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Cinnamon

traditional spice with potential metabolic health applications

Evidence · Grade B
Meta-analysis availableSystematic review availableHuman trial evidenceTraditional useInteraction risk

Cinnamon is a popular spice and traditional remedy, historically used for various ailments, with emerging interest in its potential metabolic health benefits, though scientific evidence is still developing.

Cinnamon, derived from the bark of Cinnamomum trees, has been traditionally used for its medicinal properties and is gaining attention for its potential role in managing prediabetes. It is thought to improve insulin sensitivity and help regulate blood sugar levels, which are key aspects of prediabetes management. Various forms, such as cassia cinnamon and Ceylon cinnamon, are available, with different concentrations of active compounds.

Quick answer

What it is: Cinnamon, derived from the bark of Cinnamomum trees, has been traditionally used for its medicinal properties and is gaining attention for its potential role in managing prediabetes.

May support:Prediabetes, Insulin Resistance, Endometriosis, Obesity, Menstrual Cramps, Type 1 Diabetes, Type 2 Diabetes, PCOS

Evidence:Evidence · Grade B

Evidence Summary

Evidence · Grade B

The current evidence grade is conservative due to the absence of specific PubMed studies provided for this request. General knowledge suggests that much of the research on cinnamon's health benefits, particularly for conditions like diabetes and insulin resistance, comes from in vitro studies, animal models, and a limited number of human clinical trials, which often vary in methodology and quality. Therefore, strong, consistent evidence for many claims is still lacking.

Last reviewed · Jun 2026

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Why It Works

Cinnamon is believed to work through several mechanisms, including mimicking insulin, increasing glucose uptake by cells, and inhibiting enzymes that break down carbohydrates. Its active compounds, like cinnamaldehyde and various polyphenols, may improve insulin signaling pathways and reduce insulin resistance. This can lead to lower blood glucose levels after meals and improved glycemic control.

How it works in more detail

The potential mechanisms of action for cinnamon are complex and not fully elucidated. It is hypothesized that certain compounds in cinnamon, such as cinnamaldehyde and polyphenols, may play a role. These compounds are thought to interact with insulin signaling pathways, potentially by increasing insulin receptor sensitivity, stimulating glucose uptake by cells, or inhibiting enzymes involved in carbohydrate digestion. Additionally, cinnamon may exert antioxidant effects by scavenging free radicals and anti-inflammatory effects by modulating inflammatory pathways. Some research suggests it could also impact lipid metabolism and have antimicrobial properties.

How to use

Always consult a qualified clinician.

Editorial guidance

Suggested dosage
Typical dosages range from 1 to 6 grams per day, often divided into multiple doses. It can be consumed as a powder, extract, or in capsule form. Higher doses should be used with caution due to potential liver toxicity, especially with Cassia cinnamon.
Research dosage range
Research studies have explored a wide range of dosages, typically from 1 gram to 6 grams per day of powdered cinnamon or equivalent extracts. However, these dosages are not standardized and vary significantly across studies.
Typical onset
The onset of potential effects from cinnamon is not well-established and likely varies depending on the condition, dosage, and individual. For metabolic effects, changes may not be immediate and could
Typical forms
powder, sticks, extract, capsule, essential oil
Quality markers
When purchasing cinnamon, look for reputable brands. Distinguish between Ceylon cinnamon (true cinnamon), which has lower coumarin levels, and Cassia cinnamon, which is more common and higher in coumarin. Organic and sustainably sourced options are also preferable.
Medication interactions
  • Anticoagulants/Antiplatelets (blood thinners)
  • Diabetes medications (insulin, oral hypoglycemics)
  • Hepatotoxic drugs (medications that can harm the liver)
  • Medications metabolized by the liver (CYP450 enzymes)
Avoid if
  • Pregnant or breastfeeding (unless in culinary amounts)
  • Have liver disease or damage
  • Taking blood-thinning medications
  • Allergic to cinnamon or its components
  • Undergoing surgery (discontinue prior to procedure)

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Suggested dosage

Typical dosages range from 1 to 6 grams per day, often divided into multiple doses. It can be consumed as a powder, extract, or in capsule form. Higher doses should be used with caution due to potential liver toxicity, especially with Cassia cinnamon.

General guidance — discuss specifics with a clinician.

Active medicinal compounds

Cinnamaldehyde, Eugenol, Coumarin (higher in Cassia cinnamon), Polyphenols (e.g., proanthocyanidins), Cinnamic acid

Traditional use

Cinnamon has a rich history of traditional use across various cultures. In ancient Egypt, it was used for embalming and as a fragrance. In traditional Chinese medicine and Ayurveda, it has been employed for digestive issues, colds, menstrual problems, and to warm the body. It was also historically used as a preservative and to improve the flavor of foods and beverages.

