Most recognized for its studied role in anti-aging and cardiovascular health, often linked to red wine.
Evidence · Grade D
Meta-analysis availableSystematic review availableHuman trial evidenceTraditional useInteraction riskNeeds more research
Polyphenol from grape skins, Japanese knotweed, and red wine studied for longevity, cardiovascular, and chemopreventive effects.
Resveratrol is a natural polyphenol produced by several plants, including grapes, berries, and peanuts, as a defense mechanism against stressors. It has gained attention for its potential antioxidant and anti-inflammatory properties, and is commonly studied for its possible role in anti-aging and cardiovascular health. People typically consume resveratrol through diet or as a dietary supplement, often in capsule form. Its use is frequently inspired by the 'French paradox' – the observation of lower rates of heart disease in France despite a diet high in saturated fats, attributed in part to red wine consumption.
Quick answer
What it is: Resveratrol is a natural polyphenol produced by several plants, including grapes, berries, and peanuts, as a defense mechanism against stressors.
The current evidence base for resveratrol includes numerous preclinical studies, some human clinical trials, and observational research. However, many human studies are small, have short durations, or show inconsistent results. The grade reflects promising early findings, but a lack of conclusive, high-quality human data to firmly establish efficacy for specific health conditions.
Last reviewed · Jun 2026
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Commonly Combined With
Other remedies frequently used alongside this one — from curated relationships, community reports, and shared protocols.
Community signal breakdown
Where this remedy is being discussed across the web and community.
Dietary protocols studied for the conditions this remedy is associated with.
Anti-Inflammatory Diet
A whole-foods pattern designed to lower chronic, low-grade inflammation by emphasizing omega-3s, polyphenols, fiber, and minimizing ultra-processed foods, sugar, and seed oils.
The anti-inflammatory diet is not a single protocol but a synthesis of the patterns most consistently linked to lower inflammatory markers (CRP, IL-6, TNF-alpha) in human studies — Mediterranean-style eating, oily fish, abundant polyphenols, and low intake of ultra-processed foods, refined sugar, industrial seed oils, and excessive alcohol.
Foods to emphasize
Fatty fish 2–3x/week (salmon, sardines, mackerel, herring)
Extra-virgin olive oil
Berries, cherries, and other deeply colored fruit
Dark leafy greens and cruciferous vegetables
Turmeric, ginger, and culinary herbs
Green tea
Nuts (especially walnuts) and seeds (flax, chia)
Legumes and whole grains
Dark chocolate (≥70% cocoa) in moderation
Foods to avoid
Sugar-sweetened beverages and refined sugar
Ultra-processed snacks and ready meals
Industrial seed oils used at high heat (soybean, corn, sunflower, cottonseed)
Processed and cured meats
Refined flour products
Excess alcohol
Key principles
Cook with olive oil, finish with extra-virgin olive oil
Aim for 25–35 g of fiber per day from whole foods
Eat the rainbow — color diversity ~ polyphenol diversity
Limit added sugar to <25 g/day
Typical duration: A long-term eating pattern.
Why it may help
Beauty & Anti-Aging: Polyphenol- and omega-3-rich diets are linked with better skin elasticity, hydration, and reduced photoaging markers.
Skin Care: Reduces inflammatory drivers of acne, rosacea, and eczema; commonly recommended alongside topical care.
Cancer (Adjunctive Support): Lower dietary inflammatory index scores are associated with reduced incidence of multiple cancers in large cohorts.
Insulin Resistance: Reduces chronic low-grade inflammation that impairs insulin signaling.
Type 2 Diabetes: Reduces systemic inflammation that drives insulin resistance and beta-cell dysfunction.
Safe and flexible. Can be combined with Mediterranean, vegetarian, or plant-forward patterns.
Ketogenic Diet
Very-low-carbohydrate, high-fat eating pattern that shifts the body into ketosis, using ketones from fat as a primary fuel.
