Gastroparesis is a condition where the stomach empties food into the small intestine too slowly, often due to nerve damage affecting stomach muscle contractions.
Ranked by community outcomes, then evidence grade, Health Voice mentions, and recency.
Why it may help Gastroparesis: Stimulates gastric emptying
Elimination diet restricting fermentable carbohydrates (FODMAPs) shown to reduce IBS symptoms in most patients.
Iberogast is a nine-herb formulation used for gastrointestinal symptoms. It is cited in clinical guidelines for its potential role in managing functional dyspepsia and various symptoms of gastric motility disorders.
Deglycyrrhizinated licorice for ulcers and GERD without BP effect.
Why it may help Gastroparesis: Digestive enzymes may help manage gastroparesis by breaking down food more efficiently, thereby reducing the burden on a slow-emptying stomach and improving nutrient absorption.
Why it may help Gastroparesis: Artichoke extract may alleviate gastroparesis symptoms by stimulating bile flow and promoting gastrointestinal motility, which can help improve the rate of gastric emptying.
Why it may help Gastroparesis: Fennel may help alleviate gastroparesis symptoms by acting as a carminative, reducing gas and bloating, and potentially stimulating smooth muscle contractions to improve gastric motility.
Why it may help Gastroparesis: Repletes deficiencies from poor intake
Demulcent herb (Ulmus rubra) traditionally used to soothe GI mucosa.
Mucilaginous herb soothing GI and respiratory mucosa.
Why it may help Gastroparesis: Eases muscle and nerve function
Why it may help Gastroparesis: Calms upper GI symptoms
Why it may help Gastroparesis: Eases nausea and discomfort
Why it may help Gastroparesis: Helps diabetic gastroparesis
Why it may help Gastroparesis: Supports overall gut function
Active B12 form essential for nerve function and red blood cell production.
Community outcomes
Self-reported by community members · not medical advice.
Self-reported community outcomes. Not medical advice. Requires at least three reports per remedy to surface.
Community outcome data is still being collected for this ailment.
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Community Discussions
How global health authorities view Gastroparesis.
Major health organizations like the Mayo Clinic and NIH acknowledge gastroparesis as a challenging condition, primarily managed through dietary changes and conventional medications. While they emphasize the importance of lifestyle modifications, there is generally limited endorsement of specific natural remedies for direct treatment of gastroparesis due to a lack of robust clinical trials. They typically advise caution with supplements and herbs, recommending discussion with a healthcare provider due to potential interactions with medications or underlying conditions. The focus remains on managing symptoms and addressing underlying causes, such as diabetes.
Indexed studies for Gastroparesis, grouped by source type and quality.
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Pooled analyses across multiple human trials.
Eckhardt D, Elshafei M, Fechner K, Diener MK, Hüttner FJ · The British journal of surgery · 2025
Gastroparesis is a chronic gastric motility disorder characterized by delayed gastric emptying in the absence of mechanical obstruction. Patients often experience nausea, vomiting, bloating, and early satiety. Several treatment options exist, including dietary changes, pharmacological agents, botulinum toxin injection, gastric electrical stimulation (GES), pyloroplasty, and gastric per-oral endoscopic myotomy (G-POEM). However, comparative effectiveness data are limited. A systematic review and network meta-analysis (NMA) was conducted to evaluate the relative effectiveness of interventions for gastroparesis. A literature search in PubMed, Google Scholar, and Cochrane CENTRAL (1982 to 31 May 2024) identified studies involving adults with scintigraphically confirmed gastroparesis and symptom assessment using the Gastroparesis Cardinal Symptom Index (GCSI) or Total Symptom Score (TSS). A DerSimonian-Laird random-effects meta-analysis and NMA with standardized mean differences were perfo
Varghese C, Lim A, Daker C, Sebaratnam G, Gharibans AA, Andrews CN · The American journal of gastroenterology · 2024
Gastroparesis is a debilitating gastroduodenal disorder for which gastric peroral endoscopic myotomy (GPOEM) has emerged as an efficacious treatment option. However, response to GPOEM varies between 50% and 80%, such that preoperative predictors of treatment success are needed to guide patient selection. We performed a systematic review to identify predictors of clinical and functional response to GPOEM among adult patients with gastroparesis (PROSPERO: CRD42023457359). MEDLINE, Embase, and CENTRAL databases were searched systematically for studies reporting outcomes after GPOEM in September 2023. A narrative synthesis of predictive factors on univariable and multivariable analysis was performed with consideration of response rates through meta-analysis and evaluation of discrimination if prognostic models were developed. Risk Of Bias In Non-randomized Studies - of Exposures (ROBINS-E) was used for risk of bias assessment. Of 1899 articles reviewed, 30 were included. The GPOEM respon
An overview of systematic reviews of acupuncture for diabetic gastroparesis.
