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Autism Spectrum

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Last reviewed June 12, 2026 · AI-assisted, human-reviewed

Overview

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by differences in social communication and interaction, and restricted, repetitive patterns of behavior, interests, or activities.

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition that typically appears in early childhood. It is called a "spectrum" disorder because the symptoms and their severity can vary widely among individuals. While some individuals with ASD may have significant challenges requiring substantial support, others may have milder symptoms and require less support. The core features of ASD involve persistent deficits in social communication and social interaction across multiple contexts, and restricted, repetitive patterns of behavior, interests, or activities. The exact causes of ASD are not fully understood, but research suggests a combination of genetic and environmental factors. There is no single known cause, and it is believed that multiple factors contribute to its development. Early diagnosis and intervention are often associated with improved outcomes, as interventions can help individuals develop social, communication, and behavioral skills. Management often involves a multidisciplinary approach tailored to the individual's specific needs. It is important to note that ASD is a lifelong condition, and interventions aim to support individuals in developing their full potential and improving their quality of life. There is no "cure" for autism, but various therapies and supports can help individuals with ASD learn new skills and overcome challenges.
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When to seek urgent medical care

  • No babbling or gesturing by 12 months
  • No single words by 16 months
  • No two-word phrases by 24 months
  • Loss of previously acquired speech or social skills
  • Lack of eye contact by 6 months
  • Lack of smiling or joyful expressions by 6 months
  • Lack of response to name by 12 months
  • Lack of pointing or showing objects by 12 months

Common symptoms

  • Difficulty with social interaction
  • Repetitive behaviors
  • Challenges with verbal communication
  • Limited eye contact
  • Strong adherence to routines
  • Intense focus on specific interests
  • Unusual reactions to sensory input
  • Difficulty understanding nonverbal cues

Possible contributors

  • Genetic factors
  • Environmental factors (e.g., prenatal exposure)
  • Brain structure differences
  • Neurotransmitter imbalances
  • Immune system dysregulation
  • Maternal health during pregnancy
  • Advanced parental age

Labs to discuss with your clinician

  • Vitamin D levels
  • Omega-3 index
  • Comprehensive metabolic panel
  • Thyroid function tests
  • Genetic testing (if indicated)
  • Heavy metal screening (if clinically suspected)

All Remedies

Ranked by community outcomes, then evidence grade, Health Voice mentions, and recency.

Remedies

#1Vitamin D3Evidence · Grade ASafety: caution60% helpful · 5 reportsView remedy

Why it may help Autism Spectrum: Vitamin D3 is studied for its potential role in modulating immune responses, specifically Th1/Th17, which may be relevant in some presentations of autism spectrum disorder (ASD). It also appears to support myelin repair signaling and calcium homeostasis, processes that have been investigated in the context of neurological development. These biological actions suggest a theoretical basis for its exploration in ASD.

Typical dose
1000-5000 IU daily (to achieve optimal levels)
Mechanism
Plays a role in brain development and immune function, which may be relevant in ASD.
Notes
Monitor blood levels to avoid toxicity.
Evidence
limited

Individuals with ASD who may have altered calcium metabolism or kidney function should be monitored when considering vitamin D3 supplementation. Hypercalcemia is a potential concern with high doses, and symptoms might be communicated differently by individuals with ASD. Interactions with certain medications used in ASD management should also be considered.

#2Low-FODMAP DietEvidence · Grade ASafety: watchView remedy

Elimination diet restricting fermentable carbohydrates (FODMAPs) shown to reduce IBS symptoms in most patients.

#3MelatoninEvidence · Grade BSafety: watchView remedy

Why it may help Autism Spectrum: Melatonin can improve sleep onset and duration in individuals with Autism Spectrum Disorder by regulating the sleep-wake cycle, which is often disrupted due to altered melatonin production or sensitivity in this population.

Typical dose
0.5-5 mg 30-60 minutes before bedtime
Mechanism
May help regulate sleep-wake cycles, addressing common sleep disturbances in ASD.
Notes
Start with the lowest effective dose; consult a healthcare provider.
Evidence
moderate

Emerging Research

#1Omega-3 Fish OilEvidence · Grade CSafety: caution80% helpful · 5 reportsView remedy

Why it may help Autism Spectrum: Omega-3 fatty acids, specifically EPA and DHA, are studied for their potential roles in neurodevelopment and inflammation. DHA is a key structural component of neuronal membranes and myelin, which may support brain function. EPA and DHA are also precursors to resolvins and protectins, compounds that may play a role in resolving inflammation, a process hypothesized to be dysregulated in some individuals with autism spectrum disorder.