A classical ketogenic diet typically provides ~70–80% of calories from fat, ~15–20% from protein, and only ~5–10% (often 20–50 g/day) from carbohydrates. The metabolic shift to ketosis lowers blood glucose and insulin, raises ketone bodies (beta-hydroxybutyrate, acetoacetate), and is being studied for neurological and metabolic conditions. Variants include the Modified Atkins Diet (MAD), Medium-Chain Triglyceride (MCT) ketogenic diet, and the Low Glycemic Index Treatment (LGIT).
Foods to emphasize
Fatty fish (salmon, sardines, mackerel)
Pasture-raised eggs
Avocado and olives
Extra-virgin olive oil, coconut oil, MCT oil
Grass-fed meat and poultry
Full-fat dairy (butter, ghee, hard cheeses)
Nuts and seeds (macadamia, pecan, walnut, chia, flax)
Low-carb leafy greens and cruciferous vegetables
Bone broth and electrolyte-rich foods
Foods to avoid
Sugar and sweetened beverages
Grains and starches (bread, pasta, rice, cereal)
Most fruit (except small portions of berries)
Legumes and beans
Starchy vegetables (potatoes, corn, peas)
Low-fat or sweetened dairy
Vegetable seed oils (soybean, corn, sunflower) in excess
Most processed and packaged foods
Key principles
Carbohydrate intake usually 20–50 g net carbs per day
Adequate protein (~1.2–1.7 g/kg) — not high-protein
Most calories from whole-food fats
Track electrolytes (sodium, potassium, magnesium) to prevent "keto flu"
Best initiated with clinician guidance if on medications for diabetes, blood pressure, or seizures
Typical duration: Often 3–6 months minimum to assess response; medically supervised protocols (e.g. for epilepsy) may be maintained for years.
Why it may help
Cancer (Adjunctive Support): Investigated as an adjunctive metabolic therapy alongside standard oncology care — most evidence is preclinical or early-phase, with some glioma and glioblastoma trials. Should only be used under oncology and dietitian supervision.
Type 2 Diabetes: Significant HbA1c and fasting glucose reductions in clinical trials. Monitor diabetes medications closely to avoid hypoglycemia.
Insulin Resistance: Most direct mechanism — lowers insulin demand by minimizing carbohydrate load.
Ketogenic therapy is a medical intervention when used for seizure disorders or oncology — work with a clinician or registered dietitian experienced in ketogenic therapy. Not recommended in pregnancy, type 1 diabetes without supervision, pancreatitis, certain fatty-acid oxidation disorders, or active eating disorders.
Vegan Diet
A fully plant-based eating pattern that excludes all animal products — meat, fish, dairy, eggs, and honey.
A whole-food vegan diet emphasizes vegetables, fruit, legumes, whole grains, nuts, and seeds. It has been associated with improvements in body weight, blood lipids, and glycemic control, and is being studied for autoimmune and inflammatory conditions. It requires deliberate planning for vitamin B12, vitamin D, omega-3 (EPA/DHA), iodine, iron, zinc, and (sometimes) calcium.
Nuts and seeds (especially walnuts, chia, flax, hemp)
Fortified plant milks and nutritional yeast
Algae-based EPA/DHA supplement
Vitamin B12 supplement (non-negotiable)
Foods to avoid
Refined grains and sugar as the bulk of meals
Heavily processed vegan junk foods
Coconut and palm oils in excess
Key principles
B12 supplementation is required, not optional
Include a reliable iodine source (iodized salt or seaweed in moderation)
Get vitamin D from sun and/or a supplement
Combine grains and legumes across the day for complete protein
Choose calcium-fortified plant milk if not eating leafy greens daily
Typical duration: A long-term eating pattern.
Why it may help
Cancer (Adjunctive Support): Vegan cohorts show some of the lowest incidence rates of cancer in observational data, particularly for hormone-related and GI cancers.
Skin Care: Eliminating dairy has reduced acne severity in clinical studies; whole-food vegan diets push this further with high antioxidant intake.
Type 2 Diabetes: Improves insulin sensitivity, supports weight loss, and lowers CV risk in T2D. Supplement B12.
Vegan diets can be excellent or deficient — quality depends on planning. Pregnant, breastfeeding, and growing children on vegan diets should be followed by a registered dietitian.
