Osteoporosis is a condition characterized by weakened bones, making them brittle and more susceptible to fractures, often due to a loss of bone density.
Ranked by community outcomes, then evidence grade, Health Voice mentions, and recency.
Why it may help Osteoporosis: Critical for calcium absorption
Why it may help Osteoporosis: Required for bone formation
Why it may help Osteoporosis: Vitamin D is crucial for calcium absorption in the gut and its incorporation into bone, directly supporting bone mineralization and reducing bone loss in osteoporosis.
Why it may help Osteoporosis: K2-MK7 activates osteocalcin, a protein that binds calcium to the bone matrix, and matrix Gla protein, which inhibits arterial calcification, thereby promoting bone strength in osteoporosis.
Why it may help Osteoporosis: Calcium is the primary structural component of bone tissue, and adequate intake directly supports bone mineral density and strength, reducing the risk of fractures in osteoporosis.
Why it may help Osteoporosis: Silicon is involved in collagen synthesis and cross-linking, which are essential for the organic matrix of bone, thereby contributing to bone strength and flexibility in osteoporosis.
Why it may help Osteoporosis: Strontium promotes bone formation by stimulating osteoblast activity and inhibits bone resorption by suppressing osteoclast activity, leading to increased bone mineral density in osteoporosis.
Why it may help Osteoporosis: Supports bone turnover balance
Why it may help Osteoporosis: Reduces homocysteine bone risk
Silica is a trace mineral thought to be involved in connective tissue health, including bone, skin, and hair, with ongoing research into its potential benefits.
Manganese is an essential trace mineral vital for bone health, metabolism, and antioxidant function.
Why it may help Osteoporosis: Weight-bearing and resistance exercise stimulate osteoblast activity and increase bone mineral density, directly counteracting bone loss and reducing fracture risk in osteoporosis.
Why it may help Osteoporosis: Required for bone mineralization
Why it may help Osteoporosis: Improves calcium retention
Why it may help Osteoporosis: Magnesium contributes to bone mineral density by influencing calcium metabolism and parathyroid hormone regulation, which are crucial for preventing bone loss in osteoporosis.
Why it may help Osteoporosis: Copper is essential for the activity of lysyl oxidase, an enzyme vital for collagen cross-linking and the structural integrity of bone matrix, thereby supporting bone health in osteoporosis.
Blackstrap molasses is a nutrient-dense byproduct of sugar refining, rich in minerals like iron, calcium, and magnesium, traditionally used as a dietary supplement for general health and specific deficiencies.
Community outcomes
Self-reported by community members · not medical advice.
Self-reported community outcomes. Not medical advice. Requires at least three reports per remedy to surface.
Community outcome data is still being collected for this ailment.
Be the first to share your experience →As more members share outcomes, RemedyAtlas will show which remedies helped people with similar conditions, symptoms, goals, and lab patterns.
Structured experience reports from people managing this condition. Not medical advice.
You can share without an account — we'll send a one-time code to verify your email. Or sign in.
Loading posts…
Community Discussions
How global health authorities view Osteoporosis.
The World Health Organization (WHO) and National Institutes of Health (NIH) emphasize the importance of adequate calcium and vitamin D intake, along with regular weight-bearing exercise, for bone health and osteoporosis prevention. The Mayo Clinic also highlights these foundational lifestyle factors. While some traditional remedies are used for bone health, major international bodies generally prioritize evidence-based nutritional and exercise interventions and conventional medical treatments for established osteoporosis. The NCCIH acknowledges ongoing research into complementary health approaches but advises caution and consultation with healthcare providers.
Indexed studies for Osteoporosis, grouped by source type and quality.
Filter by source type
Pooled analyses across multiple human trials.
