Primary hypothyroidism is a condition where the thyroid gland does not produce enough thyroid hormones, leading to a slowdown of various bodily functions.
Ranked by community outcomes, then evidence grade, Health Voice mentions, and recency.
Why it may help Primary Hypothyroidism: Often low in hypothyroidism
Why it may help Primary Hypothyroidism: Co-factor in thyroid metabolism
Why it may help Primary Hypothyroidism: Ginseng may support thyroid function by modulating the hypothalamic-pituitary-adrenal (HPA) axis and reducing stress, which can indirectly influence thyroid hormone production and conversion.
Why it may help Primary Hypothyroidism: Rhodiola rosea may help manage symptoms associated with hypothyroidism, such as fatigue and low mood, by modulating the stress response and improving cellular energy production.
Why it may help Primary Hypothyroidism: Reduces thyroid inflammation
Why it may help Primary Hypothyroidism: Supports T4-to-T3 conversion
Why it may help Primary Hypothyroidism: Iodine is an essential component of thyroid hormones (T3 and T4); adequate intake is crucial for the synthesis of these hormones, which regulate metabolism and energy production.
Why it may help Primary Hypothyroidism: Iron is essential for the activity of thyroid peroxidase, an enzyme critical for the synthesis of thyroid hormones; iron deficiency can impair thyroid hormone production.
Why it may help Primary Hypothyroidism: Modestly raises thyroid hormones
Why it may help Primary Hypothyroidism: Whole-food selenium
Why it may help Primary Hypothyroidism: Substrate for thyroid hormone
Why it may help Primary Hypothyroidism: Omega-3 fatty acids may reduce inflammation and support overall cellular function, potentially benefiting thyroid health by mitigating autoimmune processes and improving hormone receptor sensitivity.
Why it may help Primary Hypothyroidism: Probiotics may indirectly support thyroid function by improving gut health and reducing inflammation, which can impact the absorption of nutrients essential for thyroid hormone production and conversion.
Why it may help Primary Hypothyroidism: Magnesium is a cofactor for enzymes involved in thyroid hormone synthesis and conversion, and adequate levels are essential for optimal thyroid function and energy metabolism.
Why it may help Primary Hypothyroidism: L-Tyrosine is a precursor to thyroid hormones; its adequate availability is essential for the synthesis of thyroxine (T4) and triiodothyronine (T3) by the thyroid gland.
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Community Discussions
How global health authorities view Primary Hypothyroidism.
Major health organizations like the Mayo Clinic and NIH acknowledge the importance of essential nutrients like iodine and selenium for thyroid health. While conventional treatment for primary hypothyroidism primarily involves thyroid hormone replacement, some organizations, such as the NCCIH, recognize the use of certain adaptogenic herbs like Ashwagandha for stress and fatigue, which can be symptoms of hypothyroidism, though not as a direct treatment for the thyroid condition itself. The role of specific dietary patterns and micronutrient supplementation beyond addressing deficiencies is an area of ongoing research, with a general consensus on the importance of a balanced diet for overall health.
Indexed studies for Primary Hypothyroidism, grouped by source type and quality.
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Pooled analyses across multiple human trials.
Mantovani A, Nascimbeni F, Lonardo A, Zoppini G, Bonora E, Mantzoros CS · Thyroid : official journal of the American Thyroid Association · 2018
It is currently uncertain whether primary hypothyroidism is associated with nonalcoholic fatty liver disease (NAFLD). We performed a meta-analysis of relevant studies to quantify the magnitude of association between primary hypothyroidism and risk of NAFLD. We searched PubMed, Web of Science and Scopus databases from January 2000 to March 2018 using predefined keywords to identify observational cross-sectional, case-control, and longitudinal studies in which NAFLD was diagnosed by imaging or biopsy. Data from selected studies were extracted and meta-analysis was performed using random-effects modeling. A total of 12 cross-sectional and 3 longitudinal studies enrolling 44,140 individuals were included in the final analysis. Hypothyroidism (defined either by self-reported history of hypothyroidism with use of levothyroxine replacement therapy or by presence of abnormal thyroid function tests) was associated with an increased risk of prevalent NAFLD (n = 12 studies; random
Recommendations from medical societies (NICE, AHA, ADA, ACG, Endocrine Society…).