Vegetarian Diet
A plant-based eating pattern that excludes meat, poultry, and fish but typically allows eggs and/or dairy.
Vegetarian diets range from lacto-ovo (includes eggs and dairy) to lacto (dairy only) and ovo (eggs only). Done well, they are associated with lower rates of cardiovascular disease, type 2 diabetes, and some cancers. Done poorly, they can be high in refined grains and low in key nutrients (B12, iron, omega-3s, zinc).
Foods to emphasize
Legumes (lentils, chickpeas, beans, tofu, tempeh)
Whole grains (oats, quinoa, brown rice, whole wheat)
Vegetables and fruit, daily and varied
Nuts and seeds (almonds, walnuts, chia, flax, hemp)
Plan for protein at every meal (legumes, tofu, tempeh, eggs, dairy)
Pair iron-rich plants with vitamin C to boost absorption
Plan a reliable B12 source — fortified foods or a supplement
Include omega-3 ALA from flax, chia, walnuts; consider an algae-based EPA/DHA supplement
Typical duration: A long-term eating pattern.
Why it may help
Cancer (Adjunctive Support): Long-term cohorts (Adventist Health Study, EPIC-Oxford) associate vegetarian patterns with lower incidence of several cancers, especially colorectal.
Beauty & Anti-Aging: High intake of plant antioxidants is linked with better skin antioxidant capacity and lower oxidative stress markers in observational studies.
Nutritional adequacy depends on planning, not just food choice. A registered dietitian can help avoid common gaps.
Autoimmune Protocol (AIP)
A strict elimination version of paleo designed to calm autoimmune flares and identify food triggers through structured reintroduction.
The Autoimmune Protocol removes foods commonly implicated in immune activation and gut permeability — grains, legumes, dairy, eggs, nightshade vegetables, nuts, seeds, refined sugar, alcohol, and additives — for a 30–90 day elimination, followed by careful one-at-a-time reintroduction. It is most studied in Hashimoto's thyroiditis and inflammatory bowel disease.
Foods to emphasize
Quality meat, poultry, and seafood (especially wild-caught fatty fish)
Organ meats once or twice weekly
A wide variety of non-nightshade vegetables and leafy greens
Nuts and seeds (including seed-based spices like cumin, coriander)
Refined sugar and sweeteners
Alcohol
NSAIDs and food additives where possible
Key principles
Pair the elimination with sleep, stress management, and movement
Track symptoms in a journal during reintroductions
Reintroduce one food every 5–7 days and watch for symptom changes
Most people do NOT need to stay strict long-term — the goal is a personalized maintenance diet
Typical duration: 30–90 day strict elimination, then a structured staged reintroduction over weeks to months.
Why it may help
Skin Care: Used as an elimination protocol for chronic eczema, psoriasis, and autoimmune skin conditions where food triggers are suspected.
AIP is restrictive and best done with a practitioner familiar with the protocol, especially when active autoimmune disease is involved or in pregnancy/lactation.
Carnivore Diet
An all-animal-foods elimination diet consisting of meat, fish, eggs, and (optionally) dairy, with zero plant foods.
The carnivore diet is the most aggressive elimination diet — it removes every plant food (and therefore every fiber, lectin, oxalate, gluten, and FODMAP source) to isolate animal-food tolerance. Proponents use it primarily as a short-term diagnostic elimination to surface food triggers in autoimmune, gut, and inflammatory conditions. Long-term safety data is limited and observational.
Foods to emphasize
Ruminant meat (beef, lamb, bison) — emphasized for nutrient density
Pasture-raised eggs
Fatty fish (salmon, sardines)
Organ meats (liver, kidney) once or twice weekly
Bone broth and bone marrow
Animal fats (tallow, butter, ghee)
Salt to taste
Optional: aged hard cheeses, heavy cream
Foods to avoid
All grains, legumes, and seeds
All vegetables and fruit
Nuts and plant oils
Sugar and sweeteners
Most processed foods
Alcohol
Key principles
Eat to satiety — no calorie counting
Salt food liberally to maintain electrolytes
Prioritize fattier cuts over lean meats
Reintroduce foods one at a time after the elimination window to identify triggers
Best tracked with a clinician given the radical nature of the change
Typical duration: Typically run as a 30–90 day elimination, then food reintroductions one at a time.
