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Cancer (Adjunctive Support)

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Last reviewed June 12, 2026 · AI-assisted, human-reviewed

Overview

Natural compounds with the strongest preclinical and emerging clinical evidence for adjunctive cancer support — never a replacement for oncologist-directed care. Many of these interact with chemotherapy and radiation; always coordinate with your oncology team before adding anything.

Cancer is a complex group of diseases characterized by the uncontrolled growth and spread of abnormal cells. It can originate in virtually any organ or tissue and affects millions worldwide, regardless of age, gender, or background. Individuals often seek support for managing symptoms, improving quality of life during treatment, and exploring strategies that may complement conventional therapies. The journey with cancer can involve various physical and emotional challenges.
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When to seek urgent medical care

  • Unexplained lumps or growths anywhere on the body
  • Persistent fatigue unrelated to activity
  • Significant unexplained weight loss or gain
  • Changes in bowel or bladder habits that persist
  • Non-healing sores or unusual bleeding/discharge
  • Persistent pain without clear cause
  • Changes in skin, such as new moles or changes to existing ones

Common symptoms

  • Fatigue
  • Nausea and vomiting
  • Pain
  • Loss of appetite
  • Weight loss
  • Neuropathy
  • Anxiety
  • Depression
  • Sleep disturbances

Possible contributors

  • Genetic mutations
  • Environmental factors (e.g., carcinogens)
  • Lifestyle choices (e.g., smoking, diet)
  • Infections (e.g., HPV, Hepatitis B/C)
  • Chronic inflammation
  • Age

Labs to discuss with your clinician

  • Complete Blood Count (CBC)
  • Comprehensive Metabolic Panel (CMP)
  • Inflammatory markers (e.g., CRP, ESR)
  • Vitamin D levels
  • Iron studies
  • Tumor markers (as indicated by oncologist)
  • Hormone levels (e.g., thyroid, sex hormones, if relevant to cancer type)

All Remedies

Ranked by community outcomes, then evidence grade, Health Voice mentions, and recency.

Remedies

#1CBD (Cannabidiol)Evidence · Grade ASafety: caution80% helpful · 5 reportsView remedy

Why it may help Cancer (Adjunctive Support): Studied (mostly as nabiximols, a THC:CBD spray) for cancer pain refractory to opioids; preliminary evidence for chemotherapy-related anxiety and sleep disruption.

High-dose CBD can inhibit CYP3A4 and CYP2C19 — relevant for many chemotherapies and supportive medications. Always disclose use to the oncology team.

#2Vitamin CEvidence · Grade ASafety: caution80% helpful · 5 reportsView remedy

Why it may help Cancer (Adjunctive Support): Vitamin C has been studied for its potential role in cancer as an adjunctive therapy due to several proposed mechanisms. It may act as an antioxidant, helping to reduce oxidative stress, and is also an essential cofactor for collagen synthesis. Preclinical research suggests that very high doses administered intravenously may exert a pro-oxidant effect, selectively targeting cancer cells.

Individuals with certain conditions, such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, should avoid high-dose intravenous vitamin C due to the risk of hemolysis. Kidney function should be monitored, especially with high-dose regimens, given concerns about oxalate formation and kidney stones in susceptible individuals. Potential interactions with chemotherapy agents are a subject of ongoing research and require careful medical supervision.

#3THC (Tetrahydrocannabinol)Evidence · Grade ASafety: caution60% helpful · 5 reportsView remedy

Why it may help Cancer (Adjunctive Support): Multiple RCTs and meta-analyses show oral THC (dronabinol) and nabilone reduce chemotherapy-induced nausea and vomiting refractory to standard antiemetics, and improve appetite in advanced cancer.

Always coordinate with the oncology team. THC interacts with opioids, benzodiazepines, and CYP3A4-metabolized chemotherapies. Start low, go slow.