Safety

Safety warnings

Cinnamon is generally considered safe for most people when consumed in moderate amounts. However, high doses of Cassia cinnamon, which contains coumarin, can potentially cause liver damage, especially in individuals with pre-existing liver conditions. Ceylon cinnamon has much lower coumarin levels and is considered safer for long-term use.

Avoid if

  • Pregnant or breastfeeding (unless in culinary amounts)
  • Have liver disease or damage
  • Taking blood-thinning medications
  • Allergic to cinnamon or its components
  • Undergoing surgery (discontinue prior to procedure)

Medication interactions

  • Anticoagulants/Antiplatelets (blood thinners)
  • Diabetes medications (insulin, oral hypoglycemics)
  • Hepatotoxic drugs (medications that can harm the liver)
  • Medications metabolized by the liver (CYP450 enzymes)

Reported side effects

  • Allergic reactions (skin irritation, mouth sores)
  • Liver damage (high doses of Cassia cinnamon due to coumarin)
  • Lowered blood sugar (especially with diabetes medications)
  • Heartburn or indigestion

General guidance — discuss specifics with a clinician.

Evidence ecosystem

Scientific literature, clinical guidance, government sources, ongoing research, traditional use, and lived experience — grouped by source type and quality.

Overall grade (B)

The current evidence grade is conservative due to the absence of specific PubMed studies provided for this request. General knowledge suggests that much of the research on cinnamon's health benefits, particularly for conditions like diabetes and insulin resistance, comes from in vitro studies, animal models, and a limited number of human clinical trials, which often vary in methodology and quality. Therefore, strong, consistent evidence for many claims is still lacking.

Filter by source type

Meta-Analyses(5)

Pooled analyses across multiple human trials.

Very High Quality
  • Effects of cinnamon supplementation on metabolic biomarkers in individuals with type 2 diabetes: a systematic review and meta-analysis.

    de Moura SL, Gomes BGR, Guilarducci MJ, Coelho OGL, Guimarães NS, Gomes JMG · Nutrition reviews · 2025 · n=3054

    The global prevalence of type 2 diabetes mellitus (DM2) has been rising significantly over the years. Recent studies have shown beneficial effects of cinnamon on metabolic biomarkers. The objective of this review was to assess the effect of cinnamon supplementation on metabolic biomarkers in patients with DM2. The Pubmed/MEDLINE, Cochrane CENTRAL, and Embase databases were searched up to November 10, 2022. A systematic search was performed for randomized controlled trials (RCTs) evaluating the effect of cinnamon supplementation on metabolic biomarkers, in adults and the elderly with DM2, and comparing the data for a cinnamon intervention group with that for a placebo group or a control group. The main exclusion criteria were studies (1) with other types of diabetes (ie, gestational diabetes or type 1 diabetes), (2) without cinnamon consumption, (3) that did not evaluate metabolic biomarkers, or (4) in vitro and animal studies. Two researchers independently screened 924 records, eval

    Meta-AnalysisPubMedVery High Quality
  • The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes mellitus: An updated systematic review and dose-response meta-analysis of randomized controlled trials.

    Moridpour AH, Kavyani Z, Khosravi S, Farmani E, Daneshvar M, Musazadeh V · Phytotherapy research : PTR · 2024

    Although many randomized controlled trials (RCTs) have revealed the benefits of cinnamon on type 2 diabetes mellitus (T2DM), the effects of cinnamon supplementation on glycemic control in patients with T2DM are inconclusive. Therefore, the aim of this meta-analysis of RCTs was to assess the effects of cinnamon supplementation in managing glycemic control in patients with T2DM. Scientific international databases including Scopus, Web of Sciences, PubMed, Embase, and the Cochrane Library were searched till December 2022. For net changes in glycemic control, standard mean differences (SMDs) were calculated using random-effects models. Findings from 24 RCTs revealed that cinnamon supplementation had a statistically significant reduction in fasting blood sugar (SMD: -1.32; 95% CI: -1.77, -0.87, p < 0.001), Homeostatic Model Assessment for Insulin Resistance (SMD: -1.32; 95% CI: -1.77, -0.87, p < 0.001), and hemoglobin A1C (SMD: -0.67; 95% CI: -1.18, -0.15,

    Meta-AnalysisPubMedVery High Quality
  • Chinese herbal medicine for the treatment of small intestinal bacterial overgrowth (SIBO): A protocol for systematic review and meta-analysis.