Why it may help
Skin Care: Reported anecdotally to clear chronic skin inflammation by removing common food triggers; used as a short diagnostic elimination, not a long-term plan.
Long-term effects on cardiovascular markers, bone health, and the gut microbiome are not well established. Avoid in chronic kidney disease, gout flares, or active eating disorders without medical supervision.
Linked nutrient deficiencies
Vitamin and mineral deficiencies commonly associated with the conditions this remedy may support.
Vitamin C
Water-soluble vitamin
Antioxidant required for collagen synthesis, immune function, and iron absorption.
Low zinc is linked to recurrent infections, acne, slow wound healing, leaky gut, and impaired taste/smell. Often deficient in vegetarians and those with gut malabsorption.
Common symptoms
Frequent colds/infections
Acne or slow-healing skin
Loss of taste or smell
Hair loss
White spots on nails
Food sources
Oysters
Beef and lamb
Pumpkin seeds
Cashews
Lentils and chickpeas
Lab markers to discuss
Plasma or serum zinc
Zinc/copper ratio
Reference intake: 8–11 mg/day RDA.
Supplementation notes: Take away from iron and calcium. Long-term high-dose zinc depletes copper — pair with ~1 mg copper if dosing >30 mg/day.
Why it matters here
Skin Care: Low zinc is implicated in acne, eczema, and slow wound healing.
Beauty & Anti-Aging: Required for wound healing and collagen formation.
Vitamin D
Fat-soluble vitamin
Hormone-like vitamin central to immune function, mood, bone, and thyroid health.
Low vitamin D status is one of the most widespread deficiencies globally and has been linked to autoimmune disease activity (Hashimoto's, MS), mood disorders, recurrent infections, and poor skin barrier function.
Common symptoms
Fatigue
Low mood
Frequent infections
Bone or muscle aches
Hair thinning
Food sources
Fatty fish (salmon, sardines)
Egg yolks
Cod liver oil
UV-exposed mushrooms
Fortified dairy
Lab markers to discuss
25-hydroxyvitamin D (target 40–60 ng/mL per most functional ranges)
Reference intake: Adults 600–800 IU/day RDA; functional medicine often targets 2,000–5,000 IU/day with monitoring.
Supplementation notes: Take with a fat-containing meal. Pair with vitamin K2 (MK-7) when supplementing higher doses long-term.
Why it matters here
Cancer (Adjunctive Support): Observational and some interventional data link adequate vitamin D to improved outcomes in several cancers.
Skin Care: Supports skin barrier and immune balance.
Beauty & Anti-Aging: Influences skin barrier function and pigmentation pathways.
Vitamin A (Retinol)
Fat-soluble vitamin
Required for epithelial integrity, immune defense, vision, and skin renewal.
Selenium reduces TPO antibodies in Hashimoto's and supports T4→T3 conversion. Deficiency is implicated in thyroid autoimmunity and viral susceptibility.
Resveratrol appears to influence cellular pathways associated with longevity and cellular stress response, mimicking some effects of caloric restriction.
How it works in more detail
Preclinical studies suggest resveratrol activates Sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK), which are key regulators of metabolism and cellular defense. It appears to modulate inflammatory pathways, including NF-κB, and may exhibit antioxidant effects by scavenging free radicals and upregulating endogenous antioxidant enzymes. Resveratrol has also been studied for its ability to impact cell cycle arrest and apoptosis in various cell lines, primarily in vitro.
How to use
Always consult a qualified clinician.
Editorial guidance
Suggested dosage
150–500 mg/day trans-resveratrol with food.
Research dosage range
150–1500 mg/day, often as trans-resveratrol
Typical onset
Effects of resveratrol, particularly those related to chronic conditions or anti-aging pathways, are generally not acute and may require weeks to months of consistent supplementation to become apparent, if at all.
