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Iberogast

Relieving symptoms of functional dyspepsia and supporting digestive motility.

Evidence · Grade B
Human trial evidenceTraditional use

Iberogast is a nine-herb formulation used for gastrointestinal symptoms. It is cited in clinical guidelines for its potential role in managing functional dyspepsia and various symptoms of gastric motility disorders.

Last reviewed June 13, 2026 · AI-assisted, human-reviewed
Iberogast, also known as STW 5, is a commercial herbal formulation composed of nine different plant extracts. It has been used historically for a range of gastrointestinal disorders, including functional dyspepsia and symptoms associated with impaired gastric motility. Clinical reviews and consensus papers, such as the 2017 Mexican consensus on dyspepsia, have evaluated its role in managing upper gastrointestinal complaints. The formulation is often examined for its potential to modulate smooth muscle activity in the stomach and intestines, which may influence conditions where gastric emptying is delayed or where acid-related symptoms persist.

Quick answer

What it is: Iberogast, also known as STW 5, is a commercial herbal formulation composed of nine different plant extracts.

May support:Gastroparesis, Acid Reflux (GERD), GERD

Evidence:Evidence · Grade B

Evidence Summary

Evidence · Grade B

Expert consensus guidelines, including the 2017 update by the Asociación Mexicana de Gastroenterología, have recognized the role of herbal formulations like Iberogast in the systematic management of dyspepsia based on a review of clinical literature spanning 2007 to 2016.

Last reviewed · Jun 2026

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Why It Works

Iberogast is thought to exert a dual effect on gastrointestinal muscles: relaxing the upper stomach (fundus) to accommodate food while stimulating the lower stomach (antrum) to assist emptying.

How it works in more detail

The nine herbal components of Iberogast are thought to act synergistically. For instance, some extracts (e.g., Iberis amara, peppermint) may influence gastric emptying and intestinal transit. Others (e.g., chamomile, licorice) may exhibit anti-inflammatory and antispasmodic effects, potentially reducing pain and discomfort. Specific compounds within these extracts may interact with various receptors and pathways in the gut, such as serotonin receptors and calcium channels, to modulate smooth muscle activity and nerve signaling. The combined action aims to normalize gastrointestinal function and alleviate symptoms.

How to use

Always consult a qualified clinician.

Editorial guidance

Suggested dosage
Usually 20 drops (1 mL) three times a day, taken before or with meals, in a small amount of liquid. Dosage may vary based on specific product formulations and healthcare professional recommendations.
Research dosage range
Research studies typically use the recommended dosage of 20 drops (1 ml) three times daily.
Typical onset
Some individuals may experience symptom relief within a few days, while others may require several weeks of consistent use to observe significant improvements.
Typical forms
liquid drops
Quality markers
Look for products from reputable manufacturers that adhere to good manufacturing practices (GMP). Ensure the product lists all nine herbal ingredients and their standardized extracts if applicable. Check for expiration dates and proper storage instructions.
Avoid if
  • known allergy to any of the ingredients
  • pre-existing liver disease (consult doctor)
  • pregnancy (consult doctor)
  • breastfeeding (consult doctor)
  • children under 3 years old (consult doctor)

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Suggested dosage

Usually 20 drops (1 mL) three times a day, taken before or with meals, in a small amount of liquid. Dosage may vary based on specific product formulations and healthcare professional recommendations.

General guidance — discuss specifics with a clinician.

Active medicinal compounds

Key active compounds are derived from the nine plant extracts: Iberis amara, Angelica archangelica, Matricaria recutita (chamomile), Carum carvi (caraway), Silybum marianum (milk thistle), Melissa officinalis (lemon balm), Mentha piperita (peppermint), Chelidonium majus (celandine), and Glycyrrhiza glabra (licorice).

Traditional use

The individual herbal components of Iberogast have a long history of traditional use in various cultures for digestive complaints. For example, peppermint has been used for indigestion and colic, chamomile for its calming and anti-inflammatory properties, and licorice for stomach discomfort. The specific combination in Iberogast is a modern formulation based on these traditional uses.

Safety

Safety warnings

Individuals should consult a healthcare provider before use, particularly if they have liver disease, as rare instances of hepatotoxicity have been reported with herbal supplements. Usage should be discontinued if jaundice or dark urine occurs.

Avoid if

  • known allergy to any of the ingredients
  • pre-existing liver disease (consult doctor)
  • pregnancy (consult doctor)
  • breastfeeding (consult doctor)
  • children under 3 years old (consult doctor)

Reported side effects

  • mild gastrointestinal upset
  • allergic reactions (skin rash, itching)

General guidance — discuss specifics with a clinician.

Evidence ecosystem

Scientific literature, clinical guidance, government sources, ongoing research, traditional use, and lived experience — grouped by source type and quality.

Overall grade (B)

Expert consensus guidelines, including the 2017 update by the Asociación Mexicana de Gastroenterología, have recognized the role of herbal formulations like Iberogast in the systematic management of dyspepsia based on a review of clinical literature spanning 2007 to 2016.

Clinical Guidelines(1)

Recommendations from medical societies (NICE, AHA, ADA, ACG, Endocrine Society…).

High Quality

  • Mexican consensus on dyspepsia.

    Carmona-Sánchez R, Gómez-Escudero O, Zavala-Solares M, Bielsa-Fernández MV, Coss-Adame E, Hernández-Guerrero AI · Revista de gastroenterologia de Mexico · 2017

    Since the publication of the 2007 dyspepsia guidelines of the Asociación Mexicana de Gastroenterología, there have been significant advances in the knowledge of this disease. A systematic search of the literature in PubMed (01/2007 to 06/2016) was carried out to review and update the 2007 guidelines and to provide new evidence-based recommendations. All high-quality articles in Spanish and English were included. Statements were formulated and voted upon using the Delphi method. The level of evidence and strength of recommendation of each statement were established according to the GRADE system. Thirty-one statements were formulated, voted upon, and graded. New definition, classification, epidemiology, and pathophysiology data were provided and include the following information: Endoscopy should be carried out in cases of uninvestigated dyspepsia when there are alarm symptoms or no response to treatment. Gastric and duodenal biopsies can confirm Helicobacter pylori infection a

    Clinical GuidelinePubMed (Practice Guideline)Very High Quality

Limitations: While cited in regional guidelines, more large-scale, international multi-center trials are often cited as necessary to further confirm efficacy across diverse populations and specific subtypes of GERD.

This page is educational. Statements use phrases like "may support" and "has been studied for"because no remedy here is approved to cure, treat, or reverse any condition. Discussion happens on the ailment pages — community statistics here are derived from those reports. Always consult a qualified clinician.

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