Eczema (Atopic Dermatitis)

Probiotics for pediatric atopic dermatitis: A systematic review and meta-analysis of randomized controlled trials.

Arif MI, Dai Q, Ru L · The journal of allergy and clinical immunology. Global · 2026

Atopic dermatitis is a prevalent chronic inflammatory skin disease in children and the severity of the disease can be affected by modulation of gut microbiota through probiotics. Nonetheless, the clinical trial outcomes on the effectiveness of probiotics in child atopic dermatitis are inconclusive. We sought to compare the effects of using probiotics in comparison with placebo in children/adolescents with eczema/atopic dermatitis. We searched PubMed/MEDLINE, Google Scholar, and Cochrane Library from inception to March 2025. Statistical analyses were done in Review Manager version 5.4.1 (The Nordic Cochrane Centre, Copenhagen, Denmark). Pooling the trials using a fixed effect yielded standard mean difference (SMD) with 95% CI. A total of 13 randomized controlled trials were used. SCORing Atopic Dermatitis (SCORAD) was used for assessing the efficacy of probiotics on atopic dermatitis. Subgroup analysis demonstrated a statistically nonsignificant difference in SCORAD within the first

Topical anti-inflammatory treatments for eczema: network meta-analysis.

Lax SJ, Van Vogt E, Candy B, Steele L, Reynolds C, Stuart B · The Cochrane database of systematic reviews · 2024 · n=846

Eczema (atopic dermatitis) is the most burdensome skin condition worldwide and cannot currently be prevented or cured. Topical anti-inflammatory treatments are used to control eczema symptoms, but there is uncertainty about the relative effectiveness and safety of different topical anti-inflammatory treatments. To compare and rank the efficacy and safety of topical anti-inflammatory treatments for people with eczema using a network meta-analysis. We searched the Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase and trial registries on 29 June 2023, and checked the reference lists of included studies. We included within-participant or between-participant randomised controlled trials (RCTs) in people of any age with eczema of any severity, but excluded trials in clinically infected eczema, seborrhoeic eczema, contact eczema, or hand eczema. We included topical anti-inflammatory treatments used for at least one week, compared with another anti-inflammatory treatment, no trea

Ambient air pollutants increase the risk of immunoglobulin E-mediated allergic diseases: a systematic review and meta-analysis.

Wang H, Li XB, Chu XJ, Cao NW, Wu H, Huang RG · Environmental science and pollution research international · 2022

Immunoglobulin E (IgE)-mediated allergic diseases, including eczema, atopic dermatitis (AD), and allergic rhinitis (AR), have increased prevalence in recent decades. Recent studies have proved that environmental pollution might have correlations with IgE-mediated allergic diseases, but existing research findings were controversial. Thus, we performed a comprehensive meta-analysis from published observational studies to evaluate the risk of long-term and short-term exposure to air pollutants on eczema, AD, and AR in the population (per 10-μg/m3 increase in PM2.5 and PM10; per 1-ppb increase in SO2, NO2, CO, and O3). PubMed, Embase, and Web of Science were searched to identify qualified literatures. The Cochran Q test was used to assess heterogeneity and quantified with the I2 statistic. Pooled effects and the 95% confidence intervals (CIs) were used to evaluate outcome effects. A total of 55 articles were included in the study. The results showed that long-term and short-term expo

Maternal atopic conditions and autism spectrum disorder: a systematic review.

Seker A, Qirko-Gurakuqi A, Tabaku M, Javate KRP, Rathwell I · European child & adolescent psychiatry · 2024

Autism spectrum disorder (ASD) is a disabling neurodevelopmental condition with complex etiology. Emerging evidence has pointed to maternal atopy as a possible risk factor. It is hypothesized that maternal atopic disease during pregnancy can lead to increased levels of inflammatory cytokines in fetal circulation via placental transfer or increased production. These cytokines can then pass through the immature blood-brain barrier, causing aberrant neurodevelopment via mechanisms including premature microglial activation. The objective of this study is to systematically review observational studies that investigate whether a maternal history of atopic disease (asthma, allergy, or eczema/atopic dermatitis) is associated with a diagnosis of ASD in offspring. A search was conducted in Ovid MEDLINE, PsycINFO, and Embase databases for relevant articles up to November 2021; this was later updated in January 2022. Observational studies published in peer-reviewed journals were included. Data wer

Atopic eczema in children and young people: management

NICE

This guideline covers diagnosing and managing atopic eczema in children and young people. It aims to improve care by providing recommendations on emollients, topical corticosteroids, and other treatments.

Combining treat-to-target principles and shared decision-making: International expert consensus-based recommendations with a novel concept for minimal disease activity criteria in atopic dermatitis.

Silverberg JI, Gooderham M, Katoh N, Aoki V, Pink AE, Binamer Y · Journal of the European Academy of Dermatology and Venereology : JEADV · 2024

Current treat-to-target recommendations for atopic dermatitis (AD) may not include high enough treatment targets and do not fully consider patient needs. To develop recommendations for optimized AD management, including disease severity assessments, treatment goals and targets, and guidance for treatment escalation/modification. An international group of expert dermatologists drafted a series of recommendations for AD management using insights from a global patient study and 87 expert dermatologists from 44 countries. Experts voted on recommendations using a modified eDelphi voting process. The Aiming High in Eczema/Atopic Dermatitis (AHEAD) recommendations establish a novel approach to AD management, incorporating shared decision-making and a concept for minimal disease activity (MDA). Consensus (≥70% agreement) was reached for all recommendations in 1 round of voting; strong consensus (≥90% agreement) was reached for 30/34 recommendations. In the AHEAD approach, pati

Hand Sanitizer: Stopping the Spread of Infection at a Cost.

