Lupus (Systemic Lupus Erythematosus or SLE) is a chronic autoimmune disease where the immune system mistakenly attacks healthy tissues, leading to widespread inflammation and tissue damage in various organs.
Ranked by community outcomes, then evidence grade, Health Voice mentions, and recency.
Why it may help Lupus (SLE): Commonly low and improves outcomes
A pungent root that has been studied for nausea and digestive comfort.
Essential antioxidant vitamin with roles in immunity, collagen synthesis, and (at IV high-dose) integrative oncology.
Why it may help Lupus (SLE): Often deficient in SLE
Why it may help Lupus (SLE): Exercise can improve lupus symptoms by reducing systemic inflammation, enhancing cardiovascular health, and improving muscle strength, which are often compromised in SLE patients.
Why it may help Lupus (SLE): Modest improvement in proteinuria
Why it may help Lupus (SLE): Immunomodulatory
Why it may help Lupus (SLE): Modulates autoimmune flora
Why it may help Lupus (SLE): Antioxidant for autoimmune flares
Why it may help Lupus (SLE): Green tea catechins, particularly EGCG, may modulate immune responses and reduce inflammation in lupus by inhibiting pro-inflammatory cytokines and protecting against oxidative damage.
Why it may help Lupus (SLE): Boswellia may alleviate lupus symptoms by inhibiting pro-inflammatory enzymes like 5-lipoxygenase, thereby reducing the inflammatory cascade characteristic of autoimmune diseases.
Why it may help Lupus (SLE): Omega-3 fatty acids can help manage lupus by reducing systemic inflammation and modulating immune cell activity, thereby mitigating the autoimmune response characteristic of SLE.
Why it may help Lupus (SLE): N-Acetyl Cysteine may benefit lupus by replenishing glutathione, an antioxidant that helps reduce oxidative stress and modulate immune responses, which are dysregulated in SLE.
Magnesium is an essential mineral vital for numerous bodily functions, including energy production, muscle and nerve function, and bone health.
Community outcomes
Self-reported by community members · not medical advice.
Self-reported community outcomes. Not medical advice. Requires at least three reports per remedy to surface.
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Community Discussions
How global health authorities view Lupus (SLE).
Major health organizations like the Mayo Clinic and NIH acknowledge the potential benefits of certain lifestyle modifications and nutritional support in managing lupus symptoms, but emphasize that these should complement, not replace, conventional medical treatment. The NCCIH notes that some complementary health approaches, such as meditation and yoga, may help manage symptoms like pain and fatigue. However, they caution against unproven remedies and stress the importance of discussing all treatments with a healthcare provider, especially regarding potential interactions with lupus medications. There is generally limited strong evidence from large-scale clinical trials for most natural approaches specifically for lupus.
Indexed studies for Lupus (SLE), grouped by source type and quality.
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Cohort, case-control, and cross-sectional human studies.
Targeting type I interferons in systemic lupus erythematous.
Bruera S, Chavula T, Madan R, Agarwal SK · Frontiers in pharmacology · 2022
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with systemic clinical manifestations including, but not limited to, rash, inflammatory arthritis, serositis, glomerulonephritis, and cerebritis. Treatment options for SLE are expanding and the increase in our understanding of the immune pathogenesis is leading to the development of new therapeutics. Autoantibody formation and immune complex formation are important mediators in lupus pathogenesis, but an important role of the type I interferon (IFN) pathway has been identified in SLE patients and mouse models of lupus. These studies have led to the development of therapeutics targeting type I IFN and related pathways for the treatment of certain manifestations of SLE. In the current narrative review, we will discuss the role of type I IFN in SLE pathogenesis and the potential translation of these data into strategies using type I IFN as a biomarker and therapeutic target for patients with SLE.
