Rosacea is a chronic inflammatory skin condition primarily affecting the face, characterized by redness, visible blood vessels, bumps, and sometimes eye irritation.
Ranked by community outcomes, then evidence grade, Health Voice mentions, and recency.
Why it may help Rosacea: Often low in rosacea
Why it may help Rosacea: Reduces inflammatory papules
Why it may help Rosacea: Aloe Vera gel, when applied topically, may alleviate rosacea symptoms by reducing inflammation and promoting skin healing, which can soothe redness and irritation.
Niacinamide is a form of vitamin B3 involved in essential cellular processes, recognized for its potential dermatological benefits without causing the typical 'niacin flush'.
Why it may help Rosacea: Licorice root, when applied topically, may reduce rosacea symptoms by inhibiting inflammatory pathways and providing antioxidant effects, thereby calming skin redness and irritation.
Zinc carnosine is a chelated mineral form studied for its roles in mucosal integrity and immune support. Research highlights its importance in addressing deficiencies linked to inflammatory and malabsorptive conditions.
Fat-soluble vitamin that directs calcium into bones and away from arteries.
Aerobic and resistance exercise have RCT-grade evidence for depression, comparable to SSRIs in mild-moderate cases.
Why it may help Rosacea: Anti-inflammatory for skin
Why it may help Rosacea: Topical and oral antioxidant
Why it may help Rosacea: Reduces skin inflammation
Why it may help Rosacea: Modulates gut-skin axis (SIBO link)
Why it may help Rosacea: Reduces flushing inflammation
Why it may help Rosacea: Chamomile, when applied topically, may reduce rosacea symptoms by exerting anti-inflammatory and antioxidant effects, which can calm skin redness and irritation.
Why it may help Rosacea: Algal oil, rich in omega-3 fatty acids, may reduce rosacea symptoms by decreasing systemic inflammation and modulating immune responses that contribute to skin redness and papules.
Community outcomes
Self-reported by community members · not medical advice.
Self-reported community outcomes. Not medical advice. Requires at least three reports per remedy to surface.
Community outcome data is still being collected for this ailment.
Be the first to share your experience →As more members share outcomes, RemedyAtlas will show which remedies helped people with similar conditions, symptoms, goals, and lab patterns.
Structured experience reports from people managing this condition. Not medical advice.
You can share without an account — we'll send a one-time code to verify your email. Or sign in.
Loading posts…
Community Discussions
How global health authorities view Rosacea.
The Mayo Clinic acknowledges that while there's no cure for rosacea, various treatments can control symptoms. They suggest identifying and avoiding triggers, and using gentle skin care. The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) also emphasizes trigger avoidance and sun protection. While conventional treatments are primary, some international bodies may mention the potential for complementary therapies to help manage symptoms, often with a call for more research. NCCIH notes that some botanicals are studied for skin conditions, but specific strong evidence for rosacea is often lacking.
Indexed studies for Rosacea, grouped by source type and quality.
Filter by source type
Pooled analyses across multiple human trials.
Efficacy and safety of oxymetazoline for the treatment of rosacea: A meta-analysis.
Liu F, Zhou Q, Wang H, Fu H, Li Y, Tao M · Journal of cosmetic dermatology · 2023
Since there is currently no conclusion on the efficacy and adverse effects of oxymetazoline, this meta-analysis attempts to explore its efficacy and adverse events, so as to provide guidance for clinical medication. We searched PubMed, Embase, and Cochrane Library from the establishment of the database to May 2021. We included studies that patients were randomly assigned to receive oxymetazoline or vehicle, and we excluded duplicate publications, research without full text, incomplete information or inability to conduct data extraction, animal experiments, reviews, and systematic reviews. STATA 15.1 was used to analyze the data. The pooled results show that the 3 (RR = 1.76, 95% CI: 1.53-2.03), 6 (RR = 1.71, 95% CI: 1.47-2.00), 9 (RR = 1.63, 95% CI: 1.40-1.90), 12 (RR = 1.41, 95% CI: 1.18-1.67) -hours CEA success rate and the 3 (RR = 1.65, 95% CI: 1.34-2.03), 6 (RR = 1.75, 95% CI: 1.43-2.14), 9 (RR&#x
Alcohol consumption and the risk of rosacea: A systematic review and meta-analysis.
