Parkinson's disease is a progressive neurological disorder that primarily affects movement, characterized by tremors, rigidity, slow movement, and impaired balance, resulting from the loss of dopamine-producing neurons in the brain.
Ranked by community outcomes, then evidence grade, Health Voice mentions, and recency.
Why it may help Parkinson's Disease: Vitamin D3 may modulate neuroinflammation and oxidative stress, which are implicated in the progression of Parkinson's disease, thereby potentially supporting neuronal health and function.
Vitamin D, a steroid hormone, is crucial for bone health and immune regulation, with growing evidence suggesting its involvement in thyroid disorders and other autoimmune conditions.
Why it may help Parkinson's Disease: Mucuna Pruriens contains L-DOPA, a direct precursor to dopamine, which can cross the blood-brain barrier and replenish dopamine levels, thereby alleviating motor symptoms in Parkinson's disease.
Why it may help Parkinson's Disease: Creatine monohydrate may support cellular energy production in the brain by increasing phosphocreatine stores, potentially protecting dopaminergic neurons from energy depletion and oxidative stress in Parkinson's disease.
Brain-penetrating magnesium for cognition, memory, and sleep.
Why it may help Parkinson's Disease: Green tea extract, rich in EGCG, may exert neuroprotective effects by reducing oxidative stress and inflammation, thereby potentially safeguarding dopaminergic neurons from degeneration in Parkinson's disease.
Why it may help Parkinson's Disease: Coenzyme Q10 (Ubiquinol) supports mitochondrial function and acts as an antioxidant, which may help protect dopaminergic neurons from oxidative damage and improve energy metabolism in Parkinson's disease.
Why it may help Parkinson's Disease: N-Acetyl Cysteine (NAC) replenishes glutathione, a crucial antioxidant, which may help reduce oxidative stress and protect dopaminergic neurons from damage in Parkinson's disease.
Why it may help Parkinson's Disease: Omega-3 fatty acids, particularly DHA and EPA, possess anti-inflammatory and neuroprotective properties that may help reduce neuroinflammation and oxidative stress, potentially slowing neuronal degeneration in Parkinson's disease.
Why it may help Parkinson's Disease: Ginkgo biloba may improve cognitive function in Parkinson's disease by enhancing cerebral blood flow and providing antioxidant protection against oxidative stress in the brain.
Why it may help Parkinson's Disease: Green tea's catechins, particularly EGCG, possess antioxidant and anti-inflammatory properties that may protect dopaminergic neurons from damage and reduce neuroinflammation associated with Parkinson's disease.
Why it may help Parkinson's Disease: Alpha-lipoic acid may offer neuroprotection in Parkinson's disease by acting as a potent antioxidant, reducing oxidative stress and inflammation that contribute to dopaminergic neuron damage.
Why it may help Parkinson's Disease: Coenzyme Q10 supports mitochondrial function and acts as a potent antioxidant, which may help protect dopaminergic neurons from oxidative damage and improve energy metabolism in Parkinson's disease.
Why it may help Parkinson's Disease: Turmeric, specifically its active compound curcumin, may exert neuroprotective effects in Parkinson's disease by reducing oxidative stress and inflammation, which contribute to neuronal degeneration.
An adaptogenic herb that has been studied for stress, thyroid function, and energy.
Community outcomes
Self-reported by community members · not medical advice.
Self-reported community outcomes. Not medical advice. Requires at least three reports per remedy to surface.
Community outcome data is still being collected for this ailment.
Be the first to share your experience →As more members share outcomes, RemedyAtlas will show which remedies helped people with similar conditions, symptoms, goals, and lab patterns.
Structured experience reports from people managing this condition. Not medical advice.
You can share without an account — we'll send a one-time code to verify your email. Or sign in.
Loading posts…
Community Discussions
How global health authorities view Parkinson's Disease.