As with any supplement, individuals on concomitant medications, especially those affecting blood clotting, should exercise caution due to the potential for increased bleeding risk at high doses. Always choose third-party-tested products to ensure they are free from contaminants, which is particularly important for children.

#2ProbioticsEvidence · Grade DSafety: caution60% helpful · 5 reportsView remedy

Why it may help Autism Spectrum: Probiotics may influence the gut-brain axis, which is an area of interest in autism spectrum disorder (ASD) research. They are studied for their potential to modulate gut microbiota composition, short-chain fatty acid production, and intestinal barrier function. These actions may indirectly affect neurological processes and behavioral outcomes observed in some individuals with ASD.

Typical dose
Various strains and CFUs, as directed
Mechanism
May support gut health and the gut-brain axis, potentially influencing mood and behavior.
Notes
Specific strains may be more beneficial; consult a healthcare provider.
Evidence
limited

Generally, probiotics are considered safe; however, individuals with ASD who have compromised immune systems or complex medical conditions should use probiotics with caution and under medical supervision. There is a rare risk of bacteremia in severely immunocompromised individuals.

#3SaffronEvidence · Grade DSafety: caution60% helpful · 5 reportsView remedy

Why it may help Autism Spectrum: Saffron, primarily through its constituents crocin and safranal, has been studied for its potential to modulate neurotransmitter systems, including serotonin, dopamine, and NMDA pathways, which are thought to be implicated in some aspects of Autism Spectrum Disorder (ASD). These modulatory effects may contribute to saffron's observed impact on mood, anxiety, and cognitive functions. It appears to offer neuroprotective and anti-inflammatory properties, which might be beneficial given some proposed theories of ASD etiology.

Saffron doses exceeding 1.5 grams per day are generally considered toxic and should be avoided. Due to its uterotonic properties, saffron is contraindicated during pregnancy. Individuals with pre-existing medical conditions or those taking other medications should consult a healthcare professional before considering saffron supplementation.

#4Lion's Mane MushroomEvidence · Grade DSafety: caution60% helpful · 5 reportsView remedy

Why it may help Autism Spectrum: Lion's Mane mushroom contains compounds like hericenones and erinacines, which appear to stimulate nerve growth factor (NGF) synthesis. In individuals with Autism Spectrum Disorder (ASD), there is interest in agents that may support neurological development and function. Increased NGF levels could potentially contribute to neurogenesis and myelin formation, which are areas of ongoing research in ASD.

Individuals with ASD, particularly children, may have unique sensitivities or co-occurring conditions, making it crucial to discuss any supplementation with a healthcare professional. Information regarding drug interactions specific to ASD medications and Lion's Mane is limited. Discontinue use if any adverse reactions, such as skin rash or breathing difficulties, occur.

#5Broccoli Sprouts (Sulforaphane)Evidence · Grade DSafety: caution40% helpful · 5 reportsView remedy

Why it may help Autism Spectrum: Sulforaphane, found in broccoli sprouts, has been studied for its potential modulatory effects on various biological pathways relevant to autism spectrum disorder (ASD). It appears to activate the Nrf2 antioxidant pathway, which may help to reduce oxidative stress and inflammation, processes that are sometimes implicated in ASD. Additionally, sulforaphane may support detoxification processes and cellular resilience.

While generally considered safe, high doses of raw broccoli sprouts may cause gastrointestinal discomfort. Individuals with ASD who have existing thyroid conditions should be aware of potential goitrogenic effects of very large amounts of raw cruciferous vegetables. Always consult a healthcare professional regarding potential interactions with medications or existing health conditions relevant to ASD.

#6ExerciseEvidence · Grade DSafety: watchView remedy

Aerobic and resistance exercise have RCT-grade evidence for depression, comparable to SSRIs in mild-moderate cases.

#7Omega-3 Fatty AcidsEvidence · Grade DSafety: watchView remedy

Why it may help Autism Spectrum: Omega-3 fatty acids can modulate neuroinflammation and support neuronal membrane fluidity, potentially improving communication pathways and mitigating some behavioral challenges in autism spectrum disorder.