Li T, Yu M, Han L, Feng B, Sun F · Frontiers in medicine · 2023
To date, several systematic reviews and/or meta-analyses (SRs/MAs) on the topic of acupuncture as a treatment for diabetic gastroparesis (DGP) have been published. However, whether acupuncture is an effective and safe treatment for DGP remains controversial. In this study, we aimed to determine whether the methodology and results of previously published SRs/MAs of acupuncture as a treatment for DGP were of sufficient quality to be considered reliable. We extensively searched seven databases, including PubMed, EMBASE, Cochrane Library, Web of Science, China National Knowledge, Wan Fang, and Chongqing VIP, for SRs/MAs published before or on September 16, 2022. The SRs/MAs that met the inclusion criteria were evaluated for the quality of the methodology and results using the Assessing the Methodological Quality of Systematic Reviews Two (AMSTAR-2) and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tools. A re-meta-analysis of primary outcome indicators was al
Structured reviews of the full body of evidence (incl. Cochrane).
Efficacy of vagus nerve stimulation in gastrointestinal disorders: a systematic review.
Veldman F, Hawinkels K, Keszthelyi D · Gastroenterology report · 2025 · n=644
Dysfunction of the vagus nerve has been suggested as a contributing factor in various gastrointestinal disorders, prompting interest in vagus nerve stimulation (VNS) as a non-pharmacological therapy. We performed a systematic review to determine the efficacy of invasive and non-invasive VNS in gastrointestinal disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), functional dyspepsia (FD), functional constipation, gastroesophageal reflux disease, and gastroparesis. We applied a systematic search of the literature in the PubMed, Embase, Web of Science, and Cochrane Library databases in order to identify studies comparing VNS with an adequate control condition (sham stimulation) in patients with gastrointestinal disorders. The primary outcome was adequate symptom relief. Methodological quality was evaluated using the revised Cochrane risk-of-bias tool. Meta-analyses were not performed due to study heterogeneity. Seven randomized controlled trials investig
Bachmann KF, Jenkins B, Asrani V, Bear DE, Bolondi G, Boraso S · Critical care (London, England) · 2024 · n=285
Gastrointestinal (GI) dysfunction is common in critically ill patients and associated with poor outcomes. There is a lack of standardised methods for daily monitoring of GI function. COSMOGI aimed to develop a Core Outcome Set (COS) for daily monitoring of GI function to improve consistency and comparability in future studies in critically ill patients. A modified Delphi consensus process engaging healthcare providers, clinical researchers, and patient representatives was performed. A systematic review identified existing parameters to monitor GI function, informing the development of potential outcomes. In Stage 1, participants rated outcomes (i.e., variables used for daily monitoring). In Stage 2, they refined and agreed on the definitions for the selected outcomes. The COS was ratified through consensus meetings. 368 individuals registered for the Delphi process. 285 participants (77.4%) completed Stage 1, and 181 participants (63.5%) completed Stage 2. From 77 potential outcomes,
Gastroparesis: an evidence-based review for the bariatric and foregut surgeon.
Bardaro SJ, Guerron AD, Romanelli J, Soriano I, King K, Gibbs KE · Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2023
Gastroparesis is a gastric motility disorder characterized by delayed gastric emptying. It is a rare disease and difficult to treat effectively; management is a dilemma for gastroenterologists and surgeons alike. We conducted a systematic review of the literature to evaluate current diagnostic tools as well as treatment options. We describe key elements in the pathophysiology of the disease, in addition to current evidence on treatment alternatives, including nutritional considerations, medical and surgical options, and related outcomes.