Typical forms
capsule, powder
Quality markers
A quality resveratrol supplement may be standardized to contain a specific percentage of trans-resveratrol, which is considered the more bioactive form. Manufacturers often specify the source (e.g., Japanese knotweed, red grape skin). Third-party testing for purity, potency, and absence of contaminants can indicate a higher-quality product.
General guidance — discuss specifics with a clinician.
Evidence ecosystem
Scientific literature, clinical guidance, government sources, ongoing research, traditional use, and lived experience — grouped by source type and quality.
Overall grade (D)
The current evidence base for resveratrol includes numerous preclinical studies, some human clinical trials, and observational research. However, many human studies are small, have short durations, or show inconsistent results. The grade reflects promising early findings, but a lack of conclusive, high-quality human data to firmly establish efficacy for specific health conditions.
Zhou P, Yu X, Song T, Hou X · PloS one · 2024 · n=650
To systematically evaluate the safety and efficacy of antioxidant therapy in children and adolescents with attention deficit hyperactivity disorder (ADHD).
Randomized controlled trials and prospective studies on antioxidant therapy in children and adolescents with ADHD were searched in PubMed, Embase, and Cochrane Library from the inception of databases to November 12, 2022. Two investigators independently screened the literature, extracted data, and evaluated the quality of the included studies. Network meta-analysis (PROSPERO registration number CRD 42023382824) was carried out by using R Studio 4.2.1.
48 studies involving 12 antioxidant drugs (resveratrol, pycnogenol, omega-3, omega-6, quercetin, phosphatidylserine, almond, vitamin D, zinc, folic acid, ginkgo biloba, Acetyl-L-carnitine) were finally included, with 3,650 patients. Network meta-analysis showed that omega-6 (0.18), vitamin D (0.19), and quercetin (0.24) were the top three safest drugs according to SUCRA. The omega-3
Ali Fadlalmola H, Elhusein AM, Al-Sayaghi KM, Albadrani MS, Swamy DV, Mamanao DM · The Pan African medical journal · 2023 · n=218
Polycystic ovarian syndrome (PCOS) is a metabolic and hormonal condition affecting women of a reproductive age. It causes an abnormal menstrual cycle, anovulation, infertility, acne, hirsutism, obesity, hyperlipidemia, and cardiovascular disorders. Because resveratrol decreases testosterone levels, it may be of value in treating PCOS. We aimed to evaluate the efficacy of resveratrol in treating women with PCOS. We searched for randomized clinical trials (RCTs) in PubMed, Cochrane CENTRAL, Scopus and Web of Science. With 95% confidence intervals, the data was retrieved and analyzed as a mean difference (MD) or a standardized mean difference (SMD). Four RCTs with 218 women were included in the analysis. Resveratrol significantly reduced testosterone (SMD = -0.40; 95% CI [-0.71, -0.10], P = 0.009), luteinizing hormone (LH) (SMD = -0.32; 95% CI [-0.62, 0.01], P = 0.04), and dehydroepiandrosterone sulfate (DHEAS) (MD = -0.85; 95% CI [-1.25, -0.45], P < 0.0001) compared with the placebo.
Yang K, Chen J, Zhang T, Yuan X, Ge A, Wang S · Frontiers in immunology · 2022 · n=173
Dietary polyphenol treatment of non-alcoholic fatty liver disease (NAFLD) is a novel direction, and the existing clinical studies have little effective evidence for its therapeutic effect, and some studies have inconsistent results. The effectiveness of dietary polyphenols in the treatment of NAFLD is still controversial. The aim of this study was to evaluate the therapeutic efficacy of oral dietary polyphenols in patients with NAFLD.
The literature (both Chinese and English) published before 30 April 2022 in PubMed, Cochrane, Medline, CNKI, and other databases on the treatment of NAFLD with dietary polyphenols was searched. Manual screening, quality assessment, and data extraction of search results were conducted strictly according to the inclusion and exclusion criteria. RevMan 5.3 software was used to perform the meta-analysis.