de Souza MM, Moraes Dantas RL, Leão Durães V, Defante MLR, Mendes TB · Journal of general internal medicine · 2024 · n=899
Although a well-established component of bone metabolism, the efficacy and safety of vitamin D supplementation for the prevention of fractures in elderly healthy individuals is still unclear. To perform a meta-analysis comparing vitamin D supplementation with placebo and its contributions on fracture incidence. This meta-analysis was registered in the International Prospective Register of Systematic Reviews (PROSPERO), under protocol CRD42023484979. We systematically searched PubMed, Embase, and Cochrane Central databases from inception to November 2023 for randomized controlled trials (RCTs) comparing vitamin D supplementation versus placebo in individuals with 60 years of age or more and without bone related medical conditions such as cancer and osteoporosis. Seven RCTs with 71,899 patients were included, of whom 36,822 (51.2%) were women. There was no significant difference in total fracture incidence (RR 1.03; 95% CI 0.93-1.14; p = 0.56; I2 = 58%
Wang F, Wei W, Liu PJ · Frontiers in endocrinology · 2024
The beneficial effects of probiotic supplementation on bone health in postmenopausal women require further validation. This study systematically reviewed and conducted a meta-analysis of randomized controlled trials (RCTs) to assess the relationship between probiotic supplementation and changes in bone mineral density (BMD) and bone turnover markers (BTMs) among postmenopausal women. A systematic search was conducted across four databases to retrieve data on lumbar spine BMD, hip BMD, collagen type 1 cross-linked C-telopeptide (CTX), receptor activator of nuclear factor-κB ligand (RANKL), osteocalcin (OC), osteoprotegerin (OPG), N-terminal propeptide of type 1 procollagen (P1NP), and bone-specific alkaline phosphatase (BALP) in postmenopausal women. Eligible RCTs were quantitatively analyzed using random-effects meta-analyses. Additional analyses, including subgroup, sensitivity, and meta-regression analyses, were performed. Twelve RCTs involving 1183 postmenopausal women were
Liu C , Kuang X , Li K , Guo X , Deng Q , Li D · Food & function · 2020
The aim of the present study was to explore whether combined calcium and vitamin D supplementation is beneficial for osteoporosis in postmenopausal women. We searched the PubMed, Cochrane library, Web of science and Embase databases and reference lists of eligible articles up to Feb, 2020. Randomized controlled trials (RCTs) evaluating the effect of combined calcium and vitamin D on osteoporosis in postmenopausal women were included in the present study. Combined calcium and vitamin D significantly increased total bone mineral density (BMD) (standard mean differences (SMD) = 0.537; 95% confidence interval (CI): 0.227 to 0.847), lumbar spine BMD (SMD = 0.233; 95% CI: 0.073 to 0.392; P < 0.001), arms BMD (SMD = 0.464; 95% CI: 0.186 to 0.741) and femoral neck BMD (SMD = 0.187; 95% CI: 0.010 to 0.364). It also significantly reduced the incidence of hip fracture (RR = 0.864; 95% CI: 0.763 to 0.979). Subgroup analysis showed that combined calcium and vitamin D significantly increased fe
Structured reviews of the full body of evidence (incl. Cochrane).
Calcium and vitamin D for increasing bone mineral density in premenopausal women.
Méndez-Sánchez L, Clark P, Winzenberg TM, Tugwell P, Correa-Burrows P, Costello R · The Cochrane database of systematic reviews · 2023 · n=941
Osteoporosis is a condition where bones become fragile due to low bone density and impaired bone quality. This results in fractures that lead to higher morbidity and reduced quality of life. Osteoporosis is considered a major public health concern worldwide. For this reason, preventive measurements need to be addressed throughout the life course. Exercise and a healthy diet are among the lifestyle factors that can help prevent the disease, the latter including intake of key micronutrients for bone, such as calcium and vitamin D. The evidence on whether supplementation with calcium and vitamin D improves bone mineral density (BMD) in premenopausal women is still inconclusive. In this age group, bone accrual is considered to be the goal of supplementation, so BMD is relevant for the future stages of life. To evaluate the benefits and harms of calcium and vitamin D supplementation, alone or in combination, to increase the BMD, reduce fractures, and report the potential adverse events in
Does vitamin D have an effect on osseointegration of dental implants? A systematic review.
Werny JG, Sagheb K, Diaz L, Kämmerer PW, Al-Nawas B, Schiegnitz E · International journal of implant dentistry · 2022
The aim of this study was to systematically review the available evidence to evaluate the efficacy of vitamin D supplementation or vitamin D depletion on the osseointegration of implants in animals and humans. The focus questions addressed were "Do vitamin D deficient subjects treated with (dental) implants have an inferior osseointegration than subjects with adequate serum vitamin D level?" and "Do vitamin D supplemented subjects treated with (dental) implants have a superior osseointegration than subjects with adequate serum vitamin D level?" Humans and animals were considered as subjects in this study. Databases were searched from 1969 up to and including March 2021 using different combination of the following terms: "implant", "bone to implant contact", "vitamin D" and "osseointegration". Letters to the editor, historic reviews, commentaries and articles published in languages other than English and German were excluded. The pattern of the present systematic review was customize t
Vitamin D requirements in infancy: a systematic review.
Mimouni FB, Huber-Yaron A, Cohen S · Current opinion in clinical nutrition and metabolic care · 2017
New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature. Randomized controlled trials published since 2009 that related to vitamin D doses in infancy were reviewed. They do not provide any additional evidence that larger, more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose, affect any significant outcome. Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects. There are still many unanswered questions left, in particular whether or not more 'generous' amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis, allergies, or cancer.
