A pungent root that has been studied for nausea and digestive comfort.
Ginger (Zingiber officinale) is a flowering plant whose rhizome is widely used as a spice and traditional medicine. It is commonly utilized for its potential to alleviate nausea and indigestion, and it is also studied for its anti-inflammatory properties. People typically consume ginger fresh, dried, powdered, or as an extract in teas, foods, and supplements.
Quick answer
What it is: Ginger (Zingiber officinale) is a flowering plant whose rhizome is widely used as a spice and traditional medicine.
Evidence for ginger's efficacy, particularly for nausea, includes numerous randomized controlled trials and meta-analyses. The consistent findings across multiple well-designed studies, especially concerning pregnancy-related nausea and chemotherapy-induced nausea, contribute to its strong evidence grade.
Last reviewed · Jun 2026
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Dietary protocols studied for the conditions this remedy is associated with.
Low-FODMAP Diet
A short-term elimination diet that restricts fermentable carbohydrates (FODMAPs) to identify food triggers in irritable bowel and other functional gut conditions.
FODMAPs (Fermentable Oligo-, Di-, Mono-saccharides And Polyols) are short-chain carbohydrates poorly absorbed in the small intestine. They draw water into the gut and are rapidly fermented by colonic bacteria, producing gas and bloating in sensitive people. The Monash University protocol uses a 2–6 week strict low-FODMAP elimination, followed by a structured reintroduction phase to identify personal triggers.
Foods to emphasize
Low-FODMAP vegetables: carrot, zucchini, spinach, bell pepper, cucumber, lettuce
High-FODMAP fruit: apple, pear, watermelon, mango, stone fruit
Wheat-based bread, pasta, and cereals (during the elimination phase)
Most legumes (chickpeas, kidney beans, lentils in large portions)
Lactose-containing dairy
Sugar alcohols (sorbitol, mannitol, xylitol)
High-fructose corn syrup
Key principles
Use the Monash FODMAP app to check serving sizes — many foods are dose-dependent
Do not stay in strict elimination longer than 8 weeks (microbiome impact)
Reintroduce one FODMAP subgroup at a time
Best done with a FODMAP-trained dietitian
Typical duration: 2–6 week strict elimination, then 6–8 weeks of structured reintroductions, then a long-term personalized diet.
Why it may help
Indigestion: Strong RCT evidence (Monash University) for symptom reduction in IBS and functional dyspepsia, with 60–80% of patients responding during the elimination phase.
Not intended as a long-term diet. The goal is to identify personal triggers and liberalize as much as possible.
Ketogenic Diet
Very-low-carbohydrate, high-fat eating pattern that shifts the body into ketosis, using ketones from fat as a primary fuel.
A classical ketogenic diet typically provides ~70–80% of calories from fat, ~15–20% from protein, and only ~5–10% (often 20–50 g/day) from carbohydrates. The metabolic shift to ketosis lowers blood glucose and insulin, raises ketone bodies (beta-hydroxybutyrate, acetoacetate), and is being studied for neurological and metabolic conditions. Variants include the Modified Atkins Diet (MAD), Medium-Chain Triglyceride (MCT) ketogenic diet, and the Low Glycemic Index Treatment (LGIT).
Foods to emphasize
Fatty fish (salmon, sardines, mackerel)
Pasture-raised eggs
Avocado and olives
Extra-virgin olive oil, coconut oil, MCT oil
Grass-fed meat and poultry
Full-fat dairy (butter, ghee, hard cheeses)
Nuts and seeds (macadamia, pecan, walnut, chia, flax)
Low-carb leafy greens and cruciferous vegetables
Bone broth and electrolyte-rich foods
Foods to avoid
Sugar and sweetened beverages
Grains and starches (bread, pasta, rice, cereal)
Most fruit (except small portions of berries)
Legumes and beans
Starchy vegetables (potatoes, corn, peas)
Low-fat or sweetened dairy
Vegetable seed oils (soybean, corn, sunflower) in excess
Most processed and packaged foods
Key principles
Carbohydrate intake usually 20–50 g net carbs per day
Adequate protein (~1.2–1.7 g/kg) — not high-protein
Most calories from whole-food fats
Track electrolytes (sodium, potassium, magnesium) to prevent "keto flu"
Best initiated with clinician guidance if on medications for diabetes, blood pressure, or seizures
Typical duration: Often 3–6 months minimum to assess response; medically supervised protocols (e.g. for epilepsy) may be maintained for years.