    Ren X, Di Z, Zhang Z, Fu B, Wang Y, Huang C · Medicine · 2020

    Chinese medicine has a unique theory and the Chinese herbal medicine treatment is based on the integral concepts and syndrome differentiation of the Traditional Chinese Medicine system. Although antibiotics remain the mainstay of SIBO treatment, various alternative or adjunctive therapies are available, including prokinetic agents, dietary interventions, probiotics, and herbal combinations. There is accumulating evidence demonstrating the antimicrobial properties of a growing number of herbs including garlic, black cumin, cloves, cinnamon, thyme, all-spices, bay leaves, mustard, and rosemary. This has prompted an interest in herbal therapy for the treatment of SIBO. Currently, there is no systematic review focusing on efficacy of CHM in the treatment of SIBO with PCOS, so our meta-analysis aims to comprehensively explore it. Meanwhile we will provide high-quality evidence to help patients, clinicians as well as health policymakers select better treatment strategy of PCOS. We will sear

    Meta-AnalysisPubMedVery High Quality

Systematic Reviews(1)

Structured reviews of the full body of evidence (incl. Cochrane).

Very High Quality
  • Polycystic ovaries and herbal remedies: A systematic review.

    Manouchehri A, Abbaszadeh S, Ahmadi M, Nejad FK, Bahmani M, Dastyar N · JBRA assisted reproduction · 2023 · n=15

    Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects one in every 15 women worldwide. This disorder is mainly characterized by increased levels of male hormones (androgens), acne, and hirsutism, and can lead to long-term insulin resistance, miscarriage, or even infertility in women. PCOS is a disorder that can be treated with natural and allopathic remedies that work against the PCOS mechanism. The present study reviews previous studies on the treatment of PCOS using natural drugs. The data in this study were collected from articles published in reputable databases including ScienceDirect, PubMed, Google Scholar, and SID in the field of medicinal plants from 1990 to 2021. A review of the literature showed that plants such as aloe vera and chamomile improve fertility by increasing the number of ovarian follicles. Besides, Vitex agnus-castus and octane reduce hirsutism by reducing testosterone and androgen levels. It was also shown that liquorice, ginseng, cinnamon, a

    Systematic ReviewPubMedVery High Quality

Observational Studies(3)

Cohort, case-control, and cross-sectional human studies.

Moderate Quality
  • Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome.

    Alesi S, Ee C, Moran LJ, Rao V, Mousa A · Advances in nutrition (Bethesda, Md.) · 2022

    Polycystic ovary syndrome (PCOS) affects 1 in 5 women of reproductive age, and is characterized by menstrual irregularities, clinical or biochemical hyperandrogenism, and the presence of polycystic ovary morphology. One of the recommended treatment strategies in the international evidence-based guidelines is lifestyle modification, which includes diet and exercise, with the aim of improving a range of health outcomes. The incurable nature of PCOS reinforces the importance of developing novel and innovative symptomatic relief strategies, which are currently the only available approaches for improving quality of life for these women. Women with PCOS tend to be nutrient deficient in many common vitamins and minerals, thought to be associated with the psychological (depression, anxiety, etc.) and physiological (insulin resistance, diabetes, infertility, etc.) sequelae of the condition. Nutrient supplementation and the integration of complementary medicine as adjuncts to traditional lifesty

    Observational StudyPubMedLow Quality
  • Cinnamon and health.

    Gruenwald J, Freder J, Armbruester N · Critical reviews in food science and nutrition · 2010

    Cinnamon has been used as a spice and as traditional herbal medicine for centuries. The available in vitro and animal in vivo evidence suggests that cinnamon has anti-inflammatory, antimicrobial, antioxidant, antitumor, cardiovascular, cholesterol-lowering, and immunomodulatory effects. In vitro studies have demonstrated that cinnamon may act as an insulin mimetic, to potentiate insulin activity or to stimulate cellular glucose metabolism. Furthermore, animal studies have demonstrated strong hypoglycemic properties. However, there are only very few well-controlled clinical studies, a fact that limits the conclusions that can be made about the potential health benefits of cinnamon for free-living humans. The use of cinnamon as an adjunct to the treatment of type 2 diabetes mellitus is the most promising area, but further research is needed before definitive recommendations can be made.

    Observational StudyPubMedLow Quality
  • Algorithm for complementary and alternative medicine practice and research in type 2 diabetes.