The RCTs included in this study involved dietary supplementation with eight polyphenols (curcumin, resveratrol, naringenin, anthocyanin, hesperidin, catech
Meta-AnalysisPubMedVery High Quality
Systematic Reviews(1)
Structured reviews of the full body of evidence (incl. Cochrane).
Ranneh Y, Bedir AS, Abu-Elsaoud AM, Al Raish S · Nutrients · 2024
Non-alcoholic fatty liver disease (NAFLD) has recently emerged as a challenging metabolic disorder with a strong emphasis on its prevention and management. Polyphenols, a group of naturally occurring plant compounds, have been associated with a decreased risk of various metabolic disorders related to NAFLD. The current systematic review aims to critically assess evidence about the ameliorative effect of polyphenol supplementation on NAFLD patients. A PRISMA systematic search appraisal was conducted in PubMed, Scopus, Web of Science Core Collection, and all relevant studies published prior to April 2024 and met the inclusion criteria were included. Twenty-nine randomized clinical trials (RCTs) comprised 1840 NAFLD patients. The studies primarily examined eleven phenolic compounds, including turmeric, curcumin, resveratrol, genistein, catechin, green tea extract, hesperidin, and silymarin. Turmeric and curcumin decreased liver enzymes, inflammatory cytokines, lipid profile, insulin resis
Erol Doğan Ö, Karaca Çelik KE, Baş M, Alan EH, Çağın YF · Nutrients · 2024
This study aimed to investigate the effects of the Mediterranean diet (MD), combined with curcumin and resveratrol supplementation, on disease activity, serum inflammatory markers, and quality of life in patients with mild-to-moderate active ulcerative colitis (UC). This study was designed as a prospective multicenter three-arm randomized controlled trial. Participants were randomized to the MD, MD + curcumin, and MD + resveratrol groups. All participants were placed on the MD for 8 weeks. The MD + curcumin group also received 1600 mg/day of curcumin supplementation, whereas the MD + resveratrol group received 500 mg/day of resveratrol supplementation for 8 weeks. Anthropometric measurements, Truelove-Witts Index, Short Form-36, Inflammatory Bowel Disease Questionnaire, Mediterranean Diet Adherence Scale (MEDAS), and laboratory tests were performed at baseline and postintervention. Within-group comparisons showed that MD, MD + curcumin, and MD + resveratrol interventions were effective
Wong RH, Thaung Zaw JJ, Xian CJ, Howe PR · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
Resveratrol, a naturally occurring polyphenol in red grapes and berries, can act as a phytoestrogen. It has been shown to improve both systemic and cerebral circulatory functions, possibly through activation of endothelial estrogen receptors. in vitro and in vivo studies in rodent models also indicate a bone-protective role for resveratrol, particularly in ovariectomized rat models that mimic postmenopausal osteoporosis caused by estrogen deficiency. Hypothesizing a circulatory benefit of resveratrol in bone tissue, we investigated whether resveratrol supplementation could improve bone health in postmenopausal women. The Resveratrol for Healthy Aging in Women (RESHAW) trial was a 24-month randomized, double-blind, placebo-controlled, two-period crossover intervention conducted to evaluate the effects of resveratrol (75 mg twice daily) on cognition, cerebrovascular function, bone health, cardiometabolic markers, and well-being in postmenopausal women. After 12 months of su
Randomized TrialPubMedHigh Quality
Observational Studies(6)
Cohort, case-control, and cross-sectional human studies.
