Curcumin, the active compound in turmeric, is recognized for its potential anti-inflammatory and antioxidant properties, with ongoing research exploring its health benefits.
Last reviewed June 17, 2026 · AI-assisted, human-reviewed
Curcumin, the active compound in turmeric, has been investigated for its potential to alleviate symptoms and progression of endometriosis due to its anti-inflammatory and antioxidant properties. Research suggests it may influence several pathways involved in the development and maintenance of endometrial lesions.
Quick answer
What it is: Curcumin, the active compound in turmeric, has been investigated for its potential to alleviate symptoms and progression of endometriosis due to its anti-inflammatory and antioxidant properties.
Given the absence of specific PubMed studies provided for this request, the evidence grade for curcumin's efficacy in treating specific ailments is considered preliminary. General knowledge suggests that much of the existing research consists of in vitro studies, animal models, and a limited number of human clinical trials, often with small sample sizes or methodological limitations. Therefore, strong clinical evidence for many of its purported benefits is still developing.
Last reviewed · Jun 2026
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Commonly Combined With
Other remedies frequently used alongside this one — from curated relationships, community reports, and shared protocols.
Community signal breakdown
Where this remedy is being discussed across the web and community.
Dietary protocols studied for the conditions this remedy is associated with.
Anti-Inflammatory Diet
A whole-foods pattern designed to lower chronic, low-grade inflammation by emphasizing omega-3s, polyphenols, fiber, and minimizing ultra-processed foods, sugar, and seed oils.
The anti-inflammatory diet is not a single protocol but a synthesis of the patterns most consistently linked to lower inflammatory markers (CRP, IL-6, TNF-alpha) in human studies — Mediterranean-style eating, oily fish, abundant polyphenols, and low intake of ultra-processed foods, refined sugar, industrial seed oils, and excessive alcohol.
Foods to emphasize
Fatty fish 2–3x/week (salmon, sardines, mackerel, herring)
Extra-virgin olive oil
Berries, cherries, and other deeply colored fruit
Dark leafy greens and cruciferous vegetables
Turmeric, ginger, and culinary herbs
Green tea
Nuts (especially walnuts) and seeds (flax, chia)
Legumes and whole grains
Dark chocolate (≥70% cocoa) in moderation
Foods to avoid
Sugar-sweetened beverages and refined sugar
Ultra-processed snacks and ready meals
Industrial seed oils used at high heat (soybean, corn, sunflower, cottonseed)
Processed and cured meats
Refined flour products
Excess alcohol
Key principles
Cook with olive oil, finish with extra-virgin olive oil
Aim for 25–35 g of fiber per day from whole foods
Eat the rainbow — color diversity ~ polyphenol diversity
Limit added sugar to <25 g/day
Typical duration: A long-term eating pattern.
Why it may help
Joint Pain: Reductions in CRP and IL-6 on anti-inflammatory patterns translate to less pain and stiffness in arthritis trials.
Safe and flexible. Can be combined with Mediterranean, vegetarian, or plant-forward patterns.
Vegan Diet
A fully plant-based eating pattern that excludes all animal products — meat, fish, dairy, eggs, and honey.
A whole-food vegan diet emphasizes vegetables, fruit, legumes, whole grains, nuts, and seeds. It has been associated with improvements in body weight, blood lipids, and glycemic control, and is being studied for autoimmune and inflammatory conditions. It requires deliberate planning for vitamin B12, vitamin D, omega-3 (EPA/DHA), iodine, iron, zinc, and (sometimes) calcium.
Nuts and seeds (especially walnuts, chia, flax, hemp)
Fortified plant milks and nutritional yeast
Algae-based EPA/DHA supplement
Vitamin B12 supplement (non-negotiable)
Foods to avoid
Refined grains and sugar as the bulk of meals
Heavily processed vegan junk foods
Coconut and palm oils in excess
Key principles
B12 supplementation is required, not optional
Include a reliable iodine source (iodized salt or seaweed in moderation)
Get vitamin D from sun and/or a supplement
Combine grains and legumes across the day for complete protein
Choose calcium-fortified plant milk if not eating leafy greens daily
Typical duration: A long-term eating pattern.