Why it may help
Headache: Ketogenic and modified Atkins diets have shown reductions in migraine frequency in several small clinical studies, likely via stabilizing neuronal excitability and reducing CGRP-related inflammation.
Ketogenic therapy is a medical intervention when used for seizure disorders or oncology — work with a clinician or registered dietitian experienced in ketogenic therapy. Not recommended in pregnancy, type 1 diabetes without supervision, pancreatitis, certain fatty-acid oxidation disorders, or active eating disorders.
Anti-Inflammatory Diet
A whole-foods pattern designed to lower chronic, low-grade inflammation by emphasizing omega-3s, polyphenols, fiber, and minimizing ultra-processed foods, sugar, and seed oils.
The anti-inflammatory diet is not a single protocol but a synthesis of the patterns most consistently linked to lower inflammatory markers (CRP, IL-6, TNF-alpha) in human studies — Mediterranean-style eating, oily fish, abundant polyphenols, and low intake of ultra-processed foods, refined sugar, industrial seed oils, and excessive alcohol.
Foods to emphasize
Fatty fish 2–3x/week (salmon, sardines, mackerel, herring)
Extra-virgin olive oil
Berries, cherries, and other deeply colored fruit
Dark leafy greens and cruciferous vegetables
Turmeric, ginger, and culinary herbs
Green tea
Nuts (especially walnuts) and seeds (flax, chia)
Legumes and whole grains
Dark chocolate (≥70% cocoa) in moderation
Foods to avoid
Sugar-sweetened beverages and refined sugar
Ultra-processed snacks and ready meals
Industrial seed oils used at high heat (soybean, corn, sunflower, cottonseed)
Processed and cured meats
Refined flour products
Excess alcohol
Key principles
Cook with olive oil, finish with extra-virgin olive oil
Aim for 25–35 g of fiber per day from whole foods
Eat the rainbow — color diversity ~ polyphenol diversity
Limit added sugar to <25 g/day
Typical duration: A long-term eating pattern.
Why it may help
Joint Pain: Reductions in CRP and IL-6 on anti-inflammatory patterns translate to less pain and stiffness in arthritis trials.
Safe and flexible. Can be combined with Mediterranean, vegetarian, or plant-forward patterns.
Vegan Diet
A fully plant-based eating pattern that excludes all animal products — meat, fish, dairy, eggs, and honey.
A whole-food vegan diet emphasizes vegetables, fruit, legumes, whole grains, nuts, and seeds. It has been associated with improvements in body weight, blood lipids, and glycemic control, and is being studied for autoimmune and inflammatory conditions. It requires deliberate planning for vitamin B12, vitamin D, omega-3 (EPA/DHA), iodine, iron, zinc, and (sometimes) calcium.
Nuts and seeds (especially walnuts, chia, flax, hemp)
Fortified plant milks and nutritional yeast
Algae-based EPA/DHA supplement
Vitamin B12 supplement (non-negotiable)
Foods to avoid
Refined grains and sugar as the bulk of meals
Heavily processed vegan junk foods
Coconut and palm oils in excess
Key principles
B12 supplementation is required, not optional
Include a reliable iodine source (iodized salt or seaweed in moderation)
Get vitamin D from sun and/or a supplement
Combine grains and legumes across the day for complete protein
Choose calcium-fortified plant milk if not eating leafy greens daily
Typical duration: A long-term eating pattern.
Why it may help
Joint Pain: Several RCTs report meaningful improvements in pain, swelling, and CRP in rheumatoid arthritis patients on whole-food vegan diets.
Vegan diets can be excellent or deficient — quality depends on planning. Pregnant, breastfeeding, and growing children on vegan diets should be followed by a registered dietitian.
Autoimmune Protocol (AIP)
A strict elimination version of paleo designed to calm autoimmune flares and identify food triggers through structured reintroduction.
The Autoimmune Protocol removes foods commonly implicated in immune activation and gut permeability — grains, legumes, dairy, eggs, nightshade vegetables, nuts, seeds, refined sugar, alcohol, and additives — for a 30–90 day elimination, followed by careful one-at-a-time reintroduction. It is most studied in Hashimoto's thyroiditis and inflammatory bowel disease.