Typical dose
500-1500 mg EPA+DHA daily
Mechanism
May support brain function and reduce inflammation, potentially impacting behavioral symptoms.
Notes
Consult a healthcare provider, especially if on blood thinners.
Evidence
moderate
#8N-Acetyl Cysteine (NAC)Evidence · Grade DSafety: watchView remedy

Why it may help Autism Spectrum: N-Acetyl Cysteine (NAC) may improve social responsiveness and reduce repetitive behaviors in Autism Spectrum Disorder by modulating glutamatergic neurotransmission and supporting antioxidant defenses, which are often dysregulated in this condition.

Typical dose
500-1800 mg daily
Mechanism
Antioxidant properties and modulation of glutamate, potentially impacting repetitive behaviors and irritability.
Notes
Consult a healthcare provider before use.
Evidence
limited
#9AshwagandhaEvidence · Grade DSafety: watchView remedy

An adaptogenic herb that has been studied for stress, thyroid function, and energy.

#10Lemon BalmEvidence · Grade DSafety: watchView remedy

A calming mint-family herb that has been studied for hyperthyroidism, anxiety, and sleep.

#11MagnesiumEvidence · Grade DSafety: watchView remedy

Why it may help Autism Spectrum: Magnesium plays a role in neurotransmitter regulation and neuronal excitability, which may help modulate some behavioral and neurological symptoms associated with autism spectrum disorder.

Typical dose
100-400 mg daily (various forms)
Mechanism
Involved in neurotransmitter function and muscle relaxation, potentially aiding in sleep and reducing irritability.
Notes
Magnesium Glycinate or Magnesium L-Threonate may be preferred for neurological effects.
Evidence
limited
#12ChamomileEvidence · Grade DSafety: watchView remedy

A daisy-like flower that has been studied for mild sedative and digestive effects.

Dietary Protocols

Community outcomes

What people report for Autism Spectrum

Self-reported by community members · not medical advice.

What people report for this condition

Self-reported community outcomes. Not medical advice. Requires at least three reports per remedy to surface.

Total reports

30

Reported worked

60%

Mixed results

13%

Did not work

20%

Top reported helpful approaches

Most reported did not help

Most reported side effects

People Like Me insights

As more members share outcomes, RemedyAtlas will show which remedies helped people with similar conditions, symptoms, goals, and lab patterns.

Community discussion

Structured experience reports from people managing this condition. Not medical advice.

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Community Discussions

What people say about Autism Spectrum

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Lifestyle foundations

  • Structured routines
  • Consistent environment
  • Sensory-friendly spaces
  • Adequate sleep
  • Regular physical activity
  • Stress management techniques
  • Balanced nutrition
  • Social skill development

Dietary recommendations

  • Gluten-free, casein-free diet (for some individuals)
  • Anti-inflammatory diet
  • Increase omega-3 rich foods
  • Limit processed foods
  • Adequate fiber intake
  • Probiotic-rich foods
  • Hydration
  • Nutrient-dense foods

Lifestyle interventions

  • Regular physical activity (e.g., swimming, walking) 30-60 minutes daily
  • Consistent sleep schedule (7-9 hours for adults, more for children) with a 10 pm bedtime
  • Mindfulness or meditation practices 10-20 minutes daily for stress reduction
  • Structured daily routines to provide predictability
  • Sensory integration therapy as recommended by a professional
  • Social skills training with a therapist or group
  • Speech and language therapy as needed
  • Occupational therapy for daily living skills

Evidence at a glance

Moderate Evidence

Omega-3 Fatty AcidsMelatonin

Traditional Use

ChamomileLemon Balm

International evidence & guidelines

How global health authorities view Autism Spectrum.

The Mayo Clinic emphasizes that there is no cure for ASD, but early, intensive, and sustained intervention can make a significant difference. They highlight behavioral and educational therapies as primary treatments. The NIH and NCCIH acknowledge that some complementary health approaches are used by individuals with ASD, but often note a lack of strong scientific evidence for their efficacy and safety. They caution against unproven treatments. The WHO recognizes ASD as a diverse group of conditions and stresses the importance of early diagnosis and evidence-based interventions tailored to individual needs. NHS guidance focuses on behavioral, educational, and communication therapies, and highlights the importance of individualized support plans. Cochrane reviews have examined various interv

Evidence ecosystem

Indexed studies for Autism Spectrum, grouped by source type and quality.