The Mayo Clinic acknowledges the role of exercise in managing Parkinson's symptoms and improving well-being. The National Institute of Neurological Disorders and Stroke (NINDS), part of the NIH, supports research into both conventional and complementary therapies for PD, noting that some complementary approaches like exercise may help with symptoms. The NCCIH (National Center for Complementary and Integrative Health) emphasizes the importance of discussing any complementary health approaches with a healthcare provider, especially due to potential interactions with conventional medications. While some natural remedies are being studied for their potential neuroprotective or symptomatic benefits, major health bodies generally emphasize that these should complement, not replace, conventional
Indexed studies for Parkinson's Disease, grouped by source type and quality.
Filter by source type
Pooled analyses across multiple human trials.
Yan R, Zheng X, Yin Y, Zhang J, Cui Y, Su D · Movement disorders : official journal of the Movement Disorder Society · 2025
Dyskinesia is a motor complication of Parkinson's disease (PD) posing therapeutic challenges. The optimal therapy for dyskinesia in PD has not been identified due to the lack of comprehensive evaluation of treatments. The aim was to compare the efficacy and safety of interventions for alleviating levodopa-induced dyskinesia in PD. We conducted a Bayesian network meta-analysis (NMA) by systematically searching PubMed, Web of Science, Embase, Cochrane Library, ClinicalTrials.gov, and EudraCT databases up to April 1, 2024. The primary efficacy outcome was the change in scores on dyskinesia rating scales from baseline. The study included 85 randomized controlled trials (RCT) involving 13,826 PD patients, comprising 39 interventions. Nine treatments were significantly more effective in reducing scores on dyskinesia rating scales than control (placebo, sham surgery, sham repetitive transcranial magnetic stimulation, or best medical treatment). Globus pallidus interna deep brain stimulatio
Interventions for preventing falls in older people in care facilities.
Dyer SM, Kwok WS, Suen J, Dawson R, Kneale D, Sutcliffe K · The Cochrane database of systematic reviews · 2025 · n=964
Falls in care facilities are common events, causing considerable morbidity and mortality for older people. This is an update of a review on interventions in care facilities and hospitals first published in 2010 and updated in 2012 and 2018 on interventions in care facilities and hospitals. This review has now been split into separate reviews for each setting. To assess the benefits and harms of interventions designed to reduce the incidence of falls in older people in care facilities. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, and two trial registers to 10 May 2024 and used reference checking, citation searching, and contact with authors to identify eligible trials and records. We included randomised controlled trials (RCTs) of any intervention for preventing falls in older people (aged over 65 years) in care facilities with any comparator. We excluded trials conducted in places of residence that do not provide residential heal
De Natale G, Qorri E, Todri J, Lena O · Medicina (Kaunas, Lithuania) · 2025 · n=518
Background and Objectives: Virtual reality (VR)-based interventions provide immersive and interactive environments that can enhance motor learning and deliver real-time feedback, offering potential advantages over conventional therapies. This systematic review evaluated the impact of non-immersive and immersive VR exergaming interventions versus conventional therapy on balance in Parkinson's disease (PD) through a detailed analysis of randomized controlled trials (RCTs). Materials and Methods: A comprehensive search was conducted across the PubMed, Lilacs, IBECS, CENTRAL, Web of Science (WOS), EBSCOHost, and SciELO databases. Article selection and duplicate removal were managed using Rayyan QCRI. The quality of the evidence was assessed using the GRADE system. Results: From an initial screening of 100 studies, 58 underwent title and abstract screening. After full-text evaluation, 11 RCTs met the inclusion criteria, involving 518 participants with PD (average age: 67.3 years; 67.95% men
Structured reviews of the full body of evidence (incl. Cochrane).
