Seasonal Allergies

Risk of hypospadias in offspring of women using loratadine during pregnancy: a systematic review and meta-analysis.

Schwarz EB, Moretti ME, Nayak S, Koren G · Drug safety · 2008

Loratadine, a second-generation antihistamine, is commonly used to treat seasonal allergies. Some studies have suggested that use of loratadine by pregnant women increases the risk of hypospadias in male offspring. This meta-analysis was designed to assess the strength of the association between loratadine and hypospadias. To locate pertinent articles published in any language from January 1989 until August 2007, we searched electronic databases (MEDLINE, OVID, EMBASE, SCOPUS, TOXLINE Special, ReproTox, TERIS, CINAHL and others), conference proceedings and bibliographies. Studies were eligible for this analysis if they were cohort, case-control or case series studies that reported the incidence of hypospadias in the offspring of women who were or were not exposed to loratadine during pregnancy. Two authors independently extracted information on study design, participant characteristics, measures of outcome, control for potential confounding factors and risk estimates using a standard

Are the clinical effects of homeopathy placebo effects? A meta-analysis of placebo-controlled trials.

Linde K, Clausius N, Ramirez G, Melchart D, Eitel F, Hedges LV · Lancet (London, England) · 1997

Homeopathy seems scientifically implausible, but has widespread use. We aimed to assess whether the clinical effect reported in randomised controlled trials of homeopathic remedies is equivalent to that reported for placebo. We sought studies from computerised bibliographies and contracts with researchers, institutions, manufacturers, individual collectors, homeopathic conference proceedings, and books. We included all languages. Double-blind and/or randomised placebo-controlled trials of clinical conditions were considered. Our review of 185 trials identified 119 that met the inclusion criteria. 89 had adequate data for meta-analysis, and two sets of trial were used to assess reproducibility. Two reviewers assessed study quality with two scales and extracted data for information on clinical condition, homeopathy type, dilution, "remedy", population, and outcomes. The combined odds ratio for the 89 studies entered into the main meta-analysis was 2.45 (95% CI 2.05, 2.93) in favour of

Clinical inquiries. Intranasal steroids vs antihistamines: which is better for seasonal allergies and conjunctivitis?

Parle-Pechera S, Powers L, St Anna L · The Journal of family practice · 2012

Intranasal steroids provide better relief for adult sufferers, according to nonstandardized, nonclinically validated scales. Steroids reduce subjective total nasal symptom scores (TNSS)--representing sneezing, itching, congestion, and rhinorrhea--by about 25% more than placebo, whereas oral antihistamines decrease TNSS by 5% to 10% (strength of recommendation [SOR]: B, systematic review of randomized controlled trials [RCTs], most without clinically validated or standardized outcome measures). Intranasal steroids improve subjective eye symptom scores as well as (or better than) oral antihistamines in adults who also have allergic conjunctivitis (SOR: A, systematic review, RCTs).

Immunomodulatory dietary polysaccharides: a systematic review of the literature.

Ramberg JE, Nelson ED, Sinnott RA · Nutrition journal · 2010

A large body of literature suggests that certain polysaccharides affect immune system function. Much of this literature, however, consists of in vitro studies or studies in which polysaccharides were injected. Their immunologic effects following oral administration is less clear. The purpose of this systematic review was to consolidate and evaluate the available data regarding the specific immunologic effects of dietary polysaccharides. Studies were identified by conducting PubMed and Google Scholar electronic searches and through reviews of polysaccharide article bibliographies. Only articles published in English were included in this review. Two researchers reviewed data on study design, control, sample size, results, and nature of outcome measures. Subsequent searches were conducted to gather information about polysaccharide safety, structure and composition, and disposition. We found 62 publications reporting statistically significant effects of orally ingested glucans, pectins,

Efficacy and safety of a particulate yeast β-glucan preparation in the treatment of seasonal allergic rhinitis (BETALL): a randomised placebo-controlled crossover trial protocol.

Briskey D, Pellow J, Beatson G, Tremblay A, Rao A, Tompkins TA · Trials · 2026

Allergic rhinitis (AR) has been shown to be a significant global health burden. Despite the existence of pharmacological treatments, mainly antihistamines, nasal corticosteroids, and decongestants, many individuals with seasonal allergies turn to alternative herbal medicines and nutritional supplements for the management of symptoms. The primary objective of the current study is to evaluate the efficacy and safety of a 500 mg daily dose of a yeast β-glucan preparation (M-Gard®) on reducing the severity of nasal and ocular symptoms in a population with seasonal AR. This randomised placebo-controlled crossover trial will evaluate the effect of 500 mg of a 14-day M-Gard® or placebo (microcrystalline cellulose) supplementation period on the relief of grass pollen-induced AR symptoms in 20 generally healthy adults (18-65 years) with a history of recurrent seasonal AR. Participants will consume M-Gard® or placebo during 14 days, starting 12 days

Lasmiditan in Japanese Patients with Common Migraine Comorbidities or Concomitant Medications: A Post Hoc Safety and Efficacy Analysis from the MONONOFU Study.