Filter by source type

Meta-Analyses(30)

Pooled analyses across multiple human trials.

Very High Quality
  • Comparative effectiveness of physical activity interventions on cognitive functions in children and adolescents with Neurodevelopmental Disorders: a systematic review and network meta-analysis of randomized controlled trials.

    Tao R, Yang Y, Wilson M, Chang JR, Liu C, Sit CHP · The international journal of behavioral nutrition and physical activity · 2025

    Physical activity (PA) interventions have been shown to yield positive effects on cognitive functions. However, it is unclear which type of PA intervention is the most effective in children and adolescents with Neurodevelopmental Disorders (NDDs). This study aimed to compare the effectiveness of different types of PA interventions on cognitive functions in children and adolescents with NDDs, with additional analyses examining intervention effects across specific NDD types including attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In this systematic review and network meta-analysis, seven databases (Web of Science, PubMed, Medline, APA PsycINFO, Embase, CINAHL, and SPORTDiscus) for randomized controlled trials from database inception to September 2023 were searched. Randomized controlled trials comparing the effectiveness of PA intervention with any non-pharmacological treatment or control group on cognitive functions in children and adolescents diagn

    Meta-AnalysisPubMedVery High Quality
  • Maternal paracetamol (acetaminophen) use during pregnancy and risk of autism spectrum disorder and attention deficit/hyperactivity disorder in offspring: umbrella review of systematic reviews.

    Sheikh J, Allotey J, Sobhy S, Plana MN, Martinez-Barros H, Naidu H · BMJ (Clinical research ed.) · 2025

    To assess the quality, biases, and validity of evidence on maternal paracetamol (acetaminophen) use during pregnancy and the risk of autism spectrum disorder (referred to as autism) and attention deficit/hyperactivity disorder (ADHD) in offspring. Umbrella review of systematic reviews. Medline, Embase, PsycINFO, and the Cochrane Database of Systematic Reviews, along with grey literature, Epistemonikos, and the reference lists of included studies (inception to 30 September 2025). Systematic reviews of randomised trials and cohort, case-control, or cross sectional studies that reported maternal paracetamol use during pregnancy and the diagnosis of autism or ADHD in offspring. Details of the primary studies included in the reviews are reported, including adjustments for key confounders (maternal characteristics, indication for paracetamol use, and familial factors) and unmeasured confounders and ascertainment of outcomes. Nine reviews (40 studies) reporting on autism (six studies) and

    Meta-AnalysisPubMedVery High Quality
  • Association between maternal diabetes and neurodevelopmental outcomes in children: a systematic review and meta-analysis of 202 observational studies comprising 56·1 million pregnancies.

    Ye W, Luo C, Zhou J, Liang X, Wen J, Huang J · The lancet. Diabetes & endocrinology · 2025 · n=98

    Maternal diabetes might alter fetal brain development. However, well-designed systematic analyses are needed to comprehensively assess and quantify the association between maternal diabetes and neurodevelopmental outcomes in children. We aimed to synthesise and evaluate the available evidence on the effects of maternal diabetes on neurodevelopmental outcomes in children. For this systematic review and meta-analysis we searched PubMed, Web of Science, Embase, and EBSCO databases from inception to Dec 1, 2024, for studies exploring neurodevelopmental outcomes of children born to mothers with diabetes. The primary outcome was neurodevelopmental disorders, as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and International Classification of Diseases 11th Revision. Data were extracted from published reports. Data were pooled with random-effects models and presented as risk ratios or standard mean differences with 95% CIs. This study was prospectively re

    Meta-AnalysisPubMedVery High Quality

Systematic Reviews(9)

Structured reviews of the full body of evidence (incl. Cochrane).

Very High Quality
  • The pediatric psychopharmacology of autism spectrum disorder: A systematic review - Part II: The future.