Wallin A, Franzén E, Studsgaard J, Hansen MB, Johansson S, Brincks JK · Parkinsonism & related disorders · 2025 · n=5335
Rehabilitation in individuals with Parkinson's disease (PD) often includes balance training, but knowledge about optimal training content remains limited. To describe the design, content, delivery, and reporting of balance training for individuals with PD, and furthermore, to map the systematic use and reporting of methods monitoring intensity in balance training interventions for individuals with PD. Six databases were searched. Interventions with at least 50 % of exercises challenging balance control were included. Balance training types (exergaming, multi-modal, sensory-motor integrated, and task-oriented) were categorized based on specific balance exercise components: motor (limits of stability, anticipatory motor strategies, reactive motor strategies, and control of dynamics), sensory (vestibular, visual, and somatosensory systems), and cognitive (dual-tasking in motor or cognitive activities). Training Frequency, Intensity, Time, Type, Volume, and Progression (FITT-VP prin
van Soest AP, Beers S, van de Rest O, de Groot LC · Advances in nutrition (Bethesda, Md.) · 2024
The Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet seems a promising approach to preserve brain function during aging. Previous systematic reviews have demonstrated benefits of the MIND diet for cognition and dementia, though an update is needed. Additionally, other outcomes relevant to brain aging have not been summarized. Therefore, this systematic review aims to give an up-to-date and complete overview on human studies that examined the MIND diet in relation to brain aging outcomes in adults aged ≥40 y. Ovid Medline, Web of Science core collection, and Scopus were searched up to July 25, 2023. Study quality was assessed using the Newcastle-Ottawa Scale and the Cochrane Risk-of-Bias tool. We included 40 articles, of which 32 were unique cohorts. Higher MIND diet adherence was protective of dementia in 7 of 10 cohorts. Additionally, positive associations were demonstrated in 3 of 4 cohorts for global cognition and 4 of
The role of nutrition on Parkinson's disease: a systematic review.
Bianchi VE, Rizzi L, Somaa F · Nutritional neuroscience · 2023
Parkinson's disease (PD) in elderly patients is the second most prevalent neurodegenerative disease. The pathogenesis of PD is associated with dopaminergic neuron degeneration of the substantia nigra in the basal ganglia, causing classic motor symptoms. Oxidative stress, mitochondrial dysfunction, and neuroinflammation have been identified as possible pathways in laboratory investigations. Nutrition, a potentially versatile factor from all environmental factors affecting PD, has received intense research scrutiny. A systematic search was conducted in the MEDLINE, EMBASE, and WEB OF SCIENCE databases from 2000 until the present. Only randomized clinical trials (RCTs), observational case-control studies, and follow-up studies were included. We retrieved fifty-two studies that met the inclusion criteria. Most selected studies investigated the effects of malnutrition and the Mediterranean diet (MeDiet) on PD incidence and progression. Other investigations contributed evidence on the crit
Recommendations from medical societies (NICE, AHA, ADA, ACG, Endocrine Society…).
Parkinson's disease in adults: diagnosis and management
NICE
This guideline covers diagnosing and managing Parkinson's disease in adults. It aims to improve the quality of life for people with Parkinson's by providing recommendations on accurate diagnosis and effective treatments.
Controlled human studies with random assignment.
Leta V, Zinzalias P, Batzu L, Mandal G, Staunton J, Jernstedt F · Movement disorders : official journal of the Movement Disorder Society · 2025 · n=74
Gut dysbiosis and gut-brain-axis involvement in people with Parkinson's disease (PwP) support the use of gut-microbiota-modulating interventions. Probiotics may help manage constipation in PwP; however, mechanisms underpinning additional beneficial properties are unknown. The aim was evaluating the effects of a probiotic (Lacticaseibacillus rhamnosus, Lactobacillus acidophilus, Lactiplantibacillus plantarum and Enterococcus faecium) on gut microbiota, inflammation, motor and non-motor symptoms (NMS) in PwP and constipation. In this multicenter, randomized, double-blind, placebo-controlled trial (NCT05146921), PwP and constipation were randomized (1:1) to receive either the probiotic (4.08 × 108 CFU/mL) or placebo orally (70 mL/day) for 12 weeks. The primary endpoint was the differential abundance of gut microbiota taxa between baseline and end-of-treatment in the active versus placebo group. Secondary/exploratory endpoints included changes in inflamma
Nutritional and dietary clinical trials for Parkinson's disease: a narrative review.