Liu L, Xue Y, Chen Y, Pu Y, Zhang Y, Zhang L · Journal of cosmetic dermatology · 2022
Rosacea is a chronic inflammatory skin disease that affects people's life quality. It has been found to be related to many detrimental factors including ultraviolet exposure. However, the association between alcohol consumption and rosacea has long been debated. To elucidate this association, we conducted a systematic review and meta-analysis. We performed a systematic search of the literature published before February 16, 2021 on PubMed, Embase, and the Cochrane database and used a meta-analytic approach to calculate the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Finally, 14 eligible studies were identified, and alcohol consumption was not found to be a risk factor for rosacea. However, in subgroup analysis, alcohol consumption increased the risk of phymatous rosacea (PhR) and the pooled OR was 4.17 (95% CI = 1.76-9.91). Overall, our study showed that alcohol consumption was a risk factor in phymatous rosacea (PhR). More studies of ros
Structured reviews of the full body of evidence (incl. Cochrane).
Rosacea Core Domain Set for Clinical Trials and Practice: A Consensus Statement.
Dirr MA, Ahmed A, Schlessinger DI, Haq M, Shi V, Koza E · JAMA dermatology · 2024 · n=25
Inconsistent reporting of outcomes in clinical trials of rosacea is impeding and likely preventing accurate data pooling and meta-analyses. There is a need for standardization of outcomes assessed during intervention trials of rosacea. To develop a rosacea core outcome set (COS) based on key domains that are globally relevant and applicable to all demographic groups to be used as a minimum list of outcomes for reporting by rosacea clinical trials, and when appropriate, in clinical practice. A systematic literature review of rosacea clinical trials was conducted. Discrete outcomes were extracted and augmented through discussions and focus groups with key stakeholders. The initial list of 192 outcomes was refined to identify 50 unique outcomes that were rated through the Delphi process Round 1 by 88 panelists (63 physicians from 17 countries and 25 patients with rosacea in the US) on 9-point Likert scale. Based on feedback, an additional 11 outcomes were added in Round 2. Outcomes deem
Treatment of ocular rosacea: a systematic review.
Avraham S, Khaslavsky S, Kashetsky N, Starkey SY, Zaslavsky K, Lam JM · Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2024 · n=275
Rosacea is a common chronic skin disease distributed primarily around the central face. Ocular manifestations of rosacea are poorly studied, and estimates of prevalence vary widely, ranging from 6% to 72% in the rosacea population. Treatment options for ocular rosacea include lid hygiene, topical and oral antibiotics, cyclosporine ophthalmic emulsion, oral vitamin A derivatives, and intense pulsed light; however, a direct comparison of treatment methods for ocular rosacea is lacking. This review aims to compare treatment efficacy and adverse events for different treatment modalities in ocular rosacea. We performed a systematic review by searching Cochrane, MEDLINE and Embase. Title, abstract, full text screening, and data extraction were done in duplicate. Sixty-six articles met the inclusion criteria, representing a total of 1,275 patients. The most effective treatment modalities were topical antimicrobials and oral antibiotics, which achieved complete or partial response in 91%
Natural language processing in dermatology: A systematic literature review and state of the art.
Paganelli A, Spadafora M, Navarrete-Dechent C, Guida S, Pellacani G, Longo C · Journal of the European Academy of Dermatology and Venereology : JEADV · 2024
Natural Language Processing (NLP) is a field of both computational linguistics and artificial intelligence (AI) dedicated to analysis and interpretation of human language. This systematic review aims at exploring all the possible applications of NLP techniques in the dermatological setting. Extensive search on 'natural language processing' and 'dermatology' was performed on MEDLINE and Scopus electronic databases. Only journal articles with full text electronically available and English translation were considered. The PICO (Population, Intervention or exposure, Comparison, Outcome) algorithm was applied to our study protocol. Natural Language Processing (NLP) techniques have been utilized across various dermatological domains, including atopic dermatitis, acne/rosacea, skin infections, non-melanoma skin cancers (NMSCs), melanoma and skincare. There is versatility of NLP in data extraction from diverse sources such as electronic health records (EHRs), social media platforms and onli
Controlled human studies with random assignment.