Emerging Research

#1Reishi MushroomEvidence · Grade DSafety: caution100% helpful · 5 reportsView remedy

Why it may help Cancer (Adjunctive Support): Reishi mushroom contains compounds such as beta-glucans and triterpenes that have been studied for their potential to modulate immune activity, including natural killer (NK) cells and macrophages, which play a role in the body's defense mechanisms. In preclinical models, components of Reishi mushroom appear to inhibit tumor angiogenesis, suggesting a possible mechanism for adjunctive support in cancer care.

Individuals undergoing chemotherapy or radiation should exercise caution due to potential interactions or additive effects. Reishi may have anticoagulant properties; therefore, it should be used with caution in individuals using blood-thinning medications or prior to surgery. It may lower blood pressure, which could be a consideration for patients already experiencing low blood pressure.

#2TurmericEvidence · Grade DSafety: caution100% helpful · 5 reportsView remedy

Why it may help Cancer (Adjunctive Support): Turmeric, particularly its active compound curcumin, has been studied for its potential to modulate inflammatory pathways such as NF-kB and COX-2. These pathways are often dysregulated in various cancers, suggesting a potential role for turmeric in adjunctive support by influencing these biological processes.

Individuals undergoing chemotherapy or radiation should exercise caution due to potential interactions. High doses may cause gastrointestinal upset. Turmeric may have antiplatelet effects, which could be a consideration for patients at risk of bleeding or those on anticoagulant medications; consultation with a healthcare provider is important.

#3Soursop (Graviola)Evidence · Grade DSafety: caution100% helpful · 5 reportsView remedy

Why it may help Cancer (Adjunctive Support): In vitro studies suggest that certain compounds found in soursop, particularly Annonaceous acetogenins, may inhibit mitochondrial complex I specifically in cancer cells. This proposed mechanism could potentially disrupt energy production within cancerous cells, leading to their reduced viability. However, these effects have primarily been observed in laboratory settings and not reliably demonstrated in living organisms, especially humans.

Long-term or high-dose consumption of soursop, especially its leaves and seeds, has been associated with atypical parkinsonism due to annonacin neurotoxicity. Given the lack of human clinical evidence for anticancer efficacy, its use for this condition carries potential risks without demonstrated benefits. Individuals undergoing cancer treatment should consult their healthcare provider before considering soursop due to potential interactions or adverse effects.

#4Green TeaEvidence · Grade DSafety: caution80% helpful · 5 reportsView remedy

Why it may help Cancer (Adjunctive Support): Green tea, particularly its primary catechin EGCG, has been studied for its potential anticancer properties. Research suggests that EGCG may interfere with cell proliferation, induce apoptosis in cancer cells, and inhibit angiogenesis. This is believed to occur through mechanisms that include antioxidant protection and inhibition of enzymes such as matrix metalloproteinases which are involved in pathways relevant to cancer progression.

While brewed green tea is generally safe, high-dose EGCG extracts have been associated with liver toxicity, which is a particular concern in individuals undergoing cancer treatments that may already impact liver function. Green tea may also interact with certain medications, including some chemotherapy drugs and anticoagulants. It is crucial for individuals with cancer to discuss green tea consumption with their healthcare provider.

#5ResveratrolEvidence · Grade DSafety: caution80% helpful · 5 reportsView remedy

Why it may help Cancer (Adjunctive Support): Resveratrol has been studied for its potential role in activating SIRT1 and mimicking caloric restriction pathways, which may influence cellular processes relevant to cancer. It appears to modulate inflammation and induce cell-cycle arrest in various cancer cell lines. These mechanisms suggest a potential adjunctive role in supporting conventional cancer treatments.

Individuals with hormone-sensitive cancers should exercise caution and consult their oncology team before using resveratrol, as its hormonal effects are complex. Potential interactions with chemotherapy drugs have been investigated, warranting professional medical advice. Mild gastrointestinal upset may occur at higher doses.

