RemedyAtlas
Back

Tongkat Ali + Fadogia Agrestis Stack

Supporting free testosterone, libido, and motivation in men with suboptimal androgen levels.

Evidence · Grade ASafety · Use with caution
Systematic review availableHuman trial evidenceTraditional useSafety cautionInteraction risk

A popularized stack pairing Tongkat Ali (Eurycoma longifolia) with Fadogia Agrestis, taken together to support endogenous testosterone, libido, and male hormonal health.

This combination has been popularized in the men's health community (notably by Dr. Andrew Huberman) as a daily stack aimed at supporting healthy testosterone levels. Tongkat Ali is proposed to free up testosterone by lowering SHBG and modestly raising luteinizing hormone, while Fadogia Agrestis is hypothesized to act more like an LH-mimetic to stimulate testicular testosterone production. Because Fadogia has very limited human safety data, the stack is typically cycled (3 weeks on / 1 week off) rather than taken continuously.

Quick answer

What it is: This combination has been popularized in the men's health community (notably by Dr.

May support:Hypogonadism (Low Testosterone)

Evidence:Evidence · Grade A

Safety:Safety · Use with caution

Evidence Summary

Evidence · Grade A

Tongkat Ali has a modest but reasonable body of human RCTs supporting effects on free testosterone, SHBG, and stress markers (Grade B individually). Fadogia Agrestis has essentially no human clinical trials — evidence is limited to rodent studies and anecdote. The combined stack itself has not been formally studied in humans, so the combined evidence grade is downgraded to C.

Last reviewed · Jun 2026

Have you tried Tongkat Ali + Fadogia Agrestis Stack?

Vote in 5 seconds. Add details if you want.

Your experience for Hypogonadism (Low Testosterone):

Commonly Combined With

Other remedies frequently used alongside this one — from curated relationships, community reports, and shared protocols.

Community signal breakdown

Where this remedy is being discussed across the web and community.

See Community Mentions

People Like Me insights

As more members share outcomes, RemedyAtlas will show which remedies helped people with similar conditions, symptoms, goals, and lab patterns.

Community Discussions

What people say about Tongkat Ali + Fadogia Agrestis Stack

Search on Reddit →

Latest News

Latest news on Tongkat Ali + Fadogia Agrestis Stack

More on Google News →

Health Videos

Health videos on Tongkat Ali + Fadogia Agrestis Stack

More on YouTube

Why It Works

Tongkat Ali reduces sex hormone binding globulin (SHBG), freeing bound testosterone, and may raise luteinizing hormone (LH). Fadogia Agrestis is thought to act as an LH analog, stimulating Leydig cells in the testes to produce more testosterone. Used together they target two different points of the HPG axis.

How it works in more detail

Tongkat Ali (Eurycoma longifolia) is thought to exert its effects through several mechanisms. It may stimulate the release of luteinizing hormone (LH), which in turn signals the Leydig cells in the testes to produce testosterone. Some research suggests it might also reduce sex hormone-binding globulin (SHBG), thereby increasing free testosterone levels. Additionally, Tongkat Ali has been shown to reduce cortisol, a stress hormone, which can indirectly support testosterone balance [6]. The specific mechanisms of Fadogia Agrestis in humans are not well-established, but preclinical animal studies suggest it may increase testicular cholesterol, a precursor to steroid hormones, and enhance testicular activity [8].

How to use

Always consult a qualified clinician.

Editorial guidance

Suggested dosage
Common protocol: Tongkat Ali 200–400 mg/day (standardized extract) + Fadogia Agrestis 400–600 mg/day, both taken in the morning. Cycle 3 weeks on, 1 week off when stacked together. Start at the low end of each dose and adjust based on response and follow-up blood work.
Research dosage range
Tongkat Ali: 200–600 mg/day in human trials. Fadogia Agrestis: 400–1200 mg/day reported anecdotally; no established human dose-range from clinical trials.
Typical onset
Subjective effects (libido, mood, drive) often reported within 2–4 weeks; hormonal changes typically assessed via blood work after 8–12 weeks.
Typical forms
capsule, powder, standardized extract
Quality markers
For Tongkat Ali, look for standardized extracts, often specified by the percentage of eurycomanone or other active compounds. Reputable manufacturers should provide third-party testing for purity and potency. For Fadogia Agrestis, due to limited research, quality markers are less defined, but sourci
Medication interactions
  • testosterone replacement therapy (TRT)
  • aromatase inhibitors
  • 5-alpha reductase inhibitors (finasteride, dutasteride)
  • SSRIs
  • anticoagulants
  • diabetes medications (possible additive effects)
Avoid if
  • hormone-sensitive cancers (prostate, breast)
  • active or history of testicular or liver disease
  • men with already-elevated hematocrit or testosterone
  • adolescents
  • women who are or may become pregnant
Pregnancy / lactation
Do not use during pregnancy or breastfeeding. Not appropriate for women trying to conceive.

Community tips

No community tips yet — be the first to share what worked for you.

Suggested dosage

Common protocol: Tongkat Ali 200–400 mg/day (standardized extract) + Fadogia Agrestis 400–600 mg/day, both taken in the morning. Cycle 3 weeks on, 1 week off when stacked together. Start at the low end of each dose and adjust based on response and follow-up blood work.