Foods to emphasize
Quality meat, poultry, and seafood (especially wild-caught fatty fish)
Organ meats once or twice weekly
A wide variety of non-nightshade vegetables and leafy greens
Nuts and seeds (including seed-based spices like cumin, coriander)
Refined sugar and sweeteners
Alcohol
NSAIDs and food additives where possible
Key principles
Pair the elimination with sleep, stress management, and movement
Track symptoms in a journal during reintroductions
Reintroduce one food every 5–7 days and watch for symptom changes
Most people do NOT need to stay strict long-term — the goal is a personalized maintenance diet
Typical duration: 30–90 day strict elimination, then a structured staged reintroduction over weeks to months.
Why it may help
Joint Pain: Eliminates nightshades, gluten, and dairy — common reported triggers — to identify dietary contributors to inflammatory joint pain.
AIP is restrictive and best done with a practitioner familiar with the protocol, especially when active autoimmune disease is involved or in pregnancy/lactation.
Vegetarian Diet
A plant-based eating pattern that excludes meat, poultry, and fish but typically allows eggs and/or dairy.
Vegetarian diets range from lacto-ovo (includes eggs and dairy) to lacto (dairy only) and ovo (eggs only). Done well, they are associated with lower rates of cardiovascular disease, type 2 diabetes, and some cancers. Done poorly, they can be high in refined grains and low in key nutrients (B12, iron, omega-3s, zinc).
Foods to emphasize
Legumes (lentils, chickpeas, beans, tofu, tempeh)
Whole grains (oats, quinoa, brown rice, whole wheat)
Vegetables and fruit, daily and varied
Nuts and seeds (almonds, walnuts, chia, flax, hemp)
The carnivore diet is the most aggressive elimination diet — it removes every plant food (and therefore every fiber, lectin, oxalate, gluten, and FODMAP source) to isolate animal-food tolerance. Proponents use it primarily as a short-term diagnostic elimination to surface food triggers in autoimmune, gut, and inflammatory conditions. Long-term safety data is limited and observational.
Foods to emphasize
Ruminant meat (beef, lamb, bison) — emphasized for nutrient density
Pasture-raised eggs
Fatty fish (salmon, sardines)
Organ meats (liver, kidney) once or twice weekly
Bone broth and bone marrow
Animal fats (tallow, butter, ghee)
Salt to taste
Optional: aged hard cheeses, heavy cream
Foods to avoid
All grains, legumes, and seeds
All vegetables and fruit
Nuts and plant oils
Sugar and sweeteners
Most processed foods
Alcohol
Key principles
Eat to satiety — no calorie counting
Salt food liberally to maintain electrolytes
Prioritize fattier cuts over lean meats
Reintroduce foods one at a time after the elimination window to identify triggers
Best tracked with a clinician given the radical nature of the change
Typical duration: Typically run as a 30–90 day elimination, then food reintroductions one at a time.
Why it may help
Joint Pain: Used as an elimination diet to surface plant-based food triggers (nightshades, lectins) reported by some people to drive joint pain. No clinical trials.
Long-term effects on cardiovascular markers, bone health, and the gut microbiome are not well established. Avoid in chronic kidney disease, gout flares, or active eating disorders without medical supervision.
Linked nutrient deficiencies
Vitamin and mineral deficiencies commonly associated with the conditions this remedy may support.
Omega-3 Fatty Acids (EPA/DHA)
Essential fatty acid
Anti-inflammatory lipids critical for brain, joint, and skin health.
Deficiency is common in vegetarians/vegans, older adults, and those on PPIs or metformin. Strongly implicated in neurological symptoms (MS-like presentations), fatigue, anxiety, and cognitive decline.
An estimated 50% of adults consume below the EAR. Low magnesium is linked to insomnia, anxiety, migraines, muscle tension, and poor blood sugar regulation.
Common symptoms
Muscle cramps or twitches
Poor sleep
Anxiety, irritability
Headaches/migraines
Constipation
Food sources
Pumpkin seeds
Dark leafy greens
Almonds and cashews
Dark chocolate (85%+)
Black beans
Avocado
Lab markers to discuss
RBC magnesium (more sensitive than serum)
Serum magnesium
Reference intake: 310–420 mg/day RDA depending on age and sex.