Kitamura S, Imai N, Tanji Y, Ozeki A, Komori M · Journal of pain research · 2023

Migraine is often comorbid with other disorders. People with migraine may be prescribed one or more concomitant medications. This post hoc analysis assessed the safety and efficacy of lasmiditan in Japanese people with migraine comorbidities or using concomitant medications. The MONONOFU study was a Phase 2, randomized, placebo-controlled, multicenter study of lasmiditan for acute migraine treatment in Japanese adults. Patients reported comorbidities (pre-existing or coexisting conditions) during screening. Concomitant medications (any drugs taken ±48 hours of the study drug) and treatment-emergent adverse events (TEAEs) were recorded in a paper diary. Study drug efficacy (pain freedom 2 hours after administration of study drug) was reported in an eDiary. Logistic regression models were used for subgroup analyses of safety (incidence of TEAEs) and efficacy (pain freedom at 2 hours post dose) of lasmiditan in relation to presence/absence of comorbidities, and safety in relati

Probiotics (Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2) improve rhinoconjunctivitis-specific quality of life in individuals with seasonal allergies: a double-blind, placebo-controlled, randomized trial.

Dennis-Wall JC, Culpepper T, Nieves C Jr, Rowe CC, Burns AM, Rusch CT · The American journal of clinical nutrition · 2017 · n=37

Background: Rhinoconjunctivitis-specific quality of life is often reduced during seasonal allergies. The Mini Rhinoconjunctivitis Quality of Life Questionnaire (MRQLQ) is a validated tool used to measure quality of life in people experiencing allergies (0 = not troubled to 6 = extremely troubled). Probiotics may improve quality of life during allergy season by increasing the percentage of regulatory T cells (Tregs) and inducing tolerance.Objective: The objective of this study was to determine whether consuming Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and B. longum MM-2 compared with placebo would result in beneficial effects on MRQLQ scores throughout allergy season in individuals who typically experience seasonal allergies. Secondary outcomes included changes in immune markers as part of a potential mechanism for changes in MRQLQ scores.Design: In this double-blind, placebo-controlled, parallel, randomized clinical trial, 173 participants (mean ± SEM: age 27 &#x

Allergic phenotypes and asthma in multiple sclerosis: Epidemiologic and genetic relationships.

Briggs F, Nyati A, Zweig S, Leung LJ · Multiple sclerosis (Houndmills, Basingstoke, England) · 2026

Multiple sclerosis (MS) and allergic disorders (ADs) are classically seen as immunologically distinct, and prior studies suggest potential inverse associations and overlapping genetic contributors. Compare the prevalence of asthma, and dietary and environmental allergic phenotypes in persons with MS (PwMS) versus unaffected controls, compare AD prevalence by MS clinical course, and evaluate associations between MS genetic risk, HLA-DRB1*15:01 and a non-MHC genetic risk score (GRS), and ADs in PwMS. We analyzed survey and genotype data from 1542 PwMS and 700 controls from the Accelerated Cure Project. Logistic regression models were adjusted for key confounders. Genetic analyses included 1252 unrelated non-Hispanic White PwMS, assessing the main effects of HLA-DRB1*15:01 and the GRS. Benjamini-Hochberg procedure controlled the false discovery rate. PwMS had lower odds of seasonal allergies compared to controls (OR = 0.79; 95% CI: 0.65, 0.96), with a non-significant redu

Inhalation and inflammation: examining aeroallergens and eosinophilic esophagitis.

Sekar S, Kelly K, Sheth D, Papademetriou M · Frontiers in allergy · 2025

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease leading to inflammation in the esophageal lining. EoE has become a significant cause of gastrointestinal illness in both children and adults. While there is significant focus on dietary triggers in the pathophysiology of the disease, aeroallergens are also increasingly implicated in both the development and clinical presentation. Possible mechanisms, seasonality and current evidence for the role of aeroallergens in EoE are discussed, including seasonality, allergen specific mechanisms and therapeutic options. A multidisciplinary team between allergists and gastroenterologists is optimal for coordinated patient management.

2025

Hay Fever

NIH/MedlinePlus

This page from MedlinePlus provides comprehensive information on hay fever (allergic rhinitis), including causes, symptoms, diagnosis, treatment, and prevention strategies. It offers a general overview for the public on managing seasonal allergies.