#6Milk ThistleEvidence · Grade DSafety: caution80% helpful · 5 reportsView remedy

Why it may help Cancer (Adjunctive Support): Milk thistle, primarily its active compound silymarin, has been studied for its potential antioxidant and anti-inflammatory properties. These actions may help to stabilize hepatocyte membranes and scavenge free radicals, which could be beneficial in supporting liver function during conventional cancer treatments. Silymarin also appears to stimulate liver regeneration and may influence various cellular pathways relevant to cancer development and progression.

Individuals undergoing chemotherapy or radiation should exercise caution due to potential interactions; milk thistle may affect the metabolism of certain drugs. As milk thistle may exhibit estrogenic effects, it is generally advised to be cautious in individuals with hormone-sensitive cancers. Consultation with an oncologist or healthcare professional is crucial before use.

#7Boswellia (Frankincense)Evidence · Grade DSafety: caution80% helpful · 5 reportsView remedy

Why it may help Cancer (Adjunctive Support): Boswellia, specifically its boswellic acids, has been studied for its potential anti-inflammatory actions by inhibiting 5-lipoxygenase, which may be relevant in cancer progression. Research also indicates that compounds like AKBA (acetyl-11-keto-β-boswellic acid) appear to show pro-apoptotic activity in certain cancer cell lines, such as glioma and colorectal cancer, suggesting a possible role in adjunctive cancer support.

While generally well tolerated, boswellia may interact with certain chemotherapy drugs, particularly those metabolized by cytochrome P450 enzymes. Individuals undergoing active cancer treatment should consult their oncologist before use to assess potential interactions and contraindications. Its use in specific populations, such as pregnant or breastfeeding women, or those with severe liver or kidney disease, should be approached with caution.

#8Broccoli Sprouts (Sulforaphane)Evidence · Grade DSafety: caution40% helpful · 5 reportsView remedy

Why it may help Cancer (Adjunctive Support): Sulforaphane, found in broccoli sprouts, appears to influence cellular pathways that are relevant to cancer development and progression. It may act through the activation of the Nrf2 antioxidant pathway, which can promote the detoxification of harmful compounds. Additionally, sulforaphane is studied for its ability to induce phase-II detoxification enzymes, potentially aiding in the elimination of carcinogens.

Individuals undergoing cancer treatment should discuss the use of broccoli sprouts or sulforaphane supplements with their oncologist, particularly due to potential interactions with chemotherapy or radiation therapy. High consumption of raw cruciferous vegetables may impact thyroid function, which could be a consideration for some cancer patients.

Dietary Protocols

Ketogenic DietC

Investigated as an adjunctive metabolic therapy alongside standard oncology care — most evidence is preclinical or early-phase, with some glioma and glioblastoma trials. Should only be used under oncology and dietitian supervision.

Emphasize

Fatty fish (salmon, sardines, mackerel), Pasture-raised eggs, Avocado and olives

Avoid

Sugar and sweetened beverages, Grains and starches (bread, pasta, rice, cereal), Most fruit (except small portions of berries)

View protocol
Anti-Inflammatory DietB

Lower dietary inflammatory index scores are associated with reduced incidence of multiple cancers in large cohorts.

Emphasize

Fatty fish 2–3x/week (salmon, sardines, mackerel, herring), Extra-virgin olive oil, Berries, cherries, and other deeply colored fruit

Avoid

Sugar-sweetened beverages and refined sugar, Ultra-processed snacks and ready meals, Industrial seed oils used at high heat (soybean, corn, sunflower, cottonseed)

View protocol
Vegan DietB

Vegan cohorts show some of the lowest incidence rates of cancer in observational data, particularly for hormone-related and GI cancers.

Emphasize

Legumes (lentils, beans, peas, tofu, tempeh, edamame), Whole grains (oats, barley, quinoa, brown rice), Vegetables and fruit, with leafy greens daily

Avoid

Refined grains and sugar as the bulk of meals, Heavily processed vegan junk foods, Coconut and palm oils in excess

View protocol
Vegetarian DietB

Long-term cohorts (Adventist Health Study, EPIC-Oxford) associate vegetarian patterns with lower incidence of several cancers, especially colorectal.