    Persico AM, Asta L, Chehbani F, Mirabelli S, Parlatini V, Cortese S · Progress in neuro-psychopharmacology & biological psychiatry · 2025

    Part I of this systematic review summarized the state-of-the-art of pediatric psychopharmacology for Autism Spectrum Disorder (ASD), a severe and lifelong neurodevelopmental disorder. The purpose of this Part II follow-up article is to provide a systematic overview of the experimental psychopharmacology of ASD. To this aim, we have first identified in the Clinicaltrials.gov website all the 157 pharmacological and nutraceutical compounds which have been experimentally tested in children and adolescents with ASD using the randomized placebo-controlled trial (RCT) design. After excluding 24 drugs already presented in Part I, a systematic review spanning each of the remaining 133 compounds was registered on Prospero (ID: CRD42023476555), performed on PubMed (August 8, 2024), and completed with EBSCO, PsycINFO (psychology and psychiatry literature) and the Cochrane Database of Systematic reviews, yielding a total of 115 published RCTs, including 57 trials for 23 pharmacological compounds an

    Systematic ReviewPubMedVery High Quality
  • Nutraceuticals in Psychiatric Disorders: A Systematic Review.

    Bozzatello P, Novelli R, Montemagni C, Rocca P, Bellino S · International journal of molecular sciences · 2024

    Correct nutrition and diet are directly correlated with mental health, functions of the immune system, and gut microbiota composition. Diets with a high content of some nutrients, such as fibers, phytochemicals, and short-chain fatty acids (omega-3 fatty acids), seem to have an anti-inflammatory and protective action on the nervous system. Among nutraceuticals, supplementation of probiotics and omega-3 fatty acids plays a role in improving symptoms of several mental disorders. In this review, we collect data on the efficacy of nutraceuticals in patients with schizophrenia, autism spectrum disorders, major depression, bipolar disorder, and personality disorders. This narrative review aims to provide an overview of recent evidence obtained on this topic, pointing out the direction for future research.

    Systematic ReviewPubMedVery High Quality
  • Nutritional management and autism spectrum disorder: A systematic review.

    Al-Beltagi M · World journal of clinical pediatrics · 2024

    Autism spectrum disorder (ASD) presents unique challenges related to feeding and nutritional management. Children with ASD often experience feeding difficulties, including food selectivity, refusal, and gastrointestinal issues. Various interventions have been explored to address these challenges, including dietary modifications, vitamin supplementation, feeding therapy, and behavioral interventions. To provide a comprehensive overview of the current evidence on nutritional management in ASD. We examine the effectiveness of dietary interventions, vitamin supplements, feeding therapy, behavioral interventions, and mealtime practices in addressing the feeding challenges and nutritional needs of children with ASD. We systematically searched relevant literature up to June 2024, using databases such as PubMed, PsycINFO, and Scopus. Studies were included if they investigated dietary interventions, nutritional supplements, or behavioral strategies to improve feeding behaviors in children wit

    Systematic ReviewPubMedVery High Quality

Clinical Guidelines(24)

Recommendations from medical societies (NICE, AHA, ADA, ACG, Endocrine Society…).

High Quality
  • Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication: Practice Guideline From the AAN, AES, and SMFM.

    Pack AM, Oskoui M, Williams Roberson S, Donley DK, French J, Gerard EE · Neurology · 2024

    This practice guideline provides updated evidence-based conclusions and recommendations regarding the effects of antiseizure medications (ASMs) and folic acid supplementation on the prevalence of major congenital malformations (MCMs), adverse perinatal outcomes, and neurodevelopmental outcomes in children born to people with epilepsy of childbearing potential (PWECP). A multidisciplinary panel conducted a systematic review and developed practice recommendations following the process outlined in the 2017 edition of the American Academy of Neurology Clinical Practice Guideline Process Manual. The systematic review includes studies through August 2022. Recommendations are supported by structured rationales that integrate evidence from the systematic review, related evidence, principles of care, and inferences from evidence. The following are some of the major recommendations. When treating PWECP, clinicians should recommend ASMs and doses that optimize both seizure control and fetal outco

    Clinical GuidelinePubMed (Practice Guideline)Very High Quality
  • Clinical practice guideline: Interventions for Developmental Language Delay and Disorders.