Allergic Rhinitis (Hay Fever)

American Academy of Allergy, Asthma & Immunology (AAAAI) (via NIH/MedlinePlus)

This MedlinePlus article, referencing the AAAAI, details allergic rhinitis, its epidemiology, clinical presentation, and standard management approaches.

Seasonal Allergies at a Glance

NCCIH

NCCIH provides a brief overview of seasonal allergies, including common symptoms and what the science says about complementary health approaches for treatment.

A Randomised, Double-Blind, Placebo-Controlled, Two-Week Crossover, Knemometric Assessment of the Effect of Fluticasone Furoate Nasal Spray 100mcg Once Daily on Short-Term Growth in Children Aged 6 to 11 Years With Seasonal and/or Perennial Allergic Rhinitis

n=56 · NCT00109486 · COMPLETED · COMPLETED

The purpose of this study is to assess any effect in children with seasonal and/or perennial allergic rhinitis by GW685698X aqueous nasal spray (versus vehicle placebo nasal spray) on growth using knemometry.

A Randomized Study to Evaluate a Novel Method of Specific Allergen Immunotherapy in Grass and/or Tree Pollen Allergic Subjects by Intralymphatic Allergen Administration

n=156 · NCT00470457 · COMPLETED · COMPLETED

Allergen specific immunotherapy (SIT) is the only causative treatment of IgE-mediated allergies. The disadvantages of SIT, however, are the requirement of numerous allergen administrations over three to five years, and that the treatment itself causes frequent allergic reactions. We aim at enhancing grass pollen SIT in hay fever patients by injecting the allergen directly into subcutaneous lymph nodes. In a monocentric randomized trial safety and efficacy of intralymphatic immunotherapy (ILIT) with 3 low dose grass pollen extract injections over 2 months are compared to subcutaneous immunotherapy (SCIT) using 54 injections over 3 years. * Trial with immunodulatory product / biological

Interventional, Non-comparative, Single-center PMCF Study to Evaluate Performance and Safety of "Xanoftal Next" Used to Attenuate Symptoms of Seasonal Allergic Conjunctivitis, Even When Associated With Dry Eye Syndrome

n=20 · NCT05829499 · COMPLETED · COMPLETED

Dry eye disease (DED), also called keratoconjunctivitis sicca, is a multifactorial disease of the ocular surface characterized by loss of homeostasis of the tear film and accompanied by symptoms such as ocular discomfort and visual disturbance. Patients with moderate-to-severe DED may experience a reduced quality of life due to ocular pain, difficulty in performing daily activities, and depression. Traditionally, dry eye syndrome and allergic conjunctivitis are regarded as 2 different diseases. However, recent literature has shown both conditions share similar characteristics, including several of their signs and symptoms (e.g. red, itchy, watery, and burning eyes). On the other hand, red swollen eyelids, burning sensations, ocular irritation, loss of eyelashes and misdirected eyelashes are also common symptoms of Blepharitis, an inflammatory disorder of eyelids affecting all the age and ethnic groups. First-line therapy for treating dry eye symptoms consists of over the counter (OTC) artificial tear drops, gels, ointments, or lubricants. Manufacturers have developed OTC products that appear to mimic the different layers of the tear film in order to maintain ocular hydration. For these reasons, an interventional, non-comparative, Post Marketing Clinical Follow-up (PMCF) study was planned to evaluate the performance and safety of "Xanoftal Next" used to attenuate symptoms of seasonal allergic conjunctivitis, even when associated with dry eye syndrome. The objectives of the PMCF study are confirmation of the performance, collection of additional safety data regarding expected adverse events and detection of potential unexpected adverse events associated with use of "Xanoftal Next" according to the Instructions for Use (IFU). Each subject, after signing the Informed Consent Form, will enter the screening and baseline phase (the 2 visits will coincide) during which baseline procedures will be completed. At baseline visit, the "Xanoftal Next" product will be administered to the enrolled subject. The patient will perform 2 on-site visits: V0 and V2/EOS. To monitor the safety, 1 phone contact is planned (V1) to check for potential adverse events and concomitant medications intake.

Search: Seasonal Allergies

TRIP Database

TRIP Database is a clinical search engine designed to allow users to quickly and easily find high-quality evidence-based healthcare information. A search for 'Seasonal Allergies' provides access to a wide range of guidelines, systematic reviews, and other evidence.

Search: Seasonal Allergic Rhinitis

Cochrane

The Cochrane Library is a collection of databases that contain different types of high-quality, independent evidence to inform healthcare decision-making, including systematic reviews. A search for 'Seasonal Allergic Rhinitis' yields relevant reviews on various interventions.