Supplementation notes: Glycinate for sleep/anxiety, citrate for constipation, threonate for cognitive/brain effects. Avoid magnesium oxide (poorly absorbed).
Why it matters here
Headache: Magnesium prophylaxis reduces migraine frequency; AAN/AHS gives it Level B.
Indigestion: Helps motility and is depleted by chronic PPI/antacid use.
Joint Pain: Supports muscle relaxation and reduces secondary pain.
Vitamin D
Fat-soluble vitamin
Hormone-like vitamin central to immune function, mood, bone, and thyroid health.
Low vitamin D status is one of the most widespread deficiencies globally and has been linked to autoimmune disease activity (Hashimoto's, MS), mood disorders, recurrent infections, and poor skin barrier function.
Common symptoms
Fatigue
Low mood
Frequent infections
Bone or muscle aches
Hair thinning
Food sources
Fatty fish (salmon, sardines)
Egg yolks
Cod liver oil
UV-exposed mushrooms
Fortified dairy
Lab markers to discuss
25-hydroxyvitamin D (target 40–60 ng/mL per most functional ranges)
Reference intake: Adults 600–800 IU/day RDA; functional medicine often targets 2,000–5,000 IU/day with monitoring.
Supplementation notes: Take with a fat-containing meal. Pair with vitamin K2 (MK-7) when supplementing higher doses long-term.
Why it matters here
Sinus Infections: Low vitamin D is associated with chronic rhinosinusitis.
Joint Pain: Deficiency is associated with chronic widespread pain and osteoarthritis progression.
Common Cold/Flu: Low vitamin D increases respiratory infection risk; supplementation reduces incidence.
Zinc
Trace mineral
Required for immune function, wound healing, skin integrity, and thyroid hormone synthesis.
Low zinc is linked to recurrent infections, acne, slow wound healing, leaky gut, and impaired taste/smell. Often deficient in vegetarians and those with gut malabsorption.
Common symptoms
Frequent colds/infections
Acne or slow-healing skin
Loss of taste or smell
Hair loss
White spots on nails
Food sources
Oysters
Beef and lamb
Pumpkin seeds
Cashews
Lentils and chickpeas
Lab markers to discuss
Plasma or serum zinc
Zinc/copper ratio
Reference intake: 8–11 mg/day RDA.
Supplementation notes: Take away from iron and calcium. Long-term high-dose zinc depletes copper — pair with ~1 mg copper if dosing >30 mg/day.
Why it matters here
Common Cold/Flu: Lozenges within 24h of symptom onset shorten cold duration.
Sinus Infections: Supports epithelial repair and antimicrobial defense.
Indigestion: Needed for HCl production; low zinc perpetuates hypochlorhydria.
Vitamin B6 (Pyridoxine)
B-vitamin
Cofactor for neurotransmitter synthesis (serotonin, GABA, dopamine) and homocysteine metabolism.
Ginger appears to exert its effects through active compounds like gingerols and shogaols, which may influence neurotransmitter systems and inflammatory pathways in the body.
How it works in more detail
The primary active compounds, gingerols and shogaols, have been studied for their interaction with serotonin (5-HT3) receptors, particularly in the gut, which is thought to be relevant for anti-nausea effects. These compounds also appear to modulate inflammatory pathways, potentially by inhibiting prostaglandin and leukotriene synthesis, similar to some non-steroidal anti-inflammatory drugs (NSAIDs). Additionally, preclinical studies suggest ginger may possess antioxidant properties.
How to use
Always consult a qualified clinician.
Editorial guidance
Suggested dosage
Commonly studied dosages for nausea range from 250 mg to 1000 mg of powdered ginger daily, often divided into multiple doses. Product labels typically suggest dosages between 500 mg and 2000 mg per day for general well-being. It is important to note that individual needs may vary, and consulting a healthcare professional is advisable before initiating supplementation.
Research dosage range
250-1500 mg/day of dried ginger powder or extract
Typical onset
For acute conditions like nausea, effects may be reported within 30 minutes to a few hours after consumption. For sustained benefits relating to inflammation or digestive support, consistent daily use over several weeks may be required.