Emphasize

Legumes (lentils, chickpeas, beans, tofu, tempeh), Whole grains (oats, quinoa, brown rice, whole wheat), Vegetables and fruit, daily and varied

Avoid

Highly processed meat substitutes (occasional only), Sugar-sweetened beverages, Refined grains as the bulk of meals

View protocol

Community outcomes

What people report for Cancer (Adjunctive Support)

Self-reported by community members · not medical advice.

What people report for this condition

Self-reported community outcomes. Not medical advice. Requires at least three reports per remedy to surface.

Total reports

55

Reported worked

80%

Mixed results

11%

Did not work

9%

Top reported helpful approaches

Most reported did not help

Most reported side effects

People Like Me insights

As more members share outcomes, RemedyAtlas will show which remedies helped people with similar conditions, symptoms, goals, and lab patterns.

Community discussion

Structured experience reports from people managing this condition. Not medical advice.

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Community Discussions

What people say about Cancer (Adjunctive Support)

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Lifestyle foundations

  • Prioritize restorative sleep hygiene
  • Engage in regular, moderate physical activity as tolerated
  • Implement stress reduction techniques (e.g., meditation, mindfulness)
  • Consume a nutrient-dense, plant-rich diet
  • Maintain adequate hydration
  • Avoid smoking and excessive alcohol consumption
  • Foster strong social and emotional support networks

International evidence & guidelines

How global health authorities view Cancer (Adjunctive Support).

    Evidence ecosystem

    Indexed studies for Cancer (Adjunctive Support), grouped by source type and quality.

    Filter by source type

    Meta-Analyses(3)

    Pooled analyses across multiple human trials.

    Very High Quality
    • Therapeutic Use of Cannabis and Cannabinoids: A Review.

      Hsu M, Shah A, Jordan A, Gold MS, Hill KP · JAMA · 2026

      Approximately 27% of adults in the US and Canada report having ever used cannabis for medical purposes. An estimated 10.5% of the US population reports using cannabidiol (CBD), a chemical compound extracted from cannabis that does not have psychoactive effects, for therapeutic purposes. Conditions for which cannabinoids have approval from the US Food and Drug Administration include HIV/AIDS-related anorexia, chemotherapy-induced nausea and vomiting, and certain pediatric seizure disorders. A meta-analysis of randomized clinical trials reported a small but significant reduction in nausea and vomiting from various causes (eg, chemotherapy, cancer) when comparing prescribed cannabinoids (eg, dronabinol, nabilone) with placebo or active comparators (eg, alizapride, chlorpromazine; standardized mean difference [SMD], -0.29 [95% CI, -0.39 to -0.18]). A meta-analysis of randomized clinical trials among patients with HIV/AIDS reported that cannabinoids had a moderate effect on increasing body

      Meta-AnalysisPubMedVery High Quality
    • Cannabis-based medicines and medical cannabis for adults with cancer pain.

      Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA · The Cochrane database of systematic reviews · 2023 · n=10

      Pain is a common symptom in people with cancer; 30% to 50% of people with cancer will experience moderate-to-severe pain. This can have a major negative impact on their quality of life. Opioid (morphine-like) medications are commonly used to treat moderate or severe cancer pain, and are recommended for this purpose in the World Health Organization (WHO) pain treatment ladder. Pain is not sufficiently relieved by opioid medications in 10% to 15% of people with cancer. In people with insufficient relief of cancer pain, new analgesics are needed to effectively and safely supplement or replace opioids. To evaluate the benefits and harms of cannabis-based medicines, including medical cannabis, for treating pain and other symptoms in adults with cancer compared to placebo or any other established analgesic for cancer pain. We used standard, extensive Cochrane search methods. The latest search date was 26 January 2023. We selected double-blind randomised, controlled trials (RCT) of medical

      Meta-AnalysisPubMedVery High Quality
    • Nabiximols in Chronic Neuropathic Pain: A Meta-Analysis of Randomized Placebo-Controlled Trials.