Recommendations from medical societies (NICE, AHA, ADA, ACG, Endocrine Society…).
The Endocrine Society
This guideline provides evidence-based recommendations for the pharmacological management of osteoporosis in postmenopausal women. It helps clinicians in choosing appropriate treatments.
Treatment of Osteoporosis in Men: An Endocrine Society Clinical Practice Guideline
The Endocrine Society · Strength: Strong recommendation
This clinical practice guideline from the Endocrine Society provides evidence-based recommendations for the diagnosis and treatment of osteoporosis specifically in men.
Osteoporosis: assessing the risk of fragility fracture
NICE
This guideline covers assessing the risk of fragility fracture in primary care and making a referral for further assessment. It aims to identify people at high risk of osteoporotic fracture to enable timely intervention.
Controlled human studies with random assignment.
Moore AE, Dulnoan D, Voong K, Ayis S, Mangelis A, Gorska R · Archives of osteoporosis · 2023 · n=105
This study assessed whether vitamin K, given with oral bisphosphonate, calcium and/or vitamin D has an additive effect on fracture risk in post-menopausal women with osteoporosis. No difference in bone density or bone turnover was observed although vitamin K1 supplementation led to a modest effect on parameters of hip geometry. Some clinical studies have suggested that vitamin K prevents bone loss and may improve fracture risk. The aim was to assess whether vitamin K supplementation has an additive effect on bone mineral density (BMD), hip geometry and bone turnover markers (BTMs) in post-menopausal women with osteoporosis (PMO) and sub-optimum vitamin K status receiving bisphosphonate, calcium and/or vitamin D treatment. We conducted a trial in 105 women aged 68.7[12.3] years with PMO and serum vitamin K1 ≤ 0.4 µg/L. They were randomised to 3 treatment arms; vitamin K1 (1 mg/day) arm, vitamin K2 arm (MK-4; 45 mg/day) or placebo for 18 mo
Burt LA, Billington EO, Rose MS, Raymond DA, Hanley DA, Boyd SK · JAMA · 2019 · n=311
Few studies have assessed the effects of daily vitamin D doses at or above the tolerable upper intake level for 12 months or greater, yet 3% of US adults report vitamin D intakes of at least 4000 IU per day. To assess the dose-dependent effect of vitamin D supplementation on volumetric bone mineral density (BMD) and strength. Three-year, double-blind, randomized clinical trial conducted in a single center in Calgary, Canada, from August 2013 to December 2017, including 311 community-dwelling healthy adults without osteoporosis, aged 55 to 70 years, with baseline levels of 25-hydroxyvitamin D (25[OH]D) of 30 to 125 nmol/L. Daily doses of vitamin D3 for 3 years at 400 IU (n = 109), 4000 IU (n = 100), or 10 000 IU (n = 102). Calcium supplementation was provided to participants with dietary intake of less than 1200 mg per day. Co-primary outcomes were total volumetric BMD at radius and tibia, assessed with high resolution peripheral quan
König D, Oesser S, Scharla S, Zdzieblik D, Gollhofer A · Nutrients · 2018 · n=66
Introduction: Investigations in rodents as well as in vitro experiments have suggested an anabolic influence of specific collagen peptides (SCP) on bone formation and bone mineral density (BMD). The goal of the study was to investigate the effect of 12-month daily oral administration of 5 g SCP vs. placebo (CG: control group) on BMD in postmenopausal women with primary, age-related reduction in BMD. Methods: 131 women were enrolled in this randomized, placebo-controlled double-blinded investigation. The primary endpoint was the change in BMD of the femoral neck and the spine after 12 months. In addition, plasma levels of bone markers-amino-terminal propeptide of type I collagen (P1NP) and C-telopeptide of type I collagen (CTX 1)-were analysed. Results: A total of 102 women completed the study, but all subjects were included in the intention-to-treat (ITT) analysis (age 64.3 ± 7.2 years; Body Mass Index, BMI 23.6 ± 3.6 kg/m²; T-score spine -2.4 ± 0.6; T-score femoral
Cohort, case-control, and cross-sectional human studies.