Controlled human studies with random assignment.
Clinical Characteristics of Autoimmune Gastroparesis and Response to Immunomodulation.
Simons M, Loesch J, Hamza E, Brown JT, Lembo A, Cline M · Journal of clinical gastroenterology · 2025
Autoimmune factors may be involved in the development of gastroparesis, a subtype known as autoimmune gastrointestinal dysmotility (AGID). Small open label studies in AGID have demonstrated intravenous immunoglobulin (IVIG) therapy may lead to improvement in symptoms and gastric emptying. We aimed to evaluate the effects of IVIG therapy on symptom severity in patients with gastroparesis. We conducted a retrospective case series involving patients with AGID through medical chart review. All patients had evidence of delayed gastric emptying through gastric scintigraphy (GES) and had evidence of autoimmune dysfunction through seropositive antibody bloodwork, including glutamic acid decarboxylase (GAD), neuronal voltage-gated calcium channel, acetylcholine receptor, and neuronal voltage gated potassium channel autoantibodies. All patients received at least 12 weeks of IVIG therapy. Gastroparesis Cardinal Symptom Index (GCSI) scores were collected pre-IVIG and post-IVIG treatment. We anal
Zhu Y, Sarosiek I, Sun Y, Yin J, Abell T, Nojkov B · Neurogastroenterology and motility · 2025
Gastroparesis is common in patients with diabetes. However, treatment options for diabetic gastroparesis are limited. Transcutaneous electrical acustimulation (TEA), a noninvasive method of delivering electrical stimulation via surface electrodes placed at certain acupuncture points that are in the vicinity of peripheral nerves, has been reported to exert therapeutic effects in patients with gastroesophageal reflux, functional dyspepsia, and constipation. The aim of this study was to explore the therapeutic potential of TEA for diabetic gastroparesis. Eighteen patients with diabetes were enrolled in a single-center, placebo-controlled, randomized and crossover trial with TEA and sham-TEA. TEA was performed twice daily after lunch and dinner via acupoints, ST36 (below the kneecap in the vicinity of the peroneal, sciatic, and tibial nerves) and PC6 (wrist above the median nerve) for 4 weeks. A set of parameters previously reported to improve gastrointestinal motility was used for
Zheng T, BouSaba J, Taylor A, Dilmaghani S, Busciglio I, Carlson P · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023 · n=44
Cannabis (delta-9-tetrahydrocannabinol), a nonselective cannabinoid-receptor agonist, relieves nausea and pain. Cannabidiol (CBD), a cannabinoid receptor 2 inverse agonist with central effects, also reduces gut sensation and inflammation. We compared the effects of 4 weeks of treatment with pharmaceutical CBD vs placebo in patients with idiopathic or diabetic (diabetes mellitus) gastroparesis. We performed a randomized, double-blinded, placebo-controlled study of CBD twice daily (Epidiolex escalated to 20 mg/kg/d; Jazz Pharmaceuticals, Dublin, Ireland) in patients with nonsurgical gastroparesis with delayed gastric emptying of solids (GES). Symptoms were assessed by the Gastroparesis Cardinal Symptom Index Daily Diary. After 4 weeks of treatment, we measured GES, gastric volumes, and Ensure (Abbott Laboratories, Abbott Park, IL) satiation test (1 kcal/mL, 30 mL/min) to assess volume to comfortable fullness and maximum tolerance. Patients underwent specific FAAH and CNR1 genotyping. St
Cohort, case-control, and cross-sectional human studies.
Lee A · Drugs · 2026
Tradipitant (NEREUS™) is a small molecule neurokinin-1 (NK-1) receptor antagonist being developed by Vanda Pharmaceuticals. NK-1 receptor activation and substance P release in the central nervous system leads to nausea and vomiting symptoms associated with motion sickness. Tradipitant received its first approval in the USA in December 2025 for the prevention of vomiting induced by motion in adults, and is also being developed for the treatment of gastroparesis and prevention of vomiting induced by GLP-1 receptor agonists. In phase III trials, tradipitant reduced the incidence of vomiting associated with motion sickness. This article summarizes the milestones in the development of tradipitant leading to this first approval for the prevention of vomiting induced by motion in adults.