Min M, Nadora D, Chakkalakal M, Afzal N, Subramanyam C, Gahoonia N · Nutrients · 2024 · n=33
Small intestinal bacterial overgrowth (SIBO) is a common, yet underdiagnosed, gut condition caused by gut dysbiosis. A previous study has shown the potential of herbal therapy, providing equivalent results to rifaximin. The objective of this study was to assess how the use of an oral botanical regimen may modulate the gut microbiome, facial erythema, and intestinal permeability in those with SIBO. This was an open-label prospective study of adults that had lactulose breath test-confirmed SIBO. Participants received a 10-week oral supplementation of a Biocidin liquid tincture and GI Detox+. If participants were found to be non-responsive to treatment after 10 weeks with a persistently positive lactulose breath test, a third oral supplement, Olivirex, was administered for an additional 4 weeks. Lactulose breath tests were administered at baseline, weeks 6, 10, and 14 to assess for SIBO status. A high-resolution photographic analysis system was utilized to analyze changes in facial eryt
Wang B, Huang Y, Tang Y, Zhao Z, Shi W, Jian D · Journal of the American Academy of Dermatology · 2023 · n=97
Patients with refractory erythema of rosacea have limited treatment options. To evaluate the efficacy and safety of a 12-week course of paroxetine for moderate-to-severe erythema of rosacea. In a multicenter, randomized, double-blinded, placebo-controlled trial, patients with refractory erythema of rosacea were randomly assigned (1:1) to receive paroxetine 25 mg daily or placebo for 12 weeks. Overall, 97 patients completed the study (paroxetine: 49; placebo: 48). The primary end point was the proportion of participants achieving Clinical Erythema Assessment success (defined as Clinical Erythema Assessment score of 0, 1, or ≥2-grade improvement from baseline) at week 12; this was significantly greater in the paroxetine group than in the placebo group (42.9% vs 20.8%, P = .02). Some secondary end points were met, such as flushing success with point reductions ≥2 (44.9% vs 25.0%, P = .04) and improvement in overall flushing (2.49 &#
Lazarous MC, Kerdel FA · Drugs of today (Barcelona, Spain : 1998) · 2002
Topical tacrolimus is the first topical immunomodulator of its kind, and its mechanism of action, pharmacokinetics, metabolism and efficacy will be discussed. Multiple studies have supported the safety and efficacy of topical tacrolimus in the treatment of atopic dermatitis in both adults and children. Studies have also suggested that topical tacrolimus may be effective in the treatment of acute contact dermatitis. Although oral administration of tacrolimus proved to be efficacious in psoriasis, results with topical tacrolimus have been disappointing in some studies. Additional reports of success in the use of topical tacrolimus in the treatment of pyoderma gangrenosum show promise, although there is a paucity of randomized, placebo-controlled trials examining its use. It has also been suggested that topical tacrolimus is useful in the treatment of alopecia areata, erosive lichen planus, isolated ichthyosis linearis circumflexa, steroid-induced rosacea, and in the prevention of allogra
Cohort, case-control, and cross-sectional human studies.
The exposomal imprint on rosacea: More than skin deep.
Grafanaki K, Bakoli Sgourou D, Maniatis A, Pasmatzi E · Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
Rosacea is a chronic, inflammatory dermatosis driven by a complex interplay of genetic, environmental and lifestyle factors, collectively known as the exposome. This review explores how intrinsic contributors such as genetic susceptibility, immune dysregulation, microbiome alterations, hormonal influences and psychosocial stress intersect with extrinsic triggers like ultraviolet radiation (UVR), air pollution, dietary factors, and climate variability to shape rosacea pathogenesis. Recent advances in single-cell transcriptomics have identified fibroblasts as key components of inflammatory and vascular pathways in rosacea. Concurrently, discoveries in non-coding RNAs and RNA modifications reveal subtype-specific molecular signatures and novel biomarkers. Mendelian randomization (MR) studies further reveal causal links between rosacea and autoimmune, metabolic and gastrointestinal comorbidities-that rosacea is more than skin deep. The role of the gut-skin axis, particularly involving smal
Proteomic profiling reveals distinct inflammatory and neurogenic endotypes in rosacea.