Ushida T, Tano S, Matsuo S, Fuma K, Imai K, Kajiyama H · Hypertension research : official journal of the Japanese Society of Hypertension · 2025
Preeclampsia (PE) is a common pregnancy complication characterized by hypertension, proteinuria, and end-organ dysfunction. However, to date, no effective treatment has been established other than iatrogenic delivery, and the importance of prevention as an alternative approach to addressing PE has been emphasized. There is growing evidence on the effectiveness of pharmacological and non-pharmacological prophylaxis in preventing PE. In this review, we focused on dietary supplements as non-pharmacological prophylaxis for PE. Calcium is a well-documented supplement for the prevention of PE. Daily 500 mg calcium supplementation can roughly halve the risk of PE in settings where calcium intake is low, including in Japan. According to recent systematic reviews and network meta-analyses, current evidence on the efficacy of vitamin D supplementation is inconsistent. Although vitamin D is a candidate for the prevention of PE, future large-scale randomized control trials are necessary to
Alotaibi G, Alkhammash A · European journal of pharmacology · 2025
The endoplasmic reticulum (ER) plays a fundamental role in maintaining cellular homeostasis by ensuring proper protein folding, lipid metabolism, and calcium regulation. However, disruptions to ER function, known as ER stress, activate the unfolded protein response (UPR) to restore balance. Chronic or unresolved ER stress contributes to metabolic dysfunctions, including insulin resistance, non-alcoholic fatty liver disease (NAFLD), and neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Recent studies have also highlighted the importance of mitochondria-ER contact sites (MERCs) and ER-associated inflammation in disease progression. This review explores the current pharmacological landscape targeting ER stress, focusing on therapeutic strategies for rare metabolic and neurodegenerative diseases. It examines small molecules such as tauroursodeoxycholic acid (TUDCA) and 4-phenylbutyric acid (4-PBA), repurposed drugs like 17-AAG (17-N-allylamino-17demethoxygeld
Hipólito-Reis M, Neto AC, Neves D · Phytotherapy research : PTR · 2022
Endometriosis, a gynecological disease that affects reproductive age women is difficultly controlled in the long term by currently available treatments, prompting patients to adopt self-controlled interventions including dietary changes. The aim of this review is to provide evidence of how curcumin, quercetin, and resveratrol can act as natural interventions to control endometriosis. The review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A comprehensive search was carried out in PubMed, Scopus, and Web of Science to gather together all the articles that study the specific actions of curcumin, resveratrol, or quercetin in endometriosis pathophysiology. All types of study designs including experimental data were considered. Thirty articles, including a clinical trial, were included. For the assessment of the quality of the selected studies that globally have "good quality", the GRADE (Grading of Recommendations Assessment, Development
Observational StudyPubMedLow Quality
Clinical Trial Registries(3)
Registered ongoing or completed trials (ClinicalTrials.gov).
1. To measure the ability of trans-resveratrol to influence the development of chronic heart failure (CHF) in women in the early postmenopausal period (1-4 years) with hypertension (HTN) and reduced bone mineral density (BMD).
2. To evaluate the safety of long-term use of trans-resveratrol in an amount of 500 mg per day.
3. To develop modern measures to influence the development of CHF in women of this group
The purpose of this study is to determine if Resveratrol, a nutritional supplement, shows a beneficial effect in the cellular function of normal liver cells and diseased liver cells (cancer cells) in samples of liver tissue taken during elective liver surgery. Outcomes based on 3 measures will test the hypothesis that Resveratrol when used as a nutritional supplement will 1)improve metabolic function in liver cells, 2)reduce cellular growth and proliferation of cancer cells, 3)decrease inflammation in the liver.
The objective of this Interventional case-control clinical study is to evaluate the effectiveness of physiotherapy combined with the administration of Alpha Lipoic Acid, L-acetylcarnitine, Resvelatrol, Vit D3 in the treatment of sciatica due to herniated disc in young patients.
The main questions we intend to answer are:
* Is this combined treatment more effective in reducing pain?
* Is the combined treatment useful for improving postural alterations, reducing the intake of painkillers and the number of days of absence from work and improving the quality of life?
Clinical TrialClinicalTrials.govModerate Quality
Limitations: Existing human trials often suffer from small sample sizes, heterogeneity in doses and formulations, and varied outcome measures. Further limitations include a lack of long-term studies to assess sustained effects and potential for publication bias. Many proposed mechanisms are derived from in vitro or animal models, which may not translate directly to human physiology.
This page is educational. Statements use phrases like "may support" and "has been studied for"because no remedy here is approved to cure, treat, or reverse any condition. Discussion happens on the ailment pages — community statistics here are derived from those reports. Always consult a qualified clinician.
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