Why it may help
Joint Pain: Several RCTs report meaningful improvements in pain, swelling, and CRP in rheumatoid arthritis patients on whole-food vegan diets.
Vegan diets can be excellent or deficient — quality depends on planning. Pregnant, breastfeeding, and growing children on vegan diets should be followed by a registered dietitian.
Vegetarian Diet
A plant-based eating pattern that excludes meat, poultry, and fish but typically allows eggs and/or dairy.
Vegetarian diets range from lacto-ovo (includes eggs and dairy) to lacto (dairy only) and ovo (eggs only). Done well, they are associated with lower rates of cardiovascular disease, type 2 diabetes, and some cancers. Done poorly, they can be high in refined grains and low in key nutrients (B12, iron, omega-3s, zinc).
Foods to emphasize
Legumes (lentils, chickpeas, beans, tofu, tempeh)
Whole grains (oats, quinoa, brown rice, whole wheat)
Vegetables and fruit, daily and varied
Nuts and seeds (almonds, walnuts, chia, flax, hemp)
The Autoimmune Protocol removes foods commonly implicated in immune activation and gut permeability — grains, legumes, dairy, eggs, nightshade vegetables, nuts, seeds, refined sugar, alcohol, and additives — for a 30–90 day elimination, followed by careful one-at-a-time reintroduction. It is most studied in Hashimoto's thyroiditis and inflammatory bowel disease.
Foods to emphasize
Quality meat, poultry, and seafood (especially wild-caught fatty fish)
Organ meats once or twice weekly
A wide variety of non-nightshade vegetables and leafy greens
Nuts and seeds (including seed-based spices like cumin, coriander)
Refined sugar and sweeteners
Alcohol
NSAIDs and food additives where possible
Key principles
Pair the elimination with sleep, stress management, and movement
Track symptoms in a journal during reintroductions
Reintroduce one food every 5–7 days and watch for symptom changes
Most people do NOT need to stay strict long-term — the goal is a personalized maintenance diet
Typical duration: 30–90 day strict elimination, then a structured staged reintroduction over weeks to months.
Why it may help
Joint Pain: Eliminates nightshades, gluten, and dairy — common reported triggers — to identify dietary contributors to inflammatory joint pain.
AIP is restrictive and best done with a practitioner familiar with the protocol, especially when active autoimmune disease is involved or in pregnancy/lactation.
Carnivore Diet
An all-animal-foods elimination diet consisting of meat, fish, eggs, and (optionally) dairy, with zero plant foods.
The carnivore diet is the most aggressive elimination diet — it removes every plant food (and therefore every fiber, lectin, oxalate, gluten, and FODMAP source) to isolate animal-food tolerance. Proponents use it primarily as a short-term diagnostic elimination to surface food triggers in autoimmune, gut, and inflammatory conditions. Long-term safety data is limited and observational.
Foods to emphasize
Ruminant meat (beef, lamb, bison) — emphasized for nutrient density
Pasture-raised eggs
Fatty fish (salmon, sardines)
Organ meats (liver, kidney) once or twice weekly
Bone broth and bone marrow
Animal fats (tallow, butter, ghee)
Salt to taste
Optional: aged hard cheeses, heavy cream
Foods to avoid
All grains, legumes, and seeds
All vegetables and fruit
Nuts and plant oils
Sugar and sweeteners
Most processed foods
Alcohol
Key principles
Eat to satiety — no calorie counting
Salt food liberally to maintain electrolytes
Prioritize fattier cuts over lean meats
Reintroduce foods one at a time after the elimination window to identify triggers
Best tracked with a clinician given the radical nature of the change
Typical duration: Typically run as a 30–90 day elimination, then food reintroductions one at a time.
Why it may help
Joint Pain: Used as an elimination diet to surface plant-based food triggers (nightshades, lectins) reported by some people to drive joint pain. No clinical trials.
Long-term effects on cardiovascular markers, bone health, and the gut microbiome are not well established. Avoid in chronic kidney disease, gout flares, or active eating disorders without medical supervision.