    Neumann K, Kauschke C, Fox-Boyer A, Lüke C, Sallat S, Kiese-Himmel C · Deutsches Arzteblatt international · 2024

    Approximately 9.9 % of children present with difficulties in language development (DLD), 7.6 % without serious additional impairments and 2.3 % associated with languagerelevant comorbidities, e.g., hearing loss. Notably, in a consensus statement by experts in German-speaking countries, in the guideline presented here, and further in this article, all of these disorders are referred to as "developmental language disorders" (DLD), whereas the international consortium CATALISE only refers to those without comorbidities as DLD. DLDs are among the most commonly treated childhood disorders and, if persistent, often reduce educational and socio-economic outcome. Children in their third year of life with developmental language delay (late talkers, LT) are at risk of a later DLD. This German interdisciplinary clinical practice guideline reflects current knowledge regarding evidence-based interventions for developmental language delay and disorders. A systematic literature review was conducted

    Clinical GuidelinePubMed (Practice Guideline)Very High Quality
  • 2023 clinical practice guidelines on autism spectrum disorder in children and adolescents in Singapore.

    Wong CM, Aljunied M, Chan DKL, Cheong JMY, Chew B, Chin CH · Annals of the Academy of Medicine, Singapore · 2024

    Autism is a neurodevelopmental condition that is increasing in prevalence worldwide. There has been an exponential increase in autism-related research since 2010, when the first Singapore Clinical Practice Guidelines (CPG) on autism was published. Understanding of autism has since evolved to adopt a lifespan approach beyond that of a childhood condition. The aim of this CPG was to provide an updated set of recommendations for children and adolescents to aid clinical practice for professionals. A multidisciplinary workgroup that comprised representatives from various sectors worked on this CPG. Clinical questions were organised into 10 different sections, each with its own subgroup of members. Seventeen existing international guidelines were evaluated using the Appraisal of Guidelines for REsearch & Evaluation II (AGREE-II) framework, of which 4 met criteria to act as references. Literature review across multiple databases was conducted between January 2011 to 2023; Grading of Reco

    Clinical GuidelinePubMed (Practice Guideline)Very High Quality

Randomized Human Trials(13)

Controlled human studies with random assignment.

High Quality
  • Gut microbiome differences in children with Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder and effects of probiotic supplementation: A randomized controlled trial.

    Novau-Ferré N, Papandreou C, Rojo-Marticella M, Canals-Sans J, Bulló M · Research in developmental disabilities · 2025

    Emerging evidence suggests a significant role of gut microbiota on neurodevelopmental disorders, including Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). Our study aimed to compare gut microbiota composition between these disorders and evaluate the effect of probiotic supplementation. We conducted a 12-week randomized, double-blind, placebo-controlled trial with 80 children aged 5-14 years (39 with ADHD, 41 with ASD). Baseline and post-intervention fecal samples were analyzed using 16S rRNA gene sequencing to identify changes in gut microbiota composition. We identified 22 taxa differentiating ADHD and ASD (AUC = 0.939), characterised by increased presence of Clostridia, Ruminococcaceae, and Lachnospiraceae in ADHD, and Bacteroides, Bacilli and Actinobacteria in ASD. These differences remained after accounting for potential confounders. ASD children receiving probiotics had significant increases in Chao 1, Fisher's alpha, and Shannon indices wher

    Randomized TrialPubMedHigh Quality
  • Safety and Efficacy of High-Dose Folinic Acid in Children with Autism: The Impact of Folate Metabolism Gene Polymorphisms.

    Zhang C, Chen Y, Hou F, Li Y, Wang W, Guo L · Nutrients · 2025 · n=50

    Background/Objectives: Research on the safety and efficacy of high-dose folinic acid in Chinese children with autism spectrum disorder (ASD) is limited, and the impact of folate metabolism gene polymorphisms on its efficacy remains unclear. This trial aimed to evaluate the safety and efficacy of high-dose folinic acid intervention in Chinese children with ASD and explore the association between folate metabolism gene polymorphisms and efficacy. Methods: A 12-week randomized clinical trial was conducted, including 80 eligible children with ASD, randomly assigned to an intervention group (n = 50) or a control group (n = 30). The intervention group was administered folinic acid (2 mg/kg/day, max 50 mg/day) in two divided doses. Efficacy was measured using the Psycho-Educational Profile, Third Edition (PEP-3) at baseline and 12 weeks by two trained professionals blind to the group assignments. Methylenetetrahydrofolate reductase (MTHFR C677T, MTHFR A1298C), methionine synthase (MTR A2756G)

    Randomized TrialPubMedHigh Quality
  • Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial.