For quality, look for products standardized to a certain percentage of gingerols and shogaols, which are the main active compounds. Third-party testing for purity and contaminants is also a good indicator of quality. Organic certification or sourcing from reputable regions known for ginger cultivation may also be considered.
Medication interactions
Anticoagulants (blood thinners)
Antiplatelet drugs
Diabetes medications
Blood pressure medications
Avoid if
Bleeding disorders (potential for increased bleeding risk)
Gallstones (potential for increased bile flow)
Community tips
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Suggested dosage
Commonly studied dosages for nausea range from 250 mg to 1000 mg of powdered ginger daily, often divided into multiple doses. Product labels typically suggest dosages between 500 mg and 2000 mg per day for general well-being. It is important to note that individual needs may vary, and consulting a healthcare professional is advisable before initiating supplementation.
General guidance — discuss specifics with a clinician.
Active medicinal compounds
Gingerol, shogaol, zingerone.
Nutritional contents
Source of manganese, vitamin B6, potassium; minimal calories.
Traditional use
Traditional use suggests ginger has been used in Ayurveda and Traditional Chinese Medicine for digestion and motion sickness.
Safety
Safety warnings
High doses may cause heartburn. Caution with bleeding disorders.
Avoid if
Bleeding disorders (potential for increased bleeding risk)
Gallstones (potential for increased bile flow)
Medication interactions
Anticoagulants (blood thinners)
Antiplatelet drugs
Diabetes medications
Blood pressure medications
Reported side effects
Heartburn
Diarrhea
Stomach upset
General guidance — discuss specifics with a clinician.
Evidence ecosystem
Scientific literature, clinical guidance, government sources, ongoing research, traditional use, and lived experience — grouped by source type and quality.
Overall grade (A)
Evidence for ginger's efficacy, particularly for nausea, includes numerous randomized controlled trials and meta-analyses. The consistent findings across multiple well-designed studies, especially concerning pregnancy-related nausea and chemotherapy-induced nausea, contribute to its strong evidence grade.
Mathieu S, Soubrier M, Peirs C, Monfoulet LE, Boirie Y, Tournadre A · Nutrients · 2022 · n=166
Conflicting evidence exists concerning the effects of nutrient intake in osteoarthritis (OA). A systematic literature review and meta-analysis were performed using PubMed, EMBASE, and Cochrane Library up to November 2021 to assess the effects of nutrients on pain, stiffness, function, quality of life, and inflammation markers. We obtained 52 references including 50 on knee OA. Twelve studies compared 724 curcumin patients and 714 controls. Using the standardized mean difference, improvement was significant with regard to pain and function in the curcumin group compared to placebo, but not with active treatment (i.e., nonsteroidal anti-inflammatory drugs, chondroitin, or paracetamol). Three studies assessed the effects of ginger on OA symptoms in 166 patients compared to 164 placebo controls. Pain was the only clinical parameter that significantly decreased. Vitamin D supplementation caused a significant decrease in pain and function. Omega-3 and vitamin E caused no changes in OA parame
Maharlouei N, Tabrizi R, Lankarani KB, Rezaianzadeh A, Akbari M, Kolahdooz F · Critical reviews in food science and nutrition · 2019 · n=473
This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to summarize the effect of ginger intake on weight loss, glycemic control and lipid profiles among overweight and obese subjects. We searched the following databases through November 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as Standardized Mean Difference (SMD) with 95% Confidence Intervals (95% CI). Heterogeneity between studies was assessed by the Cochran Q statistic and I-squared tests (I2). Overall, 14 studies were included in the meta-analyses. Fourteen RCTs with 473 subjects were included in our meta-analysis. The results indicated that the supplementation with ginger significantly decreased body weight (BW) (SMD -0.66; 95% CI, -1.31, -0.01; P = 0.04), waist-
Baek HI, Shen L, Ha KC, Park YK, Kim CS, Kwon JE · Food & function · 2024 · n=100
The purpose of this study was to evaluate the efficacy and safety of steamed ginger extract (GGE03) in subjects with mild knee osteoarthritis (OA). In total, 100 subjects were randomly assigned (1 : 1) to the GGE03 (0.48 g day-1 as GGE03) or placebo (0 g day-1 as GGE03) group and administered 1.6 g of the product for 12 weeks. Biomarkers were measured before and after intervention. At the efficacy endpoint, pain visual analog scale (VAS) Korean-Western Ontario and McMaster University Osteoarthritis Index (K-WOMAC; total scores, sub-scores) and patient global assessment (PGA) were found to be decreased in a statistically significantly manner in the GGE03 group compared to the placebo group. No significant changes were observed in any safety endpoint. These results suggest that GGE03 intake is useful as a functional food because it has beneficial effects in terms of improving joint pain as well as managing or preventing knee OA without side effects.