Hanna-Jairala I, Tack J, Drossman DA · Neurogastroenterology and motility · 2026
Functional dyspepsia (FD) is a disorder of gut-brain interaction (DGBI), while gastroparesis (GP) is a motility disorder with overlapping upper gastrointestinal symptoms, including epigastric pain, postprandial fullness, early satiation, nausea, and vomiting, although their relative prevalence differs between conditions. First-line therapies, such as proton pump inhibitors and Helicobacter pylori eradication, often provide limited relief, prompting interest in alternative, mechanism-based treatments. To review the literature on the use of predominantly central and predominantly peripheral neuromodulators in FD and GP and to develop a symptom-directed therapeutic framework. We conducted a comprehensive review of the literature, synthesizing data from randomized controlled trials, observational studies, and clinical guidelines. Pharmacological profiles, pathophysiological targets, and safety considerations were evaluated. Predominantly central neuromodulators, particularly tricyclic a
Schol J, Huang IH, Carbone F, Fernandez LMB, Gourcerol G, Ho V · The lancet. Gastroenterology & hepatology · 2025
To establish a consensus on the definition and management of idiopathic gastroparesis, international experts (selected by neurogastroenterology and motility societies and initiated by the Rome Foundation) devised 144 statements using the Delphi method, with at least 80% agreement required. This consensus defined idiopathic gastroparesis as the presence of symptoms associated with delayed gastric emptying in the absence of mechanical obstruction. Nausea and vomiting were identified as cardinal symptoms. Frequently co-existing symptoms are early satiation and postprandial fullness. Diagnosis requires the presence of these symptoms alongside delayed gastric emptying, measured by a 4 h scintigraphy or gastric emptying breath test of a mixed composition meal in the absence of mechanical obstruction. Therapeutic options with proven efficacy were sparse. Dietary adjustments, nutritional support (per guidelines from the European Society for Clinical Nutrition and Metabolism for substantial wei
Registered ongoing or completed trials (ClinicalTrials.gov).
n=12 · NCT00492622 · COMPLETED · COMPLETED
The purpose of this study is to compare the blood drug levels of two prescribed medications, immediate-release omeprazole 40 mg powder and delayed-release omeprazole 40 mg capsule to determine which drug is better absorbed in patients with a slow stomach emptying (gastroparesis). Delayed-release omeprazole has a protective coating to prevent the drug omeprazole from being neutralized by stomach acid. Immediate-release omeprazole has sodium bicarbonate (antacid) which neutralizes the stomach acid, eliminating the need for a protective coating. Immediate-release omeprazole suspension may have a more rapid pharmacokinetic profile and greater overall drug absorption in gastroparesis.
n=12 · NCT04762719 · COMPLETED · COMPLETED
Macrophage-driven immune dysregulation has been shown to be involved in pathophysiology of diabetic gastroparesis. Currently, there are no non-invasive ways to study macrophage activation in humans. The researchers are trying to determine the utility of 11C-ER176 based PET-CT scanning to determine pro-inflammatory macrophage activation in gastric wall of patients with diabetic gastroparesis.
Telehealth Administration of 13C-Spirulina Gastric Emptying Breath Test (13C-GEBT) Usability Study
n=36 · NCT04684992 · COMPLETED · COMPLETED
The purpose of this study is to establish the usability of a telehealth platform for the administration of GEBT.
Curated cross-source summaries (TRIP Database and similar).
NICE
NICE provides access to clinical guidelines, technology appraisals, and other guidance related to gastroparesis. While there isn't a dedicated guideline specifically titled 'Gastroparesis' from NICE, relevant information can be found through their search portal.
Conventional medical care for gastroparesis typically involves medications to stimulate stomach emptying (prokinetics) and antiemetics to control nausea and vomiting. Dietary counseling is a cornerstone of treatment. In severe cases, nutritional support via feeding tubes or gastric electrical stimulation may be considered. Regular monitoring and management of underlying conditions, especially diab
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This information is for educational purposes only and does not constitute medical advice. Gastroparesis is a serious condition requiring professional medical diagnosis and management. Always consult with a qualified healthcare provider before making any decisions about your health or treatment plan.
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