Linked nutrient deficiencies
Vitamin and mineral deficiencies commonly associated with the conditions this remedy may support.
Selenium
Trace mineral
Essential for thyroid hormone metabolism and antioxidant defense (glutathione peroxidase).
Selenium reduces TPO antibodies in Hashimoto's and supports T4→T3 conversion. Deficiency is implicated in thyroid autoimmunity and viral susceptibility.
Low vitamin D status is one of the most widespread deficiencies globally and has been linked to autoimmune disease activity (Hashimoto's, MS), mood disorders, recurrent infections, and poor skin barrier function.
Common symptoms
Fatigue
Low mood
Frequent infections
Bone or muscle aches
Hair thinning
Food sources
Fatty fish (salmon, sardines)
Egg yolks
Cod liver oil
UV-exposed mushrooms
Fortified dairy
Lab markers to discuss
25-hydroxyvitamin D (target 40–60 ng/mL per most functional ranges)
Reference intake: Adults 600–800 IU/day RDA; functional medicine often targets 2,000–5,000 IU/day with monitoring.
Supplementation notes: Take with a fat-containing meal. Pair with vitamin K2 (MK-7) when supplementing higher doses long-term.
Why it matters here
Hyperthyroidism: Low vitamin D is associated with Graves' disease activity.
Joint Pain: Deficiency is associated with chronic widespread pain and osteoarthritis progression.
Magnesium
Mineral
Cofactor in over 300 enzymatic reactions; crucial for nervous system calm, sleep, and muscle function.
An estimated 50% of adults consume below the EAR. Low magnesium is linked to insomnia, anxiety, migraines, muscle tension, and poor blood sugar regulation.
Common symptoms
Muscle cramps or twitches
Poor sleep
Anxiety, irritability
Headaches/migraines
Constipation
Food sources
Pumpkin seeds
Dark leafy greens
Almonds and cashews
Dark chocolate (85%+)
Black beans
Avocado
Lab markers to discuss
RBC magnesium (more sensitive than serum)
Serum magnesium
Reference intake: 310–420 mg/day RDA depending on age and sex.
Supplementation notes: Glycinate for sleep/anxiety, citrate for constipation, threonate for cognitive/brain effects. Avoid magnesium oxide (poorly absorbed).
Why it matters here
Joint Pain: Supports muscle relaxation and reduces secondary pain.
Curcumin demonstrates anti-inflammatory effects by inhibiting NF-κB signaling, a key regulator of inflammatory responses, and by reducing the production of pro-inflammatory cytokines such as TNF-α and IL-6. It also modulates angiogenesis by downregulating VEGF expression, potentially limiting the blood supply to endometrial implants, and induces apoptosis in aberrant endometrial cells.
How it works in more detail
Curcumin's potential mechanisms of action are complex and involve interactions with various molecular targets. It has been observed to inhibit the activity of several inflammatory mediators, including NF-κB, COX-2, and LOX. Additionally, curcumin may influence cytokine production, such as TNF-α, IL-1β, and IL-6. Its antioxidant properties are attributed to its ability to scavenge free radicals and enhance the activity of endogenous antioxidant enzymes like superoxide dismutase and glutathione peroxidase. These actions collectively contribute to its observed anti-inflammatory and antioxidant effects.
How to use
Always consult a qualified clinician.
Editorial guidance
Suggested dosage
400-1200 mg per day of standardized curcumin extract, often in formulations designed for enhanced bioavailability, taken with food.
Research dosage range
Research studies have used a wide range of dosages, from 80 mg to 12,000 mg per day, depending on the condition being studied and the formulation used.
Typical onset
The onset of effects can vary widely depending on the condition, dosage, and individual, but some effects may be observed within weeks of consistent use.
Typical forms
Capsule, Tablet, Powder, Liquid extract
Quality markers
Look for supplements standardized to contain a high percentage of curcuminoids (e.g., 95%). Products that include bioavailability enhancers like piperine (black pepper extract) or are formulated with liposomes or nanoparticles may offer improved absorption.