      Dykukha I, Malessa R, Essner U, Überall MA · Pain medicine (Malden, Mass.) · 2021 · n=1289

      Pooled analysis of nabiximols and placebo in randomized controlled studies (RCTs) of chronic neuropathic pain. Systematic review and meta-analysis. A systematic literature search was conducted to identify double-blind placebo-controlled RCTs of nabiximols for chronic neuropathic pain. The clinical endpoint of interest was change from baseline in mean pain score on 11-point numerical rating scales. Mean difference (MD) and standardized mean difference (SMD, Hedges' g) were calculated using fixed effect (FE) and random effects (RE) models. Strength of evidence was assessed using the Cochrane Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool. Risk of bias was assessed using the revised Cochrane risk-of-bias tool (RoB 2). Nine RCTs with 1289 participants were included. Quality of evidence (GRADE) was moderate. One study had a high risk of bias (RoB 2) and five had some concerns. For the pooled endpoint of change from baseline in mean pain score, nabiximols w

      Meta-AnalysisPubMedVery High Quality

    Systematic Reviews(1)

    Structured reviews of the full body of evidence (incl. Cochrane).

    Very High Quality
    • Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review.

      Sarris J, Sinclair J, Karamacoska D, Davidson M, Firth J · BMC psychiatry · 2020

      Medicinal cannabis has received increased research attention over recent years due to loosening global regulatory changes. Medicinal cannabis has been reported to have potential efficacy in reducing pain, muscle spasticity, chemotherapy-induced nausea and vomiting, and intractable childhood epilepsy. Yet its potential application in the field of psychiatry is lesser known. The first clinically-focused systematic review on the emerging medical application of cannabis across all major psychiatric disorders was conducted. Current evidence regarding whole plant formulations and plant-derived cannabinoid isolates in mood, anxiety, sleep, psychotic disorders and attention deficit/hyperactivity disorder (ADHD) is discussed; while also detailing clinical prescription considerations (including pharmacogenomics), occupational and public health elements, and future research recommendations. The systematic review of the literature was conducted during 2019, assessing the data from all case studie

      Systematic ReviewPubMedVery High Quality

    Clinical Guidelines(1)

    Recommendations from medical societies (NICE, AHA, ADA, ACG, Endocrine Society…).

    High Quality
    • Cannabis-based medicinal products

      National Institute for Health and Care Excellence (NICE)

      NICE guideline NG144 covers cannabis-based medicinal products for a range of conditions, including chronic pain, nausea and vomiting. It provides recommendations for prescribing and clinical use based on existing evidence.

      Clinical GuidelineNational Institute for Health and Care Excellence (NICE)High Quality

    Randomized Human Trials(4)

    Controlled human studies with random assignment.

    High Quality
    • Cats and cannabinoids: past, present and future.

      Niño Cital S, Wakshlag J, Kennedy A, Tittle D, Petty M · Journal of feline medicine and surgery · 2025

      The use of cannabinoids from hemp, which is classified as a cultivar of Cannabis sativa with up to 0.3% delta-9-tetrahydrocannabinol by USA federal definitions, is becoming increasingly popular in veterinary medicine. Owners frequently ask about their utility in a variety of conditions, including predominantly osteoarthritis, behavioral management, cancer, dermatitis and seizure disorders. Cannabinoid clinical utility, particularly cannabidiol (CBD) in dogs, is gradually emerging, while evidence for its use in cats remains limited. Several newer publications around the pharmacokinetics of CBD and cannabidiolic acid in cats show dramatic differences in bioavailability, elucidating that not all formulations are similar regarding serum or plasma concentrations. To date, although the pharmacokinetics look favorable, there are a handful of clinical studies on feline acute/chronic pain states and fear/anxiety/stress, alongside some pre-clinical studies where there is a potential for clinical

      Randomized TrialPubMedHigh Quality
    • Oral Cannabis Extract for Secondary Prevention of Chemotherapy-Induced Nausea and Vomiting: Final Results of a Randomized, Placebo-Controlled, Phase II/III Trial.