Giannakis A, Chondrogiorgi M, Konitsiotis S, Sidiropoulos C · Journal of neural transmission (Vienna, Austria : 1996) · 2025
This study aims to review clinical trials investigating dietary or nutritional interventions for Parkinson's Disease (PD) and identify potential research gaps. A PubMed search yielded 3378 results, and after applying inclusion and exclusion criteria, 38 studies were selected. Of these, 13 focused on interventions with potential neuroprotective effects against PD, 18 examined symptom improvement, and 7 explored their relationship to antiparkinsonian medication. Most studies were randomized controlled trials (RCTs) and demonstrated promising results. However, they were often limited by small sample sizes and short durations. Large-scale, double-blind, placebo-controlled RCTs are necessary to further investigate the effects of dietary and nutritional interventions in PD. Other nutrients with promising results in preclinical research should be further evaluated in clinical trials. Moreover, research should prioritize dietary pattern interventions, like the Mediterranean and ketogenic diets
Fiorenzato E, Zabberoni S, De Simone MS, Costa A, Tieri G, Taglieri S · Journal of the neurological sciences · 2025
Neurocognitive disturbances in Parkinson's disease (PD) are common and can impact several aspects of daily functioning and quality of life. This multicenter study evaluated the efficacy of a novel immersive virtual reality (iVR) cognitive training (CT) targeting executive functions (EF)-planning, shifting, and updating abilities-to improve prospective memory (PM) in PD patients with mild cognitive impairment (PD-MCI). Potential transfer effects were also examined in healthy older adults (HC). In this double-blind randomized controlled trial, 30 PD-MCI were randomized into a 4-week EF-training (PD-CT) or active placebo (PD-AP), delivered at home through a combined approach of telemedicine and iVR. Similarly, 30 age- and education-matched HC were assigned to the EF-training (HC-CT) or active placebo (HC-AP). The PD-CT group exhibited significant improvements in PM (in time-based and verbal-response tasks) and in EF, particularly in inhibition abilities (in the Stroop test), with effect
Cohort, case-control, and cross-sectional human studies.
Zhou H, Wang Z, Tan Z, Deng B, Yang W, Huang Z · EBioMedicine · 2026 · n=647
Neuro-related proteins are promising biomarkers and therapeutic targets for Parkinson's disease (PD), yet their specific roles remain uncertain. We conducted Mendelian randomisation by integrating protein quantitative trait loci with genome-wide association study data from 33,647 patients with PD and 449,056 controls for risk, 28,568 patients for age at onset (AAO), and 4093 patients for progression. Subsequent analyses included genetic colocalisation, protein-protein interaction, functional enrichment, tissue and cell-specific expression profiling, and druggability assessment. In an case-control study (30 patients with PD, 14 controls), plasma neuro-related proteins were measured using the Olink platform. 59 neuro-related proteins were associated with PD: 4 (CLEC1B, IL5RA, SNCG, CDH17) associated with risk, 7 with AAO, and 58 with progression. Colocalisation supported shared variants for TDGF1, PVR, and IL5RA with the progression. 47 proteins were evaluated as druggable targets. Pat
Contribution of Nutritional, Lifestyle, and Metabolic Risk Factors to Parkinson's Disease.
Veronese N, Nova A, Fazia T, Riggi E, Yang L, Piccio L · Movement disorders : official journal of the Movement Disorder Society · 2024 · n=17
Modifiable risk factors for Parkinson's disease (PD) are poorly known. The aim is to evaluate independent associations of different nutritional components, physical activity, and sedentary behavior and metabolic factors with the risk of PD. In this population-based prospective cohort study using the data of the United Kingdom Biobank (from 2006-2010), 502,017 men and women who were free from PD (International Classification of Diseases 10th edition; "G20") at baseline were included. We implemented a Cox proportion hazard's model to evaluate the associations of different levels of physical activity, sitting time, sleep habits, diet quality, alcohol and coffee consumption, smoking, and body mass index with PD risk, adjusting for several confounding variables. During a median follow-up of 12.8 years, lifestyle factors including vigorous physical activity (hazard ration [HR] = 0.84; 95% confidence interval [CI], 0.75-0.94), low-to-moderate sitting time (HR =&
Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment.