Medication interactions
Anticoagulants (blood thinners)
Antiplatelet drugs
NSAIDs
Diabetes medications
Stomach acid reducers (e.g., PPIs, H2 blockers)
Avoid if
Gallstones or bile duct obstruction
Bleeding disorders
Pregnant or breastfeeding (high doses)
Planning surgery
Pregnancy / lactation
Limited research exists on the safety of high-dose curcumin supplements during pregnancy and lactation. It is generally advised to avoid supplemental doses beyond those found in food, or to consult a healthcare professional.
Community tips
No community tips yet — be the first to share what worked for you.
Suggested dosage
400-1200 mg per day of standardized curcumin extract, often in formulations designed for enhanced bioavailability, taken with food.
General guidance — discuss specifics with a clinician.
Turmeric, from which curcumin is derived, has been a staple in Ayurvedic and Traditional Chinese Medicine for thousands of years. It has been traditionally used for a wide array of conditions, including inflammatory diseases, digestive issues, skin conditions, and wound healing, and as a general tonic.
Safety
Safety warnings
Generally well-tolerated, but high doses may lead to gastrointestinal upset, nausea, or diarrhea. It may also thin the blood.
Avoid if
Gallstones or bile duct obstruction
Bleeding disorders
Pregnant or breastfeeding (high doses)
Planning surgery
Medication interactions
Anticoagulants (blood thinners)
Antiplatelet drugs
NSAIDs
Diabetes medications
Stomach acid reducers (e.g., PPIs, H2 blockers)
Reported side effects
Gastrointestinal upset
Diarrhea
Nausea
Headache
Skin rash (rare)
Pregnancy & lactation
Limited research exists on the safety of high-dose curcumin supplements during pregnancy and lactation. It is generally advised to avoid supplemental doses beyond those found in food, or to consult a healthcare professional.
General guidance — discuss specifics with a clinician.
Evidence ecosystem
Scientific literature, clinical guidance, government sources, ongoing research, traditional use, and lived experience — grouped by source type and quality.
Overall grade (B)
Given the absence of specific PubMed studies provided for this request, the evidence grade for curcumin's efficacy in treating specific ailments is considered preliminary. General knowledge suggests that much of the existing research consists of in vitro studies, animal models, and a limited number of human clinical trials, often with small sample sizes or methodological limitations. Therefore, strong clinical evidence for many of its purported benefits is still developing.
Zhao G, Fan Y, Li R, Huang Y, Li W, Zhao Y · Reproductive biology and endocrinology : RB&E · 2025 · n=501
Nutritional supplements are known to ameliorate polycystic ovary syndrome (PCOS) and have been shown to modulate endocrine and metabolic markers, oxidative stress markers and inflammatory biomarkers in patients with PCOS. A variety of nutritional supplements have been applied in clinics, but a more comprehensive ranking of their efficacy has not yet been investigated.
To assess the comparative effectiveness of nutritional supplements in women with PCOS.
A systematic search was conducted across PubMed, EMBASE, Web of Science, and the Cochrane Library for randomized controlled trials (RCTs) that met the inclusion criteria up to October 12, 2023. We performed a network meta-analysis (NMA) to evaluate the effectiveness of various nutritional supplements on different indicators of PCOS by synthesizing both direct and indirect evidence from the trials.
Seventy-nine RCTs involving 5,501 participants were enrolled in the NMA. It suggested that chromium was notably effective in improving fol
Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W · Frontiers in immunology · 2022
To evaluate the randomized controlled trials (RCTs) of Curcumin and Curcuma longa Extract in the treatment of autoimmune diseases.
Databases such as Embase, Web of Science, PubMed and The Cochrane Library were searched from the database establishment to February 2022 to collect RCTs of Curcumin and Curcuma longa Extract in the treatment of autoimmune diseases. Then the literature was screened and the data were extracted. Meta-analysis was performed using RevMan 5.3 software.