      Grimison P, Mersiades A, Kirby A, Tognela A, Olver I, Morton RL · Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024 · n=250

      The aim of this randomized, placebo-controlled, two-stage, phase II/III trial was to determine the efficacy of an oral cannabis extract in adults with refractory nausea and/or vomiting during moderately or highly emetogenic, intravenous chemotherapy despite guideline-consistent antiemetic prophylaxis. Here, we report results of the prespecified combined analysis including the initial phase II and subsequent phase III components. Study treatment consisted of oral capsules containing either tetrahydrocannabinol 2.5 mg plus cannabidiol 2.5 mg capsules (THC:CBD) or matching placebo, taken three times a day from days -1 to 5, in addition to guideline-consistent antiemetics. The primary measure of effect was the difference in the proportions of participants with no vomiting or retching and no use of rescue medications (a complete response) during hours 0-120 after the first cycle of chemotherapy on study (cycle A). We recruited 147 evaluable of a planned 250 participants from 2016 to 2022.

      Randomized TrialPubMedHigh Quality
    • Cannabidiol for Scan-Related Anxiety in Women With Advanced Breast Cancer: A Randomized Clinical Trial.

      Nayak MM, Chai P, Catalano PJ, Pirl WF, Tulsky JA, Tung SC · JAMA network open · 2024 · n=50

      Early evidence from studies outside of oncology has suggested that cannabidiol (CBD) may have anxiolytic effects without neuropsychiatric risks. An understanding of oral CBD in patients with cancer-related anxiety is urgently needed. To determine whether a single 400-mg oral dose of a US Food and Drug Administration-approved CBD improves clinical anxiety in an oncologic population. This phase II, double-masked, placebo-controlled, randomized clinical trial was performed at the Dana-Farber Cancer Institute's Breast Oncology Center from November 2, 2021, through March 1, 2023. Women aged 18 years or older with advanced breast cancer and baseline clinical anxiety were included. Patients were randomized 1:1 to receive oral CBD, 400 mg, vs placebo within 48 hours before a scan assessing tumor burden. The primary end point was a between-arm comparison of change scores on the afraid subscale of the Visual Analog Mood Scale (VAMS) before and 2 to 4 hours after study drug ingestion. The VAM

      Randomized TrialPubMedHigh Quality

    Observational Studies(52)

    Cohort, case-control, and cross-sectional human studies.

    Moderate Quality
    • Tetrahydrocannabinol (THC).

      Ng T, Gupta V, Keshock MC · 2026

      Observational StudyPubMedLow Quality
    • Dronabinol.

      O'Donnell B, Meissner H, Gupta V · 2026

      Observational StudyPubMedLow Quality
    • Cannabidiol Suppresses EMT in Pancreatic Cancer via Inhibition of MALAT1 lncRNA and PI3K/Akt/mTOR Signaling Pathway.

      Kim NY, Jung YY, Um JY, Ahn KS · IUBMB life · 2025

      Pancreatic ductal adenocarcinoma (PDAC) is characterized by aggressive metastasis and poor response to chemotherapy, largely driven by epithelial-mesenchymal transition (EMT) and chemokine signaling. Cannabidiol (CBD), a non-psychoactive phytocannabinoid, has shown anticancer potential, yet its mechanisms in EMT regulation remain underexplored in PDAC. In this study, we demonstrate that CBD significantly suppresses the expression of CXCR4/CXCR7 and matrix metalloproteinases (MMP-2/9), leading to reduced migration and invasion of MIA PaCa-2, PANC-1, and AsPC-1 cells. Moreover, CBD reversed CXCL12-induced EMT by downregulating mesenchymal markers and restoring epithelial markers. Mechanistically, CBD inhibited the expression of the long non-coding RNA MALAT1, a known EMT regulator, and antagonized its pro-invasive effects. Overexpression of MALAT1 activated the PI3K/Akt/mTOR pathway and enhanced EMT-related protein expression, all of which were effectively reversed by CBD. Furthermore, t

      Observational StudyPubMedLow Quality

    Mechanistic Studies(1)

    Lab and in-vitro work explaining how something might work.