Thyroid function disorders--Guidelines of the Netherlands Association of Internal Medicine.
Muller AF, Berghout A, Wiersinga WM, Kooy A, Smits JW, Hermus AR · The Netherlands journal of medicine · 2008
Thyroid function disorders are common with a female to male ratio of 4 to 1. In adult women primary hypothyroidism and thyrotoxicosis have a prevalence of 3.5/1000 and 0.8/1000, respectively. This guideline is aimed at secondary care providers especially internists, but also contains relevant information for interested general practitioners and gynaecologists. A multidisciplinary working group, containing delegates of professional and patient organisations, prepared the guideline. According to principles of 'evidence-based medicine' available literature was studied and discussed. Considering the availability and quality of published studies a practical advice was formulated. For a full overview of the literature and considerations the reader is referred to the original version of the guideline (accessible through NIV-net). In this manuscript we have aimed to provide the practicing internist with practical and 'as evidence-based as possible' treatment guidelines with respect to thyroid
Cohort, case-control, and cross-sectional human studies.
Drug-induced hypothyroidism in tuberculosis.
Quiroz-Aldave JE, Durand-Vásquez MDC, Gamarra-Osorio ER, Concepción-Urteaga LA, Pecho-Silva S, Rodríguez-Hidalgo LA · Expert review of endocrinology & metabolism · 2024
Adverse reactions to tuberculosis treatment can impact patient adherence and prognosis. Hypothyroidism is a frequent adverse reaction caused using ethionamide, prothionamide, and para-aminosalicylic acid and is often underdiagnosed. We searched Scielo, Scopus, and EMBASE databases, including 67 articles. Antitubercular drug-induced hypothyroidism has a prevalence of 17%. It occurs after 2 to 3 months of treatment and resolves within 4 to 6 weeks after discontinuation. It is postulated to result from the inhibition of thyroperoxidase function, blocking thyroid hormone synthesis. Symptoms are nonspecific, necessitating individualized thyroid-stimulating hormone measurement for detection. Specific guidelines for management are lacking, but initiation of treatment with levothyroxine, as is customary for primary hypothyroidism, is recommended. Discontinuation of antitubercular drugs is discouraged, as it may lead to unfavorable consequences. Antitubercular drug-induced hypot
Precocious Puberty: Types, Pathogenesis and Updated Management.
Alghamdi A · Cureus · 2023
Precocious puberty (PP) means the appearance of secondary sexual characters before the age of eight years in girls and nine years in boys. Puberty is indicated in girls by the enlargement of the breasts (thelarche) in girls and in boys by the enlargement of the testes in either volume or length (testicular volume = 4 mL, testicular length = 25 mm, or both). Two types of PP are recognized - namely central PP (CPP) and peripheral PP (PPP). This paper aims to describe the clinical findings and laboratory workup of PP and to illustrate the new trends in the management of precocious sexual maturation. Gonadotropin-releasing hormone (GnRH)-independent type (PPP) refers to the development of early pubertal maturation not related to the central activation of the hypothalamic-pituitary-gonadal (HPG) axis. It is classified into genetic or acquired disorders. The most common forms of congenital or genetic causes involve McCune-Albright syndrome (MAS), familial male-limited PP, and congenital adre
Acquired Hypothyroidism in Children.