A total of 34 records were included, involving 31 RCTs and 10 types of autoimmune disease. Among them, ankylosing spondylitis (AS) involves one RCT, Behcet 's disease (BD) involves one RCT, Crohn 's disease involves two RCTs, multiple sclerosis (MS) involves two RCTs, oral lichen planus involves six RCTs, psoriasis involves two RCTs, rheumatoid arthritis (RA) involves five RCTs, systemic lupus erythematosus (SLE) involves two RCTs, arteritis involves one RCT, ulcerative colitis (UC) involves nine RCTs. Among them
Yang K, Chen J, Zhang T, Yuan X, Ge A, Wang S · Frontiers in immunology · 2022 · n=173
Dietary polyphenol treatment of non-alcoholic fatty liver disease (NAFLD) is a novel direction, and the existing clinical studies have little effective evidence for its therapeutic effect, and some studies have inconsistent results. The effectiveness of dietary polyphenols in the treatment of NAFLD is still controversial. The aim of this study was to evaluate the therapeutic efficacy of oral dietary polyphenols in patients with NAFLD.
The literature (both Chinese and English) published before 30 April 2022 in PubMed, Cochrane, Medline, CNKI, and other databases on the treatment of NAFLD with dietary polyphenols was searched. Manual screening, quality assessment, and data extraction of search results were conducted strictly according to the inclusion and exclusion criteria. RevMan 5.3 software was used to perform the meta-analysis.
The RCTs included in this study involved dietary supplementation with eight polyphenols (curcumin, resveratrol, naringenin, anthocyanin, hesperidin, catech
Meta-AnalysisPubMedVery High Quality
Systematic Reviews(6)
Structured reviews of the full body of evidence (incl. Cochrane).
Chalupczak NV, Lio PA · Archives of dermatological research · 2024
Despite recent advancements in psoriasis treatment, challenges in management persist. Recently, there has been a rising interest amongst patients in complementary and alternative medicines (CAM), driven by the desire for more natural, holistic approaches and dissatisfaction with conventional treatments. Up to 41% of patients with psoriasis reported using alternative therapies and 39.5% use complementary therapies (Murphy EC, Nussbaum D, Prussick R, Friedman AJ (2019) Use of complementary and alternative medicine by patients with psoriasis. J Am Acad Dermatol 81:280-283). Despite their rapidly growing prevalence, literature on CAM therapies for psoriasis is lacking, making their recommendation difficult. Since the last systematic review on this topic published in 2018, evidence for new alternative therapies has emerged, promoting a further investigation of their efficacy (Gamret AC, Price A, Fertig RM, Lev-Tov H, Nichols AJ (2018) Complementary and Alternative Medicine Therapies for Pso
St Pierre K, Cashmore BA, Bolignano D, Zoccali C, Ruospo M, Craig JC · The Cochrane database of systematic reviews · 2024 · n=8016
Autosomal dominant polycystic kidney disease (ADPKD) is the leading inherited cause of kidney disease. Clinical management has historically focused on symptom control and reducing associated complications. Improved understanding of the molecular and cellular mechanisms involved in kidney cyst growth and disease progression has resulted in new pharmaceutical agents targeting disease pathogenesis and preventing disease progression. However, the role of disease-modifying agents for all people with ADPKD is unclear. This is an update of a review first published in 2015.
We aimed to evaluate the benefits and harms of interventions to prevent the progression of ADPKD and the safety based on patient-important endpoints, defined by the Standardised Outcomes in NephroloGy-Polycystic Kidney Disease (SONG-PKD) core outcome set, and general and specific adverse effects.