Martins LB, Rodrigues AMDS, Rodrigues DF, Dos Santos LC, Teixeira AL, Ferreira AVM · Cephalalgia : an international journal of headache · 2019
Previous studies have demonstrated the analgesic effects of ginger in different conditions, but evidence about its efficacy in migraine treatment is scarce.
This study aimed to evaluate the potential of ginger to improve acute migraine as an add-on strategy to standard treatment.
A double-blind placebo-controlled randomized clinical trial in the emergency room of a general hospital was conducted. Patients who sought medical care at the time of migraine attack were enrolled in this study. Only adults with episodic migraine (one to six migraine attacks per month) with or without aura were included. Sixty participants were randomized into two groups in which they received 400 mg of ginger extract (5% active ingredient) or placebo (cellulose), in addition to an intravenous drug (100 mg of ketoprofen) to treat the migraine attack. Patients filled a headache diary before, 0.5 h, 1 h, 1.5 h and 2 h after the medication. Pain severity, functional sta
Maghbooli M, Golipour F, Moghimi Esfandabadi A, Yousefi M · Phytotherapy research : PTR · 2014 · n=100
Frequency and torment caused by migraines direct patients toward a variety of remedies. Few studies to date have proposed ginger derivates for migraine relief. This study aims to evaluate the efficacy of ginger in the ablation of common migraine attack in comparison to sumatriptan therapy. In this double-blinded randomized clinical trial, 100 patients who had acute migraine without aura were randomly allocated to receive either ginger powder or sumatriptan. Time of headache onset, its severity, time interval from headache beginning to taking drug and patient self-estimation about response for five subsequent migraine attacks were recorded by patients. Patients(,) satisfaction from treatment efficacy and their willingness to continue it was also evaluated after 1 month following intervention. Two hours after using either drug, mean headaches severity decreased significantly. Efficacy of ginger powder and sumatriptan was similar. Clinical adverse effects of ginger powder were less
Randomized TrialPubMedHigh Quality
Observational Studies(2)
Cohort, case-control, and cross-sectional human studies.
This randomized controlled trial investigated the clinical effects of ginger in humans. Researchers observed various health markers to assess the potential impact of ginger supplementation as described in Phytotherapy Research.
Rondanelli M, Fossari F, Vecchio V, Gasparri C, Peroni G, Spadaccini D · Phytotherapy research : PTR · 2020
Ginger has a pain-reducing effect and it can modulate pain through various mechanisms: inhibition of prostaglandins via the COX and LOX-pathways, antioxidant activity, inibition of the transcription factor nf-kB, or acting as agonist of vanilloid nociceptor. This narrative review summarizes the last 10-year of randomized controlled trials (RCTs), in which ginger was traditionally used as a pain reliever for dysmenorrhea, delayed onset muscle soreness (DOMS), osteoarthritis (AO), chronic low back pain (CLBP), and migraine. Regarding dysmenorrhea, six eligible studies suggest a promising effect of oral ginger. As concerned with DOMS, the four eligible RCTs suggested a reduction of inflammation after oral and topical ginger administration. Regarding knee AO, nine RCTs agree in stating that oral and topical use of ginger seems to be effective against pain, while other did not find significant differences. One RCT considered the use of ginger in migraine and suggested its beneficial activit
Observational StudyPubMedLow Quality
Animal Studies(3)
Preclinical animal research — not a substitute for human evidence.