Bhatt S, Patel A, Kesselman MM, Demory ML · Cureus · 2024

The recent rise in hand sanitizer use due to the COVID-19 pandemic has had a beneficial impact on stopping the spread of disease, but the potential negative implications of its overuse on the body and the microbiome have yet to be thoroughly reviewed. Epidermal layers absorb hand sanitizer from direct application to the skin, making them some of the most susceptible cells to the adverse effects of overuse. The increased usage of hand sanitizer can affect the variation, quantity, and diversity of the skin microflora, leading to conditions such as eczema, atopic dermatitis, and even systemic toxicity due to colonization of the skin with pathogenic bacteria. Due to the close-knit relationship between the skin and gut, the gastrointestinal system can also incur disruptions due to the negative effects on the skin as a result of excessive hand sanitizer use, leading to gut dysbiosis. Additionally, the accidental ingestion of hand sanitizer, and its abuse or misuse, can be toxic and lead to a

[Medical clinical diagnostics for indoor mould exposure - Update 2023 (AWMF Register No. 161/001)].

Hurraß J, Heinzow B, Walser-Reichenbach S, Aurbach U, Becker S, Bellmann R · Pneumologie (Stuttgart, Germany) · 2024

This article is an abridged version of the updated AWMF mould guideline "Medical clinical diagnostics in case of indoor mould exposure - Update 2023", presented in July 2023 by the German Society of Hygiene, Environmental Medicine and Preventive Medicine (Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin, GHUP), in collaboration with German and Austrian scientific medical societies, and experts. Indoor mould growth is a potential health risk, even if a quantitative and/or causal relationship between the occurrence of individual mould species and health problems has yet to be established. There is no evidence for a causal relationship between moisture/mould damage and human diseases, mainly because of the ubiquitous presence of fungi and hitherto inadequate diagnostic methods. Sufficient evidence for an association between moisture/mould damage and the following health effects has been established for: allergic respiratory diseases, allergic rhinitis, allergic rhino

Eczema

NIH/MedlinePlus

MedlinePlus offers extensive information on eczema, including causes, symptoms, treatments, and lifestyle changes. It compiles information from various authoritative sources like the National Institute of Allergy and Infectious Diseases.

Atopic eczema

NHS

This NHS page provides comprehensive information on atopic eczema, including symptoms, causes, diagnosis, and treatment options. It is a reliable resource for public health information.

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Ranging Study Investigating the Efficacy, Safety, and Pharmacokinetic Profile of ANB020 Administered to Adult Subjects With Moderate-to-Severe Atopic Dermatitis

n=302 · NCT03533751 · COMPLETED · COMPLETED

This study is designed to evaluate the efficacy, safety, and pharmacokinetic (PK) profiles of multiple doses of etokimab in adult participants with atopic dermatitis (AD).

Clinical Study to Evaluate the Safety, Pharmacokinetics and Efficacy of VC005 in Adolescent Subjects With Mild to Moderate Atopic Dermatitis

n=11 · NCT07329101 · COMPLETED · COMPLETED

This is a single arm, and open-label phase I study

Efficacy of Acupuncture in the Treatment of Moderate-to-severe Atopic Dermatitis: a Multicentre Randomised Sham-controlled Clinical Trial

n=110 · NCT06922565 · NOT_YET_RECRUITING · NOT_YET_RECRUITING

This study used a multicentre parallel three-armed randomised sham-controlled clinical trial methodology in order to objectively and normatively assess the efficacy of acupuncture on Quchi the Sea of Blood the Foot Sanli and the Sanyinjiao in the treatment of moderate-to-severe atopic dermatitis so as to obtain high-level evidence-based medical evidence. This study adopts a multi-centre, parallel, three-armed, randomized, sham-controlled clinical trial method, and will be conducted at Yueyang Hospital of Integrative Medicine affiliated with Shanghai University of Traditional Chinese Medicine, Huashan Hospital affiliated with Fudan University, and Seventh People's Hospital affiliated with Shanghai University of Traditional Chinese Medicine. Eligible patients with moderate-to-severe AD will be divided into three groups using stratified block randomisation in the ratio of 2:2:1: the acupuncture group, the sham-acupuncture group and the waitlisted control group. The total observation period is 9 weeks, including a 1-week introduction period, a 4-week treatment period and a 4-week follow-up period.

Cochrane reviews on Atopic Eczema

Cochrane

The Cochrane Library provides high-quality, independent evidence to inform healthcare decision-making, offering numerous systematic reviews and meta-analyses related to atopic eczema interventions.

Cochrane reviews on Atopic dermatitis

Cochrane

Cochrane Library provides systematic reviews and meta-analyses of healthcare interventions, including numerous reviews related to atopic dermatitis. It's a key resource for evidence-based healthcare decisions.

Eczema (Atopic Dermatitis)

TRIP Database

TRIP Database provides a comprehensive search engine for clinical evidence, including guidelines, systematic reviews, and primary research, for eczema (atopic dermatitis).