We searched the Cochrane Kidney and Transplants Register of Studies up to 13 August 2024 through contact with the Information S
Ranneh Y, Bedir AS, Abu-Elsaoud AM, Al Raish S · Nutrients · 2024
Non-alcoholic fatty liver disease (NAFLD) has recently emerged as a challenging metabolic disorder with a strong emphasis on its prevention and management. Polyphenols, a group of naturally occurring plant compounds, have been associated with a decreased risk of various metabolic disorders related to NAFLD. The current systematic review aims to critically assess evidence about the ameliorative effect of polyphenol supplementation on NAFLD patients. A PRISMA systematic search appraisal was conducted in PubMed, Scopus, Web of Science Core Collection, and all relevant studies published prior to April 2024 and met the inclusion criteria were included. Twenty-nine randomized clinical trials (RCTs) comprised 1840 NAFLD patients. The studies primarily examined eleven phenolic compounds, including turmeric, curcumin, resveratrol, genistein, catechin, green tea extract, hesperidin, and silymarin. Turmeric and curcumin decreased liver enzymes, inflammatory cytokines, lipid profile, insulin resis
Erol Doğan Ö, Karaca Çelik KE, Baş M, Alan EH, Çağın YF · Nutrients · 2024
This study aimed to investigate the effects of the Mediterranean diet (MD), combined with curcumin and resveratrol supplementation, on disease activity, serum inflammatory markers, and quality of life in patients with mild-to-moderate active ulcerative colitis (UC). This study was designed as a prospective multicenter three-arm randomized controlled trial. Participants were randomized to the MD, MD + curcumin, and MD + resveratrol groups. All participants were placed on the MD for 8 weeks. The MD + curcumin group also received 1600 mg/day of curcumin supplementation, whereas the MD + resveratrol group received 500 mg/day of resveratrol supplementation for 8 weeks. Anthropometric measurements, Truelove-Witts Index, Short Form-36, Inflammatory Bowel Disease Questionnaire, Mediterranean Diet Adherence Scale (MEDAS), and laboratory tests were performed at baseline and postintervention. Within-group comparisons showed that MD, MD + curcumin, and MD + resveratrol interventions were effective
K M, Aryan MK, Prabhakaran P, Mulakal JN, Das S S, Im K · Frontiers in allergy · 2024
Allergic rhinitis (AR) is an IgE-mediated reaction to inhaled allergens, and is a prominent health concern affecting approximately 400 million people worldwide. A comprehensive understanding of AR's pathophysiology is imperative for developing novel therapies, especially considering its frequent co-morbidity with asthma and conjunctivitis. The escalating prevalence of AR is correlated with increased urbanization and environmental pollutants, recognized as prominent contributing factors. Dysregulation in immune networks, Th1/Th2 cytokine imbalance, activation of mast cells and eosinophils are implicated in AR progression. Classic AR symptoms include nasal congestion, nasal itching, rhinorrhea, and sneezing which significantly impact the quality of life, social interactions, and workplace productivity.
This randomized, double-blind, placebo-controlled, three-arm, three-sequence study was aimed to assess the efficacy of supplementation of a co-delivery form of turmeric extract with ashwa
Talebpour A, Mohammadifard M, Zare Feyzabadi R, Mahmoudzadeh S, Rezapour H, Saharkhiz M · Physiological reports · 2023 · n=76
Premenstrual syndrome (PMS) and primary dysmenorrhea are common gynecological problems and inflammation may have a role in their etiology. Curcumin is a polyphenolic natural product for which there is increasing evidence of anti-inflammatory and iron chelation effects. This study assessed the effects of curcumin on inflammatory biomarkers and iron profile in young women with PMS and dysmenorrhea. A sample of 76 patients was included in this triple-blind, placebo-controlled clinical trial. Participants were randomly allocated to curcumin (n = 38) and control groups (n = 38). Each participant received one capsule (500 mg of curcuminoid+ piperine, or placebo) daily, from 7 days before until 3 days after menstruation for three consecutive menstrual cycles. Serum iron, ferritin, total iron-binding capacity (TIBC) and high-sensitivity C-reactive protein (hsCRP), as well as white blood cell, lymphocyte, neutrophil, platelet counts, mean platele
Randomized TrialPubMedHigh Quality
Observational Studies(15)
Cohort, case-control, and cross-sectional human studies.
Baharad Y, Engel T, Ben-Horin S · Current opinion in gastroenterology · 2026
This review highlights the emerging role of dietary interventions for Crohn's disease (CD).