Huang J, Zhang Y, Yi C, Xiao X, Jian D, Shi W · Journal of the American Academy of Dermatology · 2026 · n=22
Rosacea represents a chronic inflammatory dermatosis with potential systemic manifestations. While neuroimmune dysregulation and systemic inflammation are implicated in its pathogenesis, comprehensive proteomic profiling remains unexplored. To characterize serum proteomic signatures and identify molecular endotypes in rosacea. Using a prospectively characterized clinical cohort, we conducted quantitative proteomic profiling of serum samples from 27 rosacea patients and 25 healthy controls matched for age and sex. Bioinformatic analyses then correlated differentially expressed serum proteins with clinical symptom measures. Analysis identified 490 differentially expressed proteins (431 upregulated, 59 downregulated; log2FC > 1, P < .05). Downregulated proteins were enriched in complement pathways, while upregulated proteins implicated inflammatory (PI3K-Akt, IL-17), metabolic (cholesterol), and neuroregulatory pathways. Cluster analysis revealed 2 distinct endotypes: an inflamma
Liu J, Li Z, Deng Z, Wang Y, Deng F · Ecotoxicology and environmental safety · 2025
The increasing environmental detection of antidepressants such as amitriptyline (AT) has raised toxicological concerns, yet its long-term safety profile remains poorly characterized. We applied an integrative strategy combining phenome-wide association studies (PheWAS), Mendelian randomization (MR), network toxicology, and molecular docking to systematically evaluate potential adverse effects of AT. PheWAS analyses were performed across 784 phenotypes using UK Biobank and FinnGen (R10). Among these, loss-of-function mutations in AT targets SLC6A2 and SLC6A4 showed significant associations after multiple-testing correction with pancreatic cancer and erythematous conditions, respectively. Complementary MR analyses using GTEx v8 tissue-specific cis-expression quantitative trait loci (eQTLs) and multiple autoimmune and inflammatory genome-wide association study (GWAS) datasets demonstrated that elevated expression of SLC6A2 and SLC6A4 conferred protective effects against systemic lupus ery
Public-health agencies: NCCIH, NIH, CDC, NHS.
NHS
The NHS offers information on rosacea, detailing symptoms, causes, and available treatments, alongside advice on self-care and when to seek medical help.
Registered ongoing or completed trials (ClinicalTrials.gov).
n=24 · NCT03079531 · COMPLETED · COMPLETED
This is a study to determine whether secukinumab is a potential therapy for those with papulopustular rosacea. We will observe whether this drug decreases the size and/or amount and severity of the pustules of those who suffer from rosacea.
n=400 · NCT04025801 · UNKNOWN · UNKNOWN
In vivo confocal microscopy (IVCM) has been used in clinical settings for more than 25 years, and is noninvasive, rapid and easily repeatable technique to investigate ocular surface disorders. It enables morphological and quantitative analysis of ocular surface microstructure. \[1-3\] As the technology advances, new IVCM machine, Heidelberg Retinal Tomograph with Rostock Corneal Module (HRT-RCM), was developed. Hardware and software modifications and acquisition techniques continue to expand the applications of the HRT-RCM for quantitative in vivo corneal imaging at the cellular level. The new software can access the corneal nerve more accurate. Here the investigators proposed this Institutional Review Board (IRB) to collect healthy persons and cases of different systematic diseases as well as etiologies of ocular surface diseases.
n=60 · NCT05360251 · UNKNOWN · UNKNOWN
Pulsed dye laser(PDL) and intense pulsed light(IPL) has been widely used in improving rosacea. To compare the efficacy and safety of PDL and IPL configured with different wavelength bands(Delicate Pulsed Light, M22 590, M22 vascular filter) in the treatment of rosacea, we designed a prospective, randomized controlled trial. We hope to make a comparison between PDL and IPL,between broad-spectrum IPL and narrow-spectrum IPL, between single-band IPL and dual-band IPL, and also provide clinical basis for clinicians and patients to develop individualized treatment plans.
Curated cross-source summaries (TRIP Database and similar).
TRIP Database
TRIP Database is a clinical search engine designed to allow users to quickly find high-quality research evidence to support their practice, including information on rosacea from various evidence-based sources.
Conventional treatment for rosacea typically involves topical medications (e.g., metronidazole, azelaic acid, ivermectin, brimonidine) to reduce redness and bumps, and oral antibiotics (e.g., doxycycline) for more severe inflammatory lesions. Laser or light therapy may be used to reduce visible blood vessels and severe redness. Ocular rosacea may be treated with eye drops or oral medications. A de
Latest News
Health Videos
This information is for educational purposes only and not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment of rosacea, especially before starting new supplements or making significant lifestyle changes.
Found something that helped your rosacea?
Help others see what actually works.
Found something that helped your rosacea?
Real-world results help others choose what's worth trying.