    Low Quality
    • Cannabidiol suppresses proliferation and induces cell death, autophagy and senescence in human cholangiocarcinoma cells via the PI3K/AKT/mTOR pathway.

      Pongking T, Intuyod K, Thongpon P, Thanan R, Sitthirach C, Chaidee A · Journal of traditional and complementary medicine · 2024

      Cholangiocarcinoma (CCA) is usually diagnosed at a late stage, leading to treatment failure. Cannabidiol (CBD), exhibits diverse anti-cancer effects in various cancers, offering avenues for improving CCA treatment. This study investigated the effects of CBD on human CCA cells and the underlying mechanisms in vitro and in vivo. The effects of CBD on three CCA cell lines (KKU-213B, KKU-100, KKU-055) were assessed using the SRB assay, clonogenic assay, cell cycle arrest, and 3D holotomography. Morphological changes were examined using transmission electron microscopy, while mitochondrial ROS levels and mitochondrial membrane potential were studied using MitoSOX, JC-1, and DCFH-DA. Cellular senescence induction was evaluated via SA-β-gal staining. Protein associatedwith autophagy and cellular senescence were analyzed using Western blot and/or immunofluorescent assays. A xenograft model demonstrated the anti-tumor activity of CBD and the induction of cellular senescence through immun

      Mechanistic StudyPubMedLow Quality

    Animal Studies(4)

    Preclinical animal research — not a substitute for human evidence.

    Low Quality
    • Antitumor effects of cannabidiol (CBD) on osteosarcoma by targeting TNF-α/NF-κB/CCL5 signaling axis.

      Yang F, Duan S, Liu J, An Z, Liu W, Wang X · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2025

      Osteosarcoma remains a therapeutic challenge due to its aggressive behavior and high metastatic potential, necessitating exploration of novel treatment modalities. Cannabidiol (CBD), a non-psychoactive phytocannabinoid with emerging anticancer properties, has shown promise in preclinical cancer models. However, its mechanisms of action in osteosarcoma remain incompletely understood. This study systematically investigates the antitumor effects of CBD on osteosarcoma and elucidates its molecular targets within the TNF-α/NF-κB/CCL5 signaling axis. The effective concentration of CBD was determined using the CCK-8 assay. Functional assays (EdU proliferation, Transwell migration/invasion, and scratch wound healing) evaluated its impact on osteosarcoma cell malignancy. A mouse xenograft model assessed in vivo efficacy. Network pharmacology and RNA-seq identified key pathways, which were validated via ELISA, qRT-PCR, and western blot. Molecular interactions were confirmed through

      Animal StudyPubMedLow Quality
    • Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis Mice.

      Sun Q, Bravo Iniguez A, Tian Q, Du M, Zhu MJ · Molecular nutrition & food research · 2024

      Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut, accompanied by impaired epithelial integrity, increased macrophage infiltration, and enhanced colon cancer risk. Cannabidiol (CBD), a phytocannabinoid isolated from cannabis plants, is supplemented into mice diet, and its beneficial effects against dextran sulfate sodium (DSS)-induced experimental colitis is evaluated. Eight-week-old mice were fed a standard diet supplemented with or without CBD (200 mg kg-1 ) for 5 weeks. In the 4th week of dietary treatment, mice were subjected to 2.5% DSS induction for 7 days, followed by 7 days of recovery, to induce colitis. CBD supplementation reduced body weight loss, gross bleeding, fecal consistency, and disease activity index. In addition, CBD supplementation protected the colonic structure, promoted tissue recovery, and ameliorated macrophage infiltration in the colonic tissue, which was associated with the activation of cyclic AMP-protein kinase A, e

      Animal StudyPubMedLow Quality
    • Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2.