Bhattacharyya SS, Singh A · Indian journal of pediatrics · 2023
Acquired hypothyroidism is generally also referred to as juvenile hypothyroidism. Hypothyroidism is due to the deficient secretion of thyroid hormones causing metabolic and neurological sequelae at the cellular level. It can present as overt hypothyroidism wherein the thyroid hormones (T4 and T3) secretion fall and thyrotropin (TSH) rises. Acquired hypothyroidism frequently presents between 9 and 11 y of age and is rarely seen before 4 y of age. Approximately 80% of the children and adolescents are asymptomatic at the time of diagnosis. Children with moderate to severe hypothyroidism often present for evaluation of poor growth, constipation, lethargy and/or dry skin. A detailed history and examination will provide us with enough clues for diagnosing hypothyroidism. Primary hypothyroidism can be diagnosed with raised TSH with subnormal levels of T3 and T4. Titres of thyroid antibodies - Anti-thyroperoxidase (TPO) and anti-thyroglobulin (ATG) antibodies, will be high in autoimmune hypoth
Public-health agencies: NCCIH, NIH, CDC, NHS.
World Health Organization (WHO)
While not directly about primary hypothyroidism, this WHO page provides data and information on iodine deficiency, a major cause of preventable hypothyroidism worldwide, and global efforts to address it.
Registered ongoing or completed trials (ClinicalTrials.gov).
n=62 · NCT06276205 · COMPLETED · COMPLETED
The goal of this clinical trial is to study the improvement of lipid levels in hypothyroid individuals after staring treatment. The main question it aims to answer is: • whether adding Vitamin D to standard therapy has any additional benefits Participants will be given Vitamin D in replacement doses according to their pre-existing Vitamin D level in addition to levothyroxine. Researchers will compare them with another group receiving only levothyroxine to see how much lipids improve in them
n=96 · NCT07408765 · RECRUITING · RECRUITING
Background. Primary hypothyroidism, both clinical and subclinical, is frequently associated with persistent fatigue, reduced psychological well-being, and lower levels of physical activity in adult women. However, evidence integrating these psychosocial factors remains limited and methodologically heterogeneous. Objective. To analyze the association between physical activity and fatigue, social support, and psychological well-being in women with primary hypothyroidism; to compare these profiles between clinical and subclinical hypothyroidism; and to explore the moderating effect of social support and psychological well-being on the relationship between fatigue and physical activity. Methods. An observational, analytical, multicenter cohort study will be conducted including 96 adult women with primary hypothyroidism from the Principality of Asturias. Physical activity levels will be assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), while fatigue, social support, and psychological well-being will be measured using the Fatigue Severity Scale (FSS), the Medical Outcomes Study Social Support Survey (MOS-SSS), and the WHO-5 Well-Being Index, respectively. Confounding variables will include age, body mass index, type of hypothyroidism (clinical or subclinical), and time since diagnosis. Descriptive analyses, comparisons between clinical and subclinical groups, and multiple linear regression models will be performed. Expected results. The study is expected to identify physical activity levels within the sample and determine which psychosocial factors are independently associated with physical activity. Additionally, fatigue is anticipated to be negatively associated with physical activity, whereas social support and psychological well-being are expected to show positive associations and potential moderating effects.
n=138 · NCT01145040 · UNKNOWN · UNKNOWN
The NOMOTHETICOS study is a unicentric cross-sectional study for a quantitative analysis of feedback-inhibition in the thyrotropic homeostatic control. Structural parameters are obtained in vivo from open-loop analysis in patients with disconnected feedback, i.e. with overt thyroid dysfunction or full dose substitution therapy with levothyroxine.
Conventional treatment for primary hypothyroidism involves daily thyroid hormone replacement therapy, typically with levothyroxine. This medication replaces the hormones your thyroid gland is no longer producing. Regular monitoring of TSH levels is crucial to ensure the correct dosage. It is important to take thyroid medication consistently and as prescribed, usually on an empty stomach, separate
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This information is for educational purposes only and not a substitute for professional medical advice. Always consult with a qualified healthcare provider before making any decisions about your health or treatment, especially regarding primary hypothyroidism.
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