Migliorini F, Maffulli N, Colarossi G, Filippelli A, Memminger M, Conti V · European journal of medical research · 2025 · n=397
The present systematic review investigates whether different doses of vitamin D and calcium supplementation in women with postmenopausal osteoporosis undergoing antiresorptive therapy have an association with BMD (spine, hip, femur neck), serum markers of osteoporosis (bone-ALP, NTX, CTX), the rate of pathological vertebral and non-vertebral fractures, adverse events, and mortality. This systematic review was conducted according to the PRISMA 2020 guidelines. PubMed, Google Scholar, Embase, and Scopus databases were accessed in September 2024. All randomised clinical trials (RCTs) comparing two or more treatments for postmenopausal osteoporosis supplemented with vitamin D and/or calcium were accessed. Only studies that indicated daily vitamin D and/or calcium supplementation doses were accessed. Data from 37 RCTs (43,397 patients) were retrieved. Patients received a mean of 833.6 ± 224.0 mg and 92.8 ± 228.7 UI of calcium and vitamin D suppleme
The association between dietary mineral intake and bone mineral density: a cross-sectional study.
Wei M, Wei J, Huang S · Journal of health, population, and nutrition · 2025
Minerals are essential for maintaining bone health; however, the relationship between specific mineral intakes and bone mineral density (BMD) remains insufficiently understood. This study aims to examine the associations between the intakes of dietary minerals, including calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe), zinc (Zn), copper (Cu), sodium (Na), potassium (K), and selenium (Se), and BMD. A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES). Multivariate weighted generalized linear regression and smooth curve fitting were applied to evaluate the associations between dietary mineral intakes and BMD. Furthermore, subgroup analyses and interaction tests were performed to assess the consistency of these associations across different individual characteristics. A total of 11,520 representative adult participants were included in the study. Tertile-based categorical analysis revealed significant positive correl
Cianferotti L, Bifolco G, Caffarelli C, Mazziotti G, Migliaccio S, Napoli N · Nutrients · 2024
Hip fractures are a major health issue considerably impacting patients' quality of life and well-being. This is particularly evident in elderly subjects, in which the decline in bone and muscle mass coexists and predisposes individuals to fall and fracture. Among interventions to be implemented in hip fractured patients, the assessment and management of nutritional status is pivotal, particularly in subjects older than 65. Nutrition plays a central role in both primary and secondary preventions of fracture. An adequate protein intake improves muscle mass and strength and the intestinal absorption of calcium. Other nutrients with recognized beneficial effects on bone health are calcium, vitamins D, K, and C, potassium, magnesium, folate, and carotenoids. With reference to calcium, results from longitudinal studies showed that the consumption of dairy foods has a protective role against fractures. Moreover, the most recent systematic reviews and meta-analyses and one umbrella review demo
Public-health agencies: NCCIH, NIH, CDC, NHS.
NHS
The NHS provides clear and concise information about osteoporosis, covering symptoms, causes, diagnosis, treatment, and living with the condition. It is a key source of health advice for the UK public.
Registered ongoing or completed trials (ClinicalTrials.gov).
n=2456 · NCT00145327 · COMPLETED · COMPLETED
This extension study is designed to assess the long term safety and efficacy of zoledronic acid in postmenopausal women with osteoporosis who have participated in the CZOL446H2301 (NCT00049829): HORIZON Pivotal Fracture Trial. This extension study began after the 3-year core study ended. Baseline is the same as Year 3.
n=100 · NCT00957606 · UNKNOWN · UNKNOWN
The purpose of this study is * to determine the rate of osteoporosis among patients with advanced prostate cancer. * to propose an algorithm for early detection of patients with advanced prostate cancer who are at risk of developing osteoporosis.
Improving Management of Patients at High Risk for Osteoporotic Fractures
n=4266 · NCT00139438 · COMPLETED · COMPLETED
The purpose of this study is to assess the impact of disease management interventions on percent receiving a bone densitometry test and percent appropriately prescribed a medication for osteoporosis.
Curated cross-source summaries (TRIP Database and similar).
Cochrane reviews on osteoporosis
Cochrane
Cochrane provides a collection of systematic reviews and meta-analyses on various interventions and aspects related to osteoporosis. It is a key source for evidence-based healthcare decisions.
Cochrane Library: Osteoporosis
Cochrane
The Cochrane Library provides high-quality, independent evidence to inform healthcare decision-making, including systematic reviews related to osteoporosis. It is a critical resource for evidence-based medicine.
Conventional treatment for osteoporosis often involves prescription medications, such as bisphosphonates, hormone therapy, or other bone-building drugs, to slow bone loss or promote bone formation. These treatments are typically prescribed based on individual risk factors and bone density measurements.
Latest News
Health Videos
This information is for educational purposes only and not a substitute for professional medical advice. Always consult with a qualified healthcare provider before making any decisions about your health or treatment plan, especially if you have osteoporosis or are at risk.
Found something that helped your osteoporosis?
Help others see what actually works.
Found something that helped your osteoporosis?
Real-world results help others choose what's worth trying.