      Xiong X, Chen S, Shen J, You H, Yang H, Yan C · Signal transduction and targeted therapy · 2022

      The combination of immune checkpoint blockade (ICB) with chemotherapy significantly improves clinical benefit of cancer treatment. Since chemotherapy is often associated with adverse events, concomitant treatment with drugs managing side effects of chemotherapy is frequently used in the combination therapy. However, whether these ancillary drugs could impede immunotherapy remains unknown. Here, we showed that ∆9-tetrahydrocannabinol (THC), the key ingredient of drugs approved for the treatment of chemotherapy-caused nausea, reduced the therapeutic effect of PD-1 blockade. The endogenous cannabinoid anandamide (AEA) also impeded antitumor immunity, indicating an immunosuppressive role of the endogenous cannabinoid system (ECS). Consistently, high levels of AEA in the sera were associated with poor overall survival in cancer patients. We further found that cannabinoids impaired the function of tumor-specific T cells through CNR2. Using a knock-in mouse model expressing a FLAG-tagg

      Animal StudyPubMedLow Quality

    Government Health Sources(4)

    Public-health agencies: NCCIH, NIH, CDC, NHS.

    High Quality
    • Cancer

      WHO

      The WHO provides global health information and statistics on cancer, outlining key facts, risk factors, prevention strategies, and approaches to cancer care, including supportive interventions.

      Government SourceWHOHigh Quality
    • Coping With Cancer: Support for Patients, Families, and Caregivers

      NIH National Cancer Institute

      This section of the National Cancer Institute website provides extensive information and resources on coping with cancer, including emotional, practical, and social support. It covers topics such as managing side effects, financial issues, and communication with healthcare teams.

      Government SourceNIH National Cancer InstituteHigh Quality
    • Complementary and Alternative Medicine (CAM)

      National Cancer Institute (NCI)

      This section of the NCI website provides information on complementary and alternative medicine approaches for cancer patients, detailing their potential benefits and risks.

      Government SourceNational Cancer Institute (NCI)High Quality

    Clinical Trial Registries(41)

    Registered ongoing or completed trials (ClinicalTrials.gov).

    Moderate Quality

    Evidence Summaries(7)

    Curated cross-source summaries (TRIP Database and similar).

    High Quality
    • Cochrane reviews on adjunctive therapies for cancer

      Cochrane

      Cochrane provides systematic reviews and meta-analyses of healthcare interventions, offering high-quality evidence on various adjunctive therapies used in cancer care to support clinical decision-making.

      Evidence SummaryCochraneHigh Quality
    • Cochrane Library (Cancer)

      Cochrane

      The Cochrane Library provides high-quality, independent evidence to inform healthcare decision-making, including systematic reviews relevant to various aspects of cancer and adjunctive support.

      Evidence SummaryCochraneHigh Quality
    • TRIP Database (Cancer)

      TRIP Database

      The TRIP Database is a clinical search engine designed to allow users to quickly and easily find high-quality research evidence to support their practice, including numerous resources on cancer and its supportive care.

      Evidence SummaryTRIP DatabaseHigh Quality

    Working alongside conventional care

    Conventional cancer care typically involves a multi-modal approach, which may include surgery, chemotherapy, radiation therapy, immunotherapy, and targeted drug therapies. Diagnoses are commonly established through biopsies, imaging studies, and blood tests, with treatment plans tailored to the specific type, stage, and location of the cancer. These treatments aim to remove, destroy, or control cancer cells.

    Related conditions

    Chemotherapy-induced nausea and vomitingCancer-related fatigueCancer painCachexiaPeripheral neuropathyLymphedema

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    The information provided is for educational purposes only and should not be considered medical advice. Always consult with your oncology team before starting, stopping, or changing any adjunctive therapies, as they can interact with conventional treatments.

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