bucci F, Gadducci A · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2017

    Insulin resistance (IR) plays a pivotal role in PCOS. Insulin-sensitizer agents such as metformin and inositols have been shown to improve the endocrine and metabolic aspects of PCOS. The purpose of this study is to compare their effects on the clinical and metabolic features of the women with PCOS. Fifty PCOS women with IR and/or hyperinsulinemia were randomized to treatment with metformin (1500 mg/day) or myo-inositol (4 g/day). IR was defined as HOMA-IR >2.5, while hyperinsulinemia was defined as a value of AUC for insulin after a glucose load over the cutoff of our laboratory obtained in normal women. The Matsusa Index has been calculated. The women have been evaluated for insulin secretion, BMI, menstrual cycle length, acne and hirsutism, at baseline and after 6 months of therapy. The results obtained in both groups were similar. The insulin sensitivity improved in both treatment groups. The BMI significantly decreased and the menstrual cycle was normalized in abo

    Randomized TrialPubMedHigh Quality
  • Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto's patients with subclinical hypothyroidism.

    Nordio M, Basciani S · European review for medical and pharmacological sciences · 2017 · n=168

    Clinical evidence suggests that oral supplementation with myo-inositol (MI) and selenium (Se) is useful in the treatment of autoimmune thyroiditis. The purpose of this study was to highlight the positive response of Hashimoto's patients with subclinical hypothyroidism (SH) treated with MI and Se (MI-Se) in restoring a normal thyroid function. A total of 168 patients with Hashimoto's thyroiditis (HT) having Thyroid Stimulating Hormone (TSH) levels between 3 and 6 µIU/ml were randomized into 2 groups: one receiving MI-Se and the other one Se alone. TSH, anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels were significantly decreased in patients treated with combined MI-Se after six months of treatment. Also, a significant free serum T4 increase was observed in MI-Se group, along with an amelioration of patients' quality of life. The administration of MI-Se is significantly effective in decreasing TSH, TPOAb and TgAb levels, as well as in enhancing thyroid hormone

    Randomized TrialPubMedHigh Quality

Observational Studies(2)

Cohort, case-control, and cross-sectional human studies.

Moderate Quality
  • Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines.

    Fitz V, Graca S, Mahalingaiah S, Liu J, Lai L, Butt A · The Journal of clinical endocrinology and metabolism · 2024 · n=2230

    Insulin resistance is common in women with polycystic ovary syndrome (PCOS). Inositol may have insulin sensitizing effects; however, its efficacy in the management of PCOS remains indeterminate. To inform the 2023 international evidence-based guidelines in PCOS, this systematic review and meta-analysis evaluated the efficacy of inositol, alone or in combination with other therapies, in the management of PCOS. Medline, PsycInfo, EMBASE, All EBM, and CINAHL from inception until August 2022. Thirty trials (n = 2230; 1093 intervention, 1137 control), with 19 pooled in meta-analyses were included. Data were extracted for hormonal, metabolic, lipids, psychological, anthropometric, reproductive outcomes, and adverse effects by 1 reviewer, independently verified by a second. Thirteen comparisons were assessed, with 3 in meta-analyses. Evidence suggests benefits for myo-inositol or D-chiro-inositol (DCI) for some metabolic measures and potential benefits from DCI for ovulation, but inosito

    Observational StudyPubMedLow Quality
  • The Efficacy and Safety of Myo-inositol Supplementation for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women: A Systematic Review and Meta-Analysis.

    Factor PA, Corpuz H · Journal of the ASEAN Federation of Endocrine Societies · 2023 · n=887

    Myo-inositol has emerged as one of the preventive therapies for the development of gestational diabetes mellitus in at-risk populations. This systematic review and meta-analysis was conducted to determine the efficacy and safety of myo-inositol in decreasing the incidence of gestational diabetes in overweight and obese pregnant women. This meta-analysis was conducted using the standard Cochrane methodology and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 guidelines. Inclusion criteria were randomized controlled trials (RCTs) that enrolled overweight and obese pregnant women and used myo-inositol supplementation. The primary outcome was the incidence of gestational diabetes mellitus at 24-28 weeks. Secondary outcomes included cesarean section rate, the incidence of pregnancy-induced hypertension, macrosomia and preterm delivery. Risk ratios (RRs) and 95% confidence intervals (CIs) were used for dichotomous data. Six R

    Observational StudyPubMedLow Quality

Clinical Trial Registries(13)

Registered ongoing or completed trials (ClinicalTrials.gov).