Mabrouk DM, El Makawy AI, Ahmed KA, Ramadan MF, Ibrahim FM · Environmental science and pollution research international · 2022
Topiramate has multiple pharmacological mechanisms that are efficient in treating epilepsy and migraine. Ginger has been established to have gingerols and shogaols that cause migraine relief. Moreover, Topiramate has many off-label uses. Thus, it was necessary to explore the possible neurotoxicity of Topiramate and the role of ginger oil in attenuating the Topiramate neurotoxicity. Male albino mice were orally gavaged with Topiramate, ginger oil (400 mg/kg), and Topiramate plus ginger oil with the same pattern for 28 days. Oxidative stress markers, acetylcholinesterase (AchE), gamma-aminobutyric acid (GABA), and tumor necrosis factor-alpha (TNF-α) were examined. Histopathological examination, immunohistochemical glial fibrillary acidic protein (GFAP), and Bax expression analysis were detected. The GABAAR subunits, Gabra1, Gabra3, and Gabra5 expression, were assessed by RT-qPCR. The investigation showed that Topiramate raised oxidative stress markers levels, neurotransmi
Nguyen S, Rajfer J, Shaheen M · Translational andrology and urology · 2018
The earliest sign of an ongoing change in a man's erectile function (EF) is the increase in his refractory period. This is due to the onset of an aging related apoptosis of the corporal smooth muscle cells (CSMC) as a result of oxidative stress (ROS) within the CSMC itself. In response, the CSMC begin to upregulate the inducible nitric oxide synthase (iNOS) enzyme presumably to achieve high levels of nitric oxide (NO) used to combat ROS. Treatment of aged rats for 2 months with the nutraceutical Revactin®, known to stimulate the iNOS-NO-cGMP pathway in CSMC, resulted in (I) an increase in CSMC content with a decrease in corporal fibrosis, (II) decrease in systemic ROS, and (III) improvement in EF. To determine whether Revactin® could be used in the clinical setting, a pilot safety study was conducted.
Fifty-four middle aged men (mean age 57.8±10.7; range, 33-77 years) were recruited for this safety study. Patients were given Revactin® twice daily (total daily dose
Slavin M, Bourguignon J, Jackson K, Orciga MA · Nutrients · 2016
Calcitonin gene-related peptide (CGRP) is a pivotal messenger in the inflammatory process in migraine. Limited evidence indicates that diet impacts circulating levels of CGRP, suggesting that certain elements in the diet may influence migraine outcomes. Interruption of calcium signaling, a mechanism which can trigger CGRP release, has been suggested as one potential route by which exogenous food substances may impact CGRP secretion. The objective of this study was to investigate the effects of foods and a dietary supplement on two migraine-related mechanisms in vitro: CGRP secretion from neuroendocrine CA77 cells, and calcium uptake by differentiated PC12 cells. Ginger and grape pomace extracts were selected for their anecdotal connections to reducing or promoting migraine. S-petasin was selected as a suspected active constituent of butterbur extract, the migraine prophylactic dietary supplement. Results showed a statistically significant decrease in stimulated CGRP secretion from CA77
Animal StudyPubMedLow Quality
Clinical Trial Registries(6)
Registered ongoing or completed trials (ClinicalTrials.gov).
The aim of this clinical study is to investigate the effect of a ginger formulation as a dietary supplement on gastrointestinal complaints in healthy adults.
The effect of this formula will be compared to a placebo after 8 weeks of consumption.
The main objective of the study was to evaluate ginger efficacy as an adjuvant to ketoprofen for the treatment of headache and other symptoms related with migraine attacks.
Clinical TrialClinicalTrials.govModerate Quality
Limitations: While robust for certain applications, some studies exhibit heterogeneity in study populations and ginger preparations used, making direct comparisons challenging. There is also a need for more large-scale, long-term trials to fully understand all potential benefits and risks. Research into other applications, such as pain management, has more limited and sometimes conflicting results.
Health Voice Perspectives
Independent of evidence grade
Approved mentions from health educators, physicians, and researchers across podcasts, videos, and articles. Educational context only — does not influence the scientific evidence rating above.
Explained ginger's prokinetic and anti-inflammatory effects on the gut.
YouTubeGinger for InflammationView source ·3/14/2026
This page is educational. Statements use phrases like "may support" and "has been studied for"because no remedy here is approved to cure, treat, or reverse any condition. Discussion happens on the ailment pages — community statistics here are derived from those reports. Always consult a qualified clinician.
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