    Bradley R, Oberg EB, Calabrese C, Standish LJ · Journal of alternative and complementary medicine (New York, N.Y.) · 2007

    To develop a model to direct the prescription of nutritional and botanical medicines in the treatment of type 2 diabetes for both clinical and research purposes. Available literature on nutritional and botanical medicines was reviewed and categorized as follows: antioxidant/anti-inflammatory; insulin sensitizer; and beta-cell protectant/insulin secretagogue. Literature describing laboratory assessment for glycemic control, insulin resistance, and beta-cell reserve was also reviewed and a clinical decision tree was developed. Clinical algorithms were created to guide the use of nutritional and botanic medicines using validated laboratory measures of glycemic control, insulin sensitivity, and beta-cell reserve. Nutrient and botanic medicines with clinical trial research support include coenzyme Q10, carnitine, alpha-lipoic acid, N-acetylcysteine, vitamin D, vitamin C, vitamin E, chromium, vanadium, omega-3 fatty acids, cinnamon (Cinnamomum cassia), fenugreek (Trigonella foenum-graecum)

    Observational StudyPubMedLow Quality

Clinical Trial Registries(4)

Registered ongoing or completed trials (ClinicalTrials.gov).

Moderate Quality
  • A Pilot Study Investigating the Effects of a Nutritional Supplement on Physiological and Metabolic Markers in 38-55-year-old Females

    n=80 · NCT07615777 · NOT_YET_RECRUITING · NOT_YET_RECRUITING

    The goal of this clinical trial is to learn if a 12-week nutritional supplement can result in significant changes in the body composition of 38-55-year-old females. The main questions it aims to answer are: * Does a 12-week nutritional supplementation with myo-inositol, berberine, cinnamon, and chromium lead to significant changes in body composition (e.g. body mass index, body fat composition) in females aged 38-55 compared to placebo? * Does a 12-week nutritional supplementation with myo-inositol, berberine, cinnamon, and chromium lead to significant changes in small molecules (metabolites) in plasma and urine, menopause-related symptoms, and physical performance (e.g. grip strength) in females aged 38-55 compared to placebo? Researchers will compare the nutritional supplement to a placebo (a look-alike substance that contains no nutritional supplement) to see if the intervention works to change body composition in females aged 38-55. Participants will: * Sign a consent form before any procedures begin * Attend two visits to the clinical research facility at Southampton General Hospital over 12 weeks. * Fast before visit's and provide blood and urine samples at each visit * Undergo measurements at each visit, including waist and hip circumferences, grip and leg strength, and body composition. * Complete questionnaires about general health, menopause-related changes, alcohol consumption, physical activity, and diet. * Take 1 capsule 3 times a day at the onset of a meal (once in the morning, once at midday, and once in the evening) for the first 10 days. * Take 3 capsules 3 times a day at the onset of a meal (once in the morning, once at midday, and once in the evening) from day 11 to day 84. * Record supplement intake in a daily compliance diary during the study

    Clinical TrialClinicalTrials.govModerate Quality
  • Effect of Over-the-counter Dietary Supplements on Kidney Stone Risk

    n=45 · NCT02404701 · COMPLETED · COMPLETED

    The purpose of this study is to ascertain whether certain supplements promote excessive urinary oxalate excretion and increase the risk for calcium oxalate kidney stones. Supplements that enhance urinary oxalate excretion, as a result of their oxalate concentration or from some other mechanism (e.g., providing substrate for oxalate biosynthesis) will be identified by the investigators.

    Clinical TrialClinicalTrials.govModerate Quality
  • Supplements, Placebo, or Rosuvastatin Study

    n=203 · NCT04846231 · COMPLETED · COMPLETED

    A research study that is evaluating a low dose of an FDA approved statin medication in comparison to several commercially available over the counter dietary supplements which are marketed for cholesterol health. The study is comparing their effect on LDL cholesterol. LDL-cholesterol is low-density cholesterol and is sometimes referred to as "bad" cholesterol. Participants must live in Ohio and have a documented elevated LDL cholesterol level between 70-189mg/dL, must not currently be taking a statin or one of the dietary supplements included in the trial. Participants willing to discontinue a prohibited supplement for 4 weeks prior to enrollment will be allowed to participate. Trial participation is 4 weeks. Study medication will be provided at no charge. There will be 2 visits which include a lab draw at any Cleveland Clinic laboratory. Participants will be randomized (like a coin flip) to be in one of 8 possible groups: Rosuvastatin, Fish oil, Cinnamon, Garlic, Turmeric, Plant sterol, Red yeast rice, or placebo. The study will enroll 200 participants.

    Clinical TrialClinicalTrials.govModerate Quality

Limitations: A significant limitation is the lack of specific, high-quality human clinical trials with large sample sizes and standardized cinnamon preparations. Many studies are small, short-term, or use different forms and dosages of cinnamon, making comparisons difficult. There is also a need for more research to identify the most active compounds and their precise mechanisms of action in humans. The absence of provided studies means a direct assessment of specific evidence gaps cannot be made.

This page is educational. Statements use phrases like "may support" and "has been studied for"because no remedy here is approved to cure, treat, or reverse any condition. Discussion happens on the ailment pages — community statistics here are derived from those reports. Always consult a qualified clinician.

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