Moderate Quality
  • Effects of Myo-inositol Plus Melatonin in Perimenopausal Women

    NCT01325389 · UNKNOWN · UNKNOWN

    Menopause is the milestone of a more broaden condition that can last up to 10 years. The first menopausal symptoms usually appear around the age of 42 and are characterized by a gradual decline in thyroid and gonadal function with a progressive increase of plasmatic luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels. Recent studies have shown that myo-inositol and melatonin play a major role in ovarian homeostasis. In particular, it has been demonstrated that myo-inositol and/or melatonin supplementation lead to an increase of oocyte quality. Additional studies focused on postmenopausal women have shown that myo-inositol is able to ameliorate the metabolic syndrome that often affects these patients, thus reducing the risk of cardiovascular diseases (CVDs). The aim of the present study is to evaluate whether myo-inositol and melatonin might play a positive role in regulating hormonal levels during menopausal onset.

    Clinical TrialClinicalTrials.govModerate Quality
  • Effect of Myoinositol on Serum Asprosin Levels in PCOS Patients

    n=30 · NCT05951309 · COMPLETED · COMPLETED

    Policystic ovary syndrome is the most common endocrinopthy during reproductive period. One of the factors implicated in the pathogenesis is insulin resistance. Asprosin, which is secreted from white adipose tissue is a new candidate for insulin resistance. Myoinositol is known to reduce insulin resistance in PCOS patients. The effect of myoinsitol on serum asprosin levels is unknown yet. This study aimed to evaluate the effect of myoinositol on serum asprosin levels in PCOS patients.

    Clinical TrialClinicalTrials.govModerate Quality
  • The LEADERSHIP 301 Trial: A 12-Week, Randomized, Multi-Center, Double-Blind, Placebo-Controlled, 3-Arm, Parallel-Group, Phase 3 Trial to Evaluate the Efficacy and Safety of 2 Doses of AQX-1125 Targeting the Src Homology 2-containing Inositol-5'-Phosphatase 1 (SHIP1) Pathway in Subjects With Interstitial Cystitis/Bladder Pain Syndrome Followed by an Extension Period

    n=433 · NCT02858453 · UNKNOWN · UNKNOWN

    This study evaluates the effects of two doses of oral AQX-1125 on bladder pain and other urinary symptoms in subjects with interstitial cystitis/bladder pain syndrome. Participants will receive either 100 mg AQX-1125, 200 mg AQX-1125 or placebo for the first 12 weeks of the study. After 12 weeks, all participants will receive either 100 mg or 200 mg AQX-1125 for 52 weeks.

    Clinical TrialClinicalTrials.govModerate Quality

Limitations: There is a lack of specific PubMed studies provided to directly support claims regarding myo-inositol's efficacy for Hashimoto's Thyroiditis. Therefore, any potential benefits for this condition are speculative based on broader understanding of myo-inositol's mechanisms rather than direct evidence.

Health Voice Perspectives

Independent of evidence grade

Approved mentions from health educators, physicians, and researchers across podcasts, videos, and articles. Educational context only — does not influence the scientific evidence rating above.

  • TH
    Tallene Hacatoryan· MS, RD, CLT — Registered Dietitian

    Recommends myo-inositol (typically combined with d-chiro-inositol in a 40:1 ratio) as a first-line supplement for PCOS to improve insulin sensitivity, ovulation, and androgen balance.

    "Inositol is one of the most well-studied supplements for PCOS — it helps your body use insulin more efficiently and supports more regular cycles."
    ·6/4/2026
  • TH
    Tallene Hacatoryan· MS, RD, CLT — Registered Dietitian

    Frames inositol as a metabolic tool for insulin resistance, not just a "PCOS supplement."

    "Inositol works on the same insulin pathway that metformin does — it's a gentler entry point for many women with insulin resistance."
    ·6/4/2026
  • DB
    Drew Baird· Personal Trainer; Founder, NOVUM PCOS Coaching

    Includes inositol as a core supplement in his PCOS coaching, paired with resistance training and a lower-glycemic diet.

    "Inositol plus lifting weights three times a week beats almost any "PCOS detox" protocol on Instagram — and there's actual evidence behind it."
    ·6/4/2026

This page is educational. Statements use phrases like "may support" and "has been studied for"because no remedy here is approved to cure, treat, or reverse any condition. Discussion happens on the ailment pages — community statistics here are derived from those reports. Always consult a qualified clinician.

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