    Panda PK, Sharawat IK, Saha S, Gupta D, Palayullakandi A, Meena K · European journal of pediatrics · 2024 · n=40

    Oral folinic acid has shown potential to improve symptoms in children with autism spectrum disorder (ASD). However, randomized controlled trials (RCTs) are limited. This double-blind, placebo-controlled RCT aimed to compare changes in Childhood Autism Rating Scale (CARS) scores in children with ASD aged 2-10 years, among folinic acid (2 mg/kg/day, maximum of 50 mg/day) and placebo groups at 24 weeks, in comparison with baseline. Both the groups received standard care (ABA and sensory integration therapy). Secondary objectives included changes in behavioral problems measured by the Child Behavior Checklist (CBCL) and serum levels of anti-folate receptor autoantibodies and folic acid, correlated with changes in autism symptom severity. Out of the 40 participants recruited in each group, 39 and 38 participants completed the 24-week follow-up in the folinic acid and placebo groups, respectively. The change in CARS score was higher in the folinic acid group (3.6 &

    Randomized TrialPubMedHigh Quality

Observational Studies(13)

Cohort, case-control, and cross-sectional human studies.

Moderate Quality
  • Probiotics for autism spectrum disorder: An updated systematic review and meta-analysis of effects on symptoms.

    Soleimanpour S, Abavisani M, Khoshrou A, Sahebkar A · Journal of psychiatric research · 2024

    Recent researches highlighted the significant role of the gut-brain axis and gut microbiota in autism spectrum disorder (ASD), a neurobehavioral developmental disorder characterized by a variety of neuropsychiatric and gastrointestinal symptoms, suggesting that alterations in the gut microbiota may correlate with the severity of ASD symptoms. Therefore, this study was designed to conduct a comprehensive systematic review and meta-analysis of the effectiveness of probiotic interventions in ameliorating behavioral symptoms in individuals with ASD. This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. A comprehensive literature search was performed across multiple databases including the Cochrane Library, PubMed, Web of Science, and Google Scholar up until June 2024. Inclusion criteria encompassed published randomized clinical trials (RCTs), focusing on probiotic interventions and evaluating outcomes related to ASD behavior sympt

    Observational StudyPubMedLow Quality
  • Screening and diagnostic tools for autism spectrum disorder: Systematic review and meta-analysis.

    Santos CLD, Barreto II, Floriano I, Tristão LS, Silvinato A, Bernardo WM · Clinics (Sao Paulo, Brazil) · 2024

    Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder, with main manifestations related to communication, social interaction, and behavioral patterns. The slight dynamics of change in the child over time require that the onset of clinical manifestations presented by the child be more valued, with the aim of stabilizing the condition. Faced with a variety of methods for diagnosing ASD, the question arises as to which method should be used. This systematic review aims to recommend the best tools to perform screening and diagnosis. This systematic review followed the PRISMA guidelines. The databases MEDLINE, Embase, CENTRAL (Cochrane), and Lilacs were accessed, and gray and manual searches were performed. The search strategy was created with terms referring to autism and the diagnosis/broad filter. The studies were qualitatively evaluated and quantitatively. Statistical analysis was performed using Meta-diSc-2.0 software, the confidence interval was 95 %. The M-C

    Observational StudyPubMedLow Quality
  • The impact of the physical activity intervention on sleep in children and adolescents with autism spectrum disorder: A systematic review and meta-analysis.

    Liang X, Haegele JA, Tse AC, Li M, Zhang H, Zhao S · Sleep medicine reviews · 2024

    Pharmacological treatments (i.e., melatonin) and non-pharmacological therapies (e.g., parent-based sleep education programs and behavioural interventions) have been found to result in improved sleep in children and adolescents with autism spectrum disorder (ASD). However, there are several limitations to these treatment approaches, including concerns about the possible side-effects and safety, high-cost and uncertainties of long-term effects. Physical activity (PA) intervention is a promising behavioural intervention that has received increasing attention. However, the effects of PA intervention on sleep are still unclear in this clinical group. This study aimed to synthesize available empirical studies concerning the effects of PA interventions on sleep in children and adolescents with ASD. Following PRISMA guidelines, seven electronic databases: APA PsychInfo, CINAHL Ultimate, ERIC, MEDLINE, PubMed, SPORTDiscus, and Web of Science, were searched from inception to March 2023. Randomiz

    Observational StudyPubMedLow Quality

Government Health Sources(2)

Public-health agencies: NCCIH, NIH, CDC, NHS.