An overview of clinical data on dietary strategies for management of CD is presented, including exclusive enteral nutrition, the Crohn's disease exclusion diet (CDED) and the Mediterranean diet, among others. The methodological challenges in performing dietary randomized trials are outlined, including the difficulty in blinding, the multiple components inherent to food interventions and the heterogeneous nature of even 'similar' dietary constituents, collectively making it hard to delineate the responsible mechanism for any observed effect. We also review the data on food supplements explored for this CD treatment, such as vitamin D, omega-3 and combination curcumin-QingDai (CurQD). Novel strategies to integrate personalized nutrition with pharmacologic therapy are discussed and may ultimately improve disease control and patients' long term prognosis and quality of life. Dietary interventions a
Background/Objectives: Allergic diseases are highly prevalent worldwide and represent a significant public health burden. Current therapies mainly alleviate symptoms without addressing underlying immune dysfunction, which has increased interest in nutritional bioactive compounds as preventive or modulatory agents. This review summarizes evidence on omega-3 polyunsaturated fatty acids, vitamin D, curcumin, ginger bioactives, quercetin, and epigallocatechin gallate (EGCG) in allergy prevention and management. Methods: A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science up to July 2025, including preclinical and clinical studies reporting immunological, mechanistic, and clinical outcomes. Results: Omega-3 fatty acids modulate Th2 responses, promote regulatory T cells, and generate specialized pro-resolving mediators, with modest clinical benefits observed in pregnancy and early life. Vitamin D contributes to immune tolerance and epithelial integrity, alth
Jahdkaran M, Asri N, Houri H, Baghaei K, Esmaily H, Sapone A · Molecular biology reports · 2025
The primary treatment for Celiac disease (CeD) is a gluten-free diet (GFD), which presents challenges. Studies on the anti-inflammatory properties of Curcumin, Quercetin, Vitamin D, Zinc, and Eicosapentaenoic acid (EPA) offer hope for patients. This study evaluated their effects on immune reactivity in gliadin-stimulated Caco-2 cells.
Cells were treated with pepsin trypsin-digested gliadin (PT-G) and exposed to these compounds individually and in combinations using the n-1 method. Gene expressions of TNF-α, NF-κB, STAT-3, ZO-1, and Occludin were analyzed via qPCR, while IL-6 and IL-10 protein levels were measured using ELISA. Results showed a significant decrease in NF-κB gene expression for Curcumin (P < 0.01), Quercetin (P < 0.001), Vitamin D (P < 0.01), Zinc (P < 0.01), EPA (P < 0.001), and CQEDZ (P < 0.05). IL-6 levels increased significantly with Curcumin (P
Observational StudyPubMedLow Quality
Animal Studies(2)
Preclinical animal research — not a substitute for human evidence.
Demir E, Koten M, Keskin FEU, Eryıldız C, Güven SG · Allergologia et immunopathologia · 2026
Curcumin, a flavonoid derived from turmeric, has demonstrated antioxidant, anti-inflammatory, and antiallergic effects. This study evaluated the therapeutic efficacy of intranasal curcumin in an allergic rhinitis (AR) rat model. Forty rats were randomized into four groups: a sham control, an AR model with no treatment (negative control), an AR model treated with intranasal mometasone furoate (positive control), and an AR model treated with intranasal curcumin. Allergic symptoms (sneezing, itching, nasal discharge) were evaluated by both unblinded and blinded observers. Serum Ovalbumin (OVA)-specific IgE levels were measured using ELISA. Nasal mucosal histopathology (edema, cilia loss, goblet cell hyperplasia, inflammation, eosinophilia) was assessed by light microscopy. Intranasal curcumin significantly improved histopathological findings and reduced allergic symptoms, with efficacy comparable to steroid treatment. It alleviates AR symptoms and inflammation, suggesting a promising, low
Demir E, Koten M, Keskin FEU, Eryıldız C, Güven SG · Allergologia et immunopathologia · 2026
Curcumin, a flavonoid derived from turmeric, has demonstrated antioxidant, anti-inflammatory, and anti-allergic effects. This study evaluated the therapeutic efficacy of intranasal curcumin in an allergic rhinitis (AR) rat model. Forty rats