Salim S, Ahmad F, Banu A, Mohammad F · Journal of advanced research · 2023
Parkinson's disease (PD) is a disease of ⍺-synuclein aggregation-mediated dopaminergic neuronal loss in the substantia nigra pars compacta, which leads to motor and non-motor symptoms. Through the last two decades of research, there has been growing consensus that inflammation-mediated oxidative stress, mitochondrial dysfunction, and cytokine-induced toxicity are mainly involved in neuronal damage and loss associated with PD. However, it remains unclear how these mechanisms relate to sporadic PD, a more common form of PD. Both enteric and central nervous systems have been implicated in the pathogenesis of sporadic PD, thus highlighting the crosstalk between the gut and brain. of Review: In this review, we summarize how alterations in the gut microbiome can affect PD pathogenesis. We highlight various mechanisms increasing/decreasing the risk of PD development. Based on the previous supporting evidence, we suggest how early interventions could protect against PD development and
Public-health agencies: NCCIH, NIH, CDC, NHS.
NHS
This page provides comprehensive information about Parkinson's disease, including symptoms, causes, diagnosis, and treatment options available through the NHS.
Registered ongoing or completed trials (ClinicalTrials.gov).
n=20 · NCT06485986 · RECRUITING · RECRUITING
The goal of this experimental study with is to understand the underlying mechanisms behind the increase in impulsivity seen in some patients that undergo deep brain stimulation of the subthalamic nucleus for Parkinson's Disease. The main questions it aims to answer are: What are the distributed network effects of deep brain stimulation to the subthalamic nucleus? How does this correlate with increased impulsivity? Can alternative stimulation settings be used to minimize these? Participants will complete decision-making tasks whilst their deep brain stimulation devices are turned on and off with simultaneous magnetoencephalography recordings (a type of non-invasive brain scan that measures brain activity in real-time)
n=56 · NCT07264114 · ACTIVE_NOT_RECRUITING · ACTIVE_NOT_RECRUITING
This randomized, single-center, parallel-group superiority trial will evaluate the effect of an 8-week aquatic High-Intensity Interval Training (HIIT) program on balance, physical function, and sarcopenia-related outcomes in individuals with Parkinson's disease (PD). The intervention aims to deliver Tabata-style aquatic HIIT (3 sessions/week) in a therapeutic pool to determine adherence and preliminary efficacy compared with standard care (no structured exercise program).
A Phase 1 Study of Intranasal Reduced Glutathione in Parkinson's Disease
n=34 · NCT01398748 · COMPLETED · COMPLETED
Excessive free radical formation and depletion of the brain's primary antioxidant, glutathione, are established components of Parkinson's disease (PD) pathophysiology. While there is rationale for the therapeutic use of reduced glutathione (GSH) in PD, and even some preliminary evidence to suggest the use of GSH can lead to symptomatic improvement, obstacles surrounding currently employed delivery methods have hindered the clinical utility of this therapy. Intranasal GSH, (in)GSH, is a novel method of delivery for this popular CAM therapy in patients with PD, and bypasses the obstacles associated with other delivery methods. It has been used in clinical practice since 2005. The aim of this study is to evaluate safety, tolerability, and preliminary absorption data of (in)GSH in volunteers with PD in a Phase I single ascending dose escalation study.
Curated cross-source summaries (TRIP Database and similar).
Cochrane reviews on Parkinson's disease
Cochrane
Cochrane Library provides a collection of systematic reviews and meta-analyses investigating the effects of healthcare interventions for Parkinson's disease.
TRIP Database search results for Parkinson's Disease
TRIP Database
TRIP Database is a clinical search engine designed to allow users to quickly find high quality clinical evidence for Parkinson's Disease.
Conventional medical care for Parkinson's disease typically involves medications such as levodopa, dopamine agonists, MAO-B inhibitors, and COMT inhibitors to manage motor symptoms. Deep brain stimulation (DBS) surgery may be considered for some individuals. Physical, occupational, and speech therapy are also integral parts of conventional management. It is crucial to work closely with a neurologi
Latest News
Health Videos
This information is for educational purposes only and should not be considered medical advice. Parkinson's disease is a complex condition requiring professional medical diagnosis and management. Always consult with a qualified healthcare provider before making any decisions about your health or trea
Found something that helped your parkinson's disease?
Help others see what actually works.
Found something that helped your parkinson's disease?
Real-world results help others choose what's worth trying.