Qiu CC, Caricchio R, Gallucci S · Frontiers in immunology · 2019
Infections are considered important environmental triggers of autoimmunity and can contribute to autoimmune disease onset and severity. Nucleic acids and the complexes that they form with proteins-including chromatin and ribonucleoproteins-are the main autoantigens in the autoimmune disease systemic lupus erythematosus (SLE). How these nuclear molecules become available to the immune system for recognition, presentation, and targeting is an area of research where complexities remain to be disentangled. In this review, we discuss how bacterial infections participate in the exposure of nuclear autoantigens to the immune system in SLE. Infections can instigate pro-inflammatory cell death programs including pyroptosis and NETosis, induce extracellular release of host nuclear autoantigens, and promote their recognition in an immunogenic context by activating the innate and adaptive immune systems. Moreover, bacterial infections can release bacterial DNA associated with other bacterial molec
Innate Immune Cells' Contribution to Systemic Lupus Erythematosus.
Herrada AA, Escobedo N, Iruretagoyena M, Valenzuela RA, Burgos PI, Cuitino L · Frontiers in immunology · 2019
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, immune complex deposition, and tissue damage in the kidneys, skin, heart and lung. Because of the pathogenic role of antinuclear antibodies and autoreactive T cells in SLE, extensive efforts have been made to demonstrate how B cells act as antibody-producing or as antigen-presenting cells that can prime autoreactive T cell activation. With the discovery of new innate immune cells and inflammatory mediators, innate immunity is emerging as a key player in disease pathologies. Recent work over the last decade has highlighted the importance of innate immune cells and molecules in promoting and potentiating SLE. In this review, we discuss recent evidence of the involvement of different innate immune cells and pathways in the pathogenesis of SLE. We also discuss new therapeutics targets directed against innate immune components as potential novel therap
Public-health agencies: NCCIH, NIH, CDC, NHS.
NHS
The NHS website offers a clear overview of lupus, including its types, symptoms, diagnosis, and available treatments in the UK. It is a trusted resource for general public health information.
Registered ongoing or completed trials (ClinicalTrials.gov).
Clinical Trial of Oral Medication for CTD-ILD Treatment
n=5 · NCT01424033 · TERMINATED · TERMINATED
The first objective of this protocol is to assess the tolerability and safety of N-acetylcysteine (NAC) in patients with connective tissue disease related interstitial lung disease (CTD-ILD).
n=30 · NCT06801119 · RECRUITING · RECRUITING
This is an open lable and single arm study, is designed to evaluate the safety and preliminary efficacy of HN2301 in Autoimmune Disease（AID）
n=18 · NCT06920433 · RECRUITING · RECRUITING
This is an open label, single-site, dose-escalation study in up to 18 participants with relapsed or refractory Systemic lupus erythematosus. This study aims to evaluate the safety and efficacy of the treatment with universal CD19/BCMA CAR T-cells.
Curated cross-source summaries (TRIP Database and similar).
Cochrane Reviews on Systemic lupus erythematosus
Cochrane
Cochrane Library provides systematic reviews and meta-analyses of healthcare interventions relevant to Systemic lupus erythematosus. It is a key resource for evidence-based healthcare decisions.
Search results for 'Green Tea Lupus'
TRIP Database
TRIP Database is a clinical search engine designed to allow users to quickly and easily find high-quality research evidence to support their practice. A search for 'Green Tea Lupus' would aggregate evidence from various sources, including guidelines, systematic reviews, and primary research.
Natural Medicines Database
The Natural Medicines Database offers a comprehensive professional monograph on Black Seed, detailing its uses, effectiveness ratings for various conditions, mechanism of action, adverse effects, and drug interactions. It evaluates the scientific evidence for its use in conditions like rheumatoid arthritis and asthma, but specific strong evidence for Lupus may be limited.
Conventional treatment for lupus typically involves medications such as NSAIDs for pain and inflammation, antimalarials (e.g., hydroxychloroquine) to control disease activity, corticosteroids for acute flares, and immunosuppressants or biologics for more severe cases. Regular monitoring by a rheumatologist is crucial.
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This information is for educational purposes only and does not constitute medical advice. Lupus is a serious condition requiring professional medical diagnosis and management. Always consult with a qualified healthcare provider before making any decisions about your health or treatment, especially i
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