General guidance — discuss specifics with a clinician.

Active medicinal compounds

Tongkat Ali: quassinoids (eurycomanone), eurypeptides, glycosaponins. Fadogia Agrestis: alkaloids, saponins, flavonoids (specific actives not well characterized).

Traditional use

Tongkat Ali has a long history in Southeast Asian traditional medicine (Malaysia, Indonesia) as a tonic for vitality, libido, and "male strength." Fadogia Agrestis has been used in parts of West Africa as a traditional aphrodisiac.

Safety

Safety warnings

Fadogia Agrestis lacks robust human safety data. Rodent studies have raised concerns about possible testicular and organ toxicity at high doses. Cycle the stack (commonly 3 weeks on / 1 week off) and obtain baseline plus follow-up labs (total/free testosterone, LH, FSH, estradiol, liver enzymes, lipid panel, hematocrit). Discontinue if liver enzymes rise, hematocrit climbs, or blood pressure increases.

Avoid if

  • hormone-sensitive cancers (prostate, breast)
  • active or history of testicular or liver disease
  • men with already-elevated hematocrit or testosterone
  • adolescents
  • women who are or may become pregnant

Medication interactions

  • testosterone replacement therapy (TRT)
  • aromatase inhibitors
  • 5-alpha reductase inhibitors (finasteride, dutasteride)
  • SSRIs
  • anticoagulants
  • diabetes medications (possible additive effects)

Reported side effects

  • insomnia or restlessness if taken late in the day
  • irritability or aggression
  • increased libido
  • possible elevations in hematocrit or blood pressure
  • potential liver enzyme elevations (Fadogia)

Pregnancy & lactation

Do not use during pregnancy or breastfeeding. Not appropriate for women trying to conceive.

General guidance — discuss specifics with a clinician.

Evidence ecosystem

Scientific literature, clinical guidance, government sources, ongoing research, traditional use, and lived experience — grouped by source type and quality.

Overall grade (A)

Tongkat Ali has a modest but reasonable body of human RCTs supporting effects on free testosterone, SHBG, and stress markers (Grade B individually). Fadogia Agrestis has essentially no human clinical trials — evidence is limited to rodent studies and anecdote. The combined stack itself has not been formally studied in humans, so the combined evidence grade is downgraded to C.

Filter by source type

Systematic Reviews(4)

Structured reviews of the full body of evidence (incl. Cochrane).

Very High Quality

  • Do "testosterone boosters" really increase serum total testosterone? A systematic review

    Kim MJ, Lee JH, et al. · Int J Impot Res · 2024

    Among reviewed ingredients, evidence for a true increase in total testosterone was limited; Eurycoma longifolia showed the most consistent positive signal across trials.

    Systematic ReviewPubMedHigh Quality

  • A systematic review and evidence-based analysis of ingredients in popular male testosterone and erectile dysfunction supplements

    Clemesha CG, Thaker H, Samplaski MK · Int J Impot Res · 2020

    Tongkat Ali (Eurycoma longifolia) was among a small group of ingredients with at least some supportive human data for raising serum testosterone; many other ingredients lacked clinical support.

    Systematic ReviewPubMedHigh Quality

  • An Analysis of Popular Online Erectile Dysfunction Supplements.

    Balasubramanian A, Thirumavalavan N, Srivatsav A, Yu J, Hotaling JM, Lipshultz LI · The journal of sexual medicine · 2019

    Erectile dysfunction supplements (ED-Ss) are featured on online marketplaces like Amazon.com, with dedicated pages and claims that they naturally treat ED. However, their efficacy and safety are largely unknown, limiting the ability to counsel patients regarding their use. To evaluate the highest rated and most frequently reviewed ED-Ss on Amazon.com to facilitate patient counseling regarding marketing myths, ingredient profiles, and evidence for product efficacy and safety. The Amazon marketplace was queried using the key term "erectile dysfunction" with default search settings and ranking items based on relevance. The top 6 ED-S products identified on September 29, 2018, were reviewed based on price, ratings, reviews, manufacturer, and ingredients. Consumer reviews were categorized using subtopics within the International Index of Erectile Function (IIEF) questionnaire to better understand ED-S efficacy and then reanalyzed following filtration of untrustworthy comments using Review

    Systematic ReviewPubMedVery High Quality

Randomized Human Trials(6)

Controlled human studies with random assignment.

High Quality

Animal Studies(1)

Preclinical animal research — not a substitute for human evidence.

Low Quality

Limitations: Key limitations include the relatively small sample sizes in some human studies on Tongkat Ali [2, 3, 5, 7]. While some studies are RCTs, more large-scale, long-term trials are needed. For Fadogia Agrestis, the evidence is almost exclusively preclinical (animal studies), which may not translate to human effects [8]. Systematic reviews indicate that many "testosterone boosters" lack strong evidence [1, 4]. There is a significant lack of research on the combined use of Tongkat Ali and Fadogia Agrestis.

This page is educational. Statements use phrases like "may support" and "has been studied for"because no remedy here is approved to cure, treat, or reverse any condition. Discussion happens on the ailment pages — community statistics here are derived from those reports. Always consult a qualified clinician.

Tried Tongkat Ali + Fadogia Agrestis Stack?

Help others see what actually works.