High Quality
  • Autism Spectrum Disorder

    CDC

    This CDC page provides comprehensive information about autism spectrum disorder, including signs and symptoms, diagnosis, treatment, and research.

    Government SourceCDCHigh Quality
  • Autism

    NHS

    The NHS provides an overview of autism, covering symptoms, diagnosis, living with autism, and support available in the UK.

    Government SourceNHSHigh Quality

Clinical Trial Registries(93)

Registered ongoing or completed trials (ClinicalTrials.gov).

Moderate Quality
  • Improving Social Cognition and Error Monitoring in Autism Spectrum Disorder Through a Brain Computer Interface Based on Reinforcement Learning

    n=28 · NCT06829303 · RECRUITING · RECRUITING

    Social cognition seems to develop atypically in autism, particularly in processes such as faces perception, joint attention and social information processing. In this sense, and using an Emotional Paradigm of Facial Expressions (EFP) with a Brain-Computer Interface (BCI) based on Electroencephalography (EEG), the investigators intend to evaluate its effectiveness as a medical device in Autism Spectrum Disorder (ASD), namely: improving 1) social skills and 2) reducing generalized anxiety, 3) improve error monitoring, and consequently verify 4) an increase in motivation. To this end, the investigators will test a gamified intervention (EFP), using personalized feedback in real time. In this gamified interface, there is an artificial agent that learns rules through Reinforcement Learning using the evoked potentials from the participant as they observe the agent's right or wrong actions. The hypothesis is that this approach allows, during the gamified task (EFP), not only the agent/interface to learn, but also the participant through operant conditioning and implicit scrutiny of errors, which makes it particularly interesting for disorders in which error monitoring processes are compromised, as in ASD.

    Clinical TrialClinicalTrials.govModerate Quality
  • A Screen-Refer-Treat (SRT) Model to Promote Earlier Access to ASD Intervention

    n=627 · NCT02409303 · COMPLETED · COMPLETED

    This project will implement and evaluate an innovative healthcare service delivery model designed to promote earlier access to specialized intervention for toddlers with ASD. The Screen-Refer-Treat (SRT) model provides a coordinated and cost-effective approach to early identification and intervention by involving both medical and EI providers, and represents a practical and sustainable strategy for bridging the gap between ASD concerns and ASD intervention.

    Clinical TrialClinicalTrials.govModerate Quality
  • An Online Evaluation of Work Chat: A Virtual Workday Among Employed Autistic Adults

    n=234 · NCT05949086 · COMPLETED · COMPLETED

    This study is aiming to see if it is feasible for the intervention Work Chat to be delivered in a completely online setting to adults with autism spectrum disorder.

    Clinical TrialClinicalTrials.govModerate Quality

Evidence Summaries(2)

Curated cross-source summaries (TRIP Database and similar).

High Quality
  • Cochrane Library: Autism Spectrum Disorder

    Cochrane

    The Cochrane Library provides systematic reviews and meta-analyses on interventions related to autism spectrum disorder. It is a key resource for evidence-based healthcare decisions.

    Evidence SummaryCochraneHigh Quality
  • TRIP Database: Autism Spectrum Disorder

    TRIP Database

    TRIP Database is a clinical search engine designed to allow users to quickly and easily find high-quality research evidence to support their clinical practice, including for autism spectrum disorder.

    Evidence SummaryTRIP DatabaseHigh Quality

Working alongside conventional care

Conventional care for Autism Spectrum Disorder typically involves a multidisciplinary approach, including behavioral therapies (e.g., Applied Behavior Analysis - ABA), speech therapy, occupational therapy, and educational interventions. Medications may be prescribed to manage co-occurring symptoms such as anxiety, hyperactivity, or aggression. Early intervention is often emphasized to support deve

Related conditions

ADHDAnxiety disordersDepressionEpilepsyIntellectual disabilitySleep disordersGastrointestinal issues

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This information is for educational purposes only and should not replace professional medical advice. Individuals with Autism Spectrum Disorder should consult with a qualified healthcare provider for diagnosis, treatment, and management of their condition.

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