Endometriosis

The Effect of Hormonal Treatment on Ovarian Endometriomas: A Systematic Review and Meta-Analysis.

Thiel PS, Donders F, Kobylianskii A, Maheux-Lacroix S, Matelski J, Walsh C · Journal of minimally invasive gynecology · 2024 · n=888

To evaluate the effect of hormonal suppression of endometriosis on the size of endometriotic ovarian cysts. The authors searched MEDLINE, PubMed, Cochrane Central Register of Controlled Trials, Embase, and ClinicalTrials.gov from January 2012 to December 2022. We included studies of premenopausal women undergoing hormonal treatment of endometriosis for ≥3 months. The authors excluded studies involving surgical intervention in the follow-up period and those using hormones to prevent endometrioma recurrence after endometriosis surgery. Risk of bias was assessed with the Newcastle-Ottawa Scale and Cochrane Risk of Bias Tool. The protocol was registered in PROSPERO (CRD42022385612). The primary outcome was the mean change in endometrioma volume, expressed as a percentage, from baseline to at least 6 months. Secondary outcomes were the change in volume at 3 months and analyses by class of hormonal therapy. The authors included 16 studies (15 cohort studies, 1 randomized controlled

Understanding the impact of endometriosis on women's life: an integrative review of systematic reviews.

Maulenkul T, Kuandyk A, Makhadiyeva D, Dautova A, Terzic M, Oshibayeva A · BMC women's health · 2024

Endometriosis is a challenging chronic condition with a significant impact on women's well-being. This systematic review of systematic reviews aims to assess the evidence investigating the intricate interplay between endometriosis and quality of life (QoL). A systematic review was performed for English-language studies up to January 2022 to identify systematic reviews with and without meta-analysis analyzing quantitative or qualitative data The following databases were searched: Scopus, PubMed, Embase, Web of Science and Cochrane Central Register of Controlled Trials. Participants/population were women with endometriosis, and the outcomes included were all reported outcomes evaluating the impact of endometriosis on women's QoL (PROSPERO 2021 CRD42021289347). 15 systematic reviews were identified. 8 included meta-analysis: 4 explored the prevalence of mental health problems, and 1 analyzed, respectively, the overall impact of endometriosis, headache migraine, and sexual function. 7 ar

Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis: A systematic review and meta-analysis of randomized controlled trials.

Bayu P, Wibisono JJ · PloS one · 2024

The primary challenge encountered by individuals diagnosed with endometriosis is the experience of pain. Emerging research indicates that oxidative stress is implicated in the initiation of pain associated with endometriosis. Vitamins C and E are known for their antioxidative properties. The primary objective of this study is to assess the efficacy of antioxidant supplementation, consisting of these vitamins, in the management of pain associated with endometriosis. A comprehensive search was conducted on the ClinicalTrials.gov, Scopus, Europe PMC, and Medline databases up until August 23rd, 2023, utilizing a combination of relevant keywords. This review incorporates literature that examines the relationship between antioxidant supplementation and pain in endometriosis. We employed fixed-effect models to analyze the risk ratio (RR) and present the outcomes together with their corresponding 95% confidence intervals (CI). A total of five RCTs were incorporated. The results of our meta-a

[The importance of nutrition in the prevention of endometriosis - Systematic review].

Zaragoza-Martí A, Cabrera-González K, Martín-Manchado L, Moya-Yeste AM, Sánchez-Sansegundo M, Hurtado-Sánchez JA · Nutricion hospitalaria · 2024

Background and objective: endometriosis is a hormone-dependent disorder characterized by the presence of endometrial-like tissue in extrauterine sites, which can trigger a chronic inflammatory reaction. This disease mainly affects women of childbearing age and can have a negative impact on their physical, mental and social well-being. There are eating patterns considered as anti-inflammatory, such as the Mediterranean diet, which could help in the prevention and treatment of endometriosis. The objective of this review was to know the relationship between the consumption of different food groups and the prevention of endometriosis. Materials and methods: a systematic review was carried out following the PRISMA methodology. PubMed, Scopus, Cochrane Library and Web of Science databases were consulted. Studies published between 2013 and 2023 were selected, accessible in full text, written in English and Spanish and including a sample of women with endometriosis and/or healthy women, in add

The Role of Zinc in Selected Female Reproductive System Disorders.

Nasiadek M, Stragierowicz J, Klimczak M, Kilanowicz A · Nutrients · 2020

Zinc is an essential microelement that plays many important functions in the body. It is crucial for the regulation of cell growth, hormone release, immunological response and reproduction. This review focuses on its importance in the reproductive system of women of reproductive and postmenopausal ages, not including its well described role in pregnancy. Only recently, attention has been drawn to the potential role of zinc in polycystic ovary syndrome (PCOS), dysmenorrhea, or endometriosis. This review is mainly based on 36 randomized, controlled studies on reproductive, pre- and post-menopausal populations of women and on research trying to explain the potential impact of zinc and its supplementation in the etiology of selected female reproductive system disorders. In women with PCOS, zinc supplementation has a positive effect on many parameters, especially those related to insulin resistance and lipid balance. In primary dysmenorrhea, zinc supplementation before and during each menst

ESHRE guideline: Endometriosis

ESHRE · Strength: Varies by recommendation

This guideline provides evidence-based recommendations for the diagnosis and management of endometriosis, covering various aspects from medical to surgical treatments.

Management of Endometriosis

ACOG · Strength: Varies by recommendation

This ACOG Practice Bulletin provides clinical guidance for the comprehensive management of endometriosis, including diagnosis, medical management, and surgical approaches.

Endometriosis: diagnosis and management

NICE

This guideline covers the diagnosis and management of endometriosis in women aged 18 and over. It aims to improve diagnosis, reduce delays, and optimize treatment strategies.

Preventing recurrence of endometriosis-related pain by means of long-acting progestogen therapy: the PRE-EMPT RCT.

Cooper KG, Bhattacharya S, Daniels JP, Cheed V, Gennard L, Leighton L · Health technology assessment (Winchester, England) · 2024 · n=10

Endometriosis affects 1 in 10 women, many of whom have surgery for persistent pain. Recurrence of symptoms following an operation is common. Although hormonal treatment can reduce this risk, there is uncertainty about the best option. To evaluate the clinical and cost-effectiveness of long-acting progestogen therapy compared with the combined oral contraceptive pill in preventing recurrence of endometriosis-related pain and quality of life. A multicentre, open, randomised trial with parallel economic evaluation. The final design was informed by a pilot study, qualitative exploration of women's lived experience of endometriosis and a pretrial economic model. Thirty-four United Kingdom hospitals. Women of reproductive age undergoing conservative surgery for endometriosis. Long-acting progestogen reversible contraceptive (either 150 mg depot medroxyprogesterone acetate or 52 mg levonorgestrel-releasing intrauterine system) or combined oral contraceptive pill (30 µg ethinylestrad

Efficacy of acupuncture for endometriosis-associated pain: a multicenter randomized single-blind placebo-controlled trial.

Li PS, Peng XM, Niu XX, Xu L, Hung Yu Ng E, Wang CC · Fertility and sterility · 2023 · n=106

To evaluate the efficacy and safety of acupuncture in the treatment of endometriosis-associated pain. A multicenter, randomized, single-blind, placebo-controlled trial. Four tertiary hospitals in Jiangxi and Hainan Provinces. Women with endometriosis-associated pain aged between 20 and 40 years. Subjects were assigned randomly to receive either acupuncture or sham acupuncture treatment for 12 weeks, starting one week before each expected menstruation and administered as a 30-minute session once per day, 3 times a week. During the menstruation period, acupuncture was administered daily when pelvic pain associated with endometriosis occurred. After acupuncture or sham acupuncture treatment, the subjects were followed for another 12 weeks. Changes in maximum pain as assessed with the visual analog scale (VAS) for various pelvic pain, duration of dysmenorrhea, and scores on the Multidimensional Pain Inventory, Beck Depression Inventory, Profile of Mood States, and Endometriosis Health

The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial.

Amini L, Chekini R, Nateghi MR, Haghani H, Jamialahmadi T, Sathyapalan T · Pain research & management · 2021 · n=60

Endometriosis is a chronic and estrogen-dependent pelvic inflammatory disease, which may have various causes, such as oxidative stress. Dysmenorrhea, dyspareunia, and pelvic pain are well-known symptoms of endometriosis. The present clinical trial assessed the role of supplementation with antioxidant vitamins on the indices of oxidative stress as well as the severity of pain in women with endometriosis. We enrolled 60 reproductive-aged (15-45 years) women with pelvic pain in this triple-blind clinical trial. They had 1-3 stages of laparoscopic-proven endometriosis. The participants were randomized to group A (n = 30), given vitamin C (1000 mg/day, 2 tablets of 500 mg each) and vitamin E (800 IU/day, 2 tablets of 400 IU each) combination, or group B (n = 30), given placebo pills daily for 8 weeks. Following treatment with vitamin C and vitamin E, we found a significant reduction in MDA and ROS compared with the placebo group. The

Dietary Supplements for Endometriosis-Associated Pain: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.

Salmeri N, Ragusi A, Buffo C, Somigliana E, Viganò P, Vercellini P · Gynecologic and obstetric investigation · 2026 · n=545

<p>Introduction: In recent years, dietary supplements have emerged as popular "natural" alternatives to conventional pharmacological treatments for various conditions, including endometriosis. The growing popularity of supplements for endometriosis-associated pain, fueled by an expanding and minimally regulated market, underscores the need for robust evidence of efficacy, as a prerequisite for any consideration on effectiveness. This meta-analysis synthesizes evidence from randomized, placebo-controlled trials (RCTs), the gold standard in evidence-based medicine, to assess the efficacy of dietary supplements in endometriosis-associated pain. A systematic search of PubMed, Embase, Scopus, and the Cochrane Library was conducted up to November 5, 2024, in adherence to PRISMA 2020 guidelines. Two independent reviewers screened studies using PICOS criteria: reproductive-age women with endometriosis (Population), dietary supplements (Intervention), placebo (Comparator), and pain-relat

Nutrition Interventions in the Treatment of Endometriosis: A Scoping Review.

De Araugo SC, Varney JE, McGuinness AJ, Naude C, Evans S, Mikocka-Walus A · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025

Pain, poor quality of life (QOL) and gastrointestinal (GI) symptoms are commonly experienced by individuals with endometriosis. Although diet and nutrition supplements are frequently used to manage endometriosis-related symptoms, there is limited understanding of the breadth and quality of research in this field. Our aim was to undertake a scoping review of diet and nutrition supplement intervention studies in people with endometriosis, diagnosed by ultrasound or surgery. MEDLINE Complete, Embase, CINAHL and PsycINFO databases were searched for articles published in English from database inception to November 2024. Quality was assessed by two reviewers independently using the Joanna Briggs Institute appraisal tools. In total, 5130 publications were screened and 13 were included. Among these, five evaluated the effect of diet intervention, one evaluated the effect of a combined diet-supplement intervention and seven evaluated the effect of a nutrition supplement in endometriosis. Over

Pharmacologic Interventions for Endometriosis-Related Pain: A Systematic Review and Meta-analysis.

Kou L, Huang C, Xiao D, Liao S, Li Y, Wang Q · Obstetrics and gynecology · 2025 · n=665

To evaluate the effectiveness of various medications for the treatment of endometriosis-related pain through a network meta-analysis. A comprehensive search was conducted in PubMed, Embase, Web of Science, and the Cochrane Controlled Trials Register until July 22, 2024. We also searched ClinicalTrials.gov for additional data on recently completed trials or potentially eligible randomized controlled trials (RCTs) but found nothing. The analysis included randomized RCTs that used pharmacologic interventions for managing endometriosis-related pain. The primary efficacy outcome was endometriosis-associated pelvic pain, which included dysmenorrhea, dyspareunia, and nonmenstrual pelvic pain. The analysis adhered to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. A total of 31 RCTs involving 8,665 patients were included in the analysis. In terms of endometriosis-associated pelvic pain, four interventions demonstrated significantly greater efficac

Endometriosis: Diagnosis and Treatment

ReproductiveFacts

Published by the American Society for Reproductive Medicine (ASRM), this resource offers patient-friendly information on endometriosis, covering its causes, symptoms, diagnosis, and various treatment options.

Endometriosis

NHS

This page provides comprehensive information about endometriosis, including its symptoms, causes, diagnosis, and treatment options. It is aimed at the general public seeking reliable health information.

Comparing the Safety and Efficacy in the Use of Dienogest, Leuprolide Acetate, DMPA and Combined Oral Contraceptive Pills (Microgynon) on Endometriosis Patients After Conservative Surgery

n=80 · NCT06145438 · COMPLETED · COMPLETED

The goal of this clinical trial is to compare safety and efficacy in endometriosis patient after conservative surgery. The main question\[s\] it aims to answer are: 1. Health-related quality of life (HRQoL) 2. VAS score 3. Beta estradiol 4. TNF Alpha 5. Adnexal mass recurrence Participants will be randomized into 4 groups, each group will receive: 1. Leuprolide Acetate injection/month 2. Dienogest 2 mg/day 3. COC (mycrogynon)/day 4. DMPA injection 150mg/month Researcher will compare the efficacy and safety in the assigned group.

Pathways for Patient-centered Diagnosis and Management of Endometriosis-associated Deep Dyspareunia: A Pilot Randomized Trial

n=30 · NCT04370444 · COMPLETED · COMPLETED

The purpose of this study is to evaluate the acceptability and effectiveness of two tools that may help address the management of deep dyspareunia: 1) A phallus length reducer (PLR, brand name: Ohnut), consisting of 4 interconnected silicone rings worn externally over the penetrating object to reduce pain with deep penetration by allowing adjustable limitation of penetration depth, and 2) A vaginal insert for at home self-assessment of the extent and severity of deep dyspareunia.

Evaluation of the Long-term Therapeutic Effect of High-Intensity Focused Ultrasound (HIFU) Treatment in Patients With Rectal Endometriosis

n=140 · NCT07179419 · RECRUITING · RECRUITING

Evaluate the long-term effects of HIFU treatment for rectal endometriosis.

Cochrane reviews on Endometriosis

Cochrane

Cochrane Library provides systematic reviews and meta-analyses of healthcare interventions, offering high-quality evidence summary for various treatments related to endometriosis. This link directs to a search for relevant reviews.

TRIP Database search: Endometriosis

TRIP Database

TRIP Database is a clinical search engine designed to allow users to quickly and easily find high-quality research evidence to support their practice. This search link provides access to various evidence types on endometriosis.

Endometriosis reviews

Cochrane

Cochrane Library provides a collection of systematic reviews and meta-analyses related to endometriosis, evaluating the effectiveness of various diagnostic and treatment interventions. These reviews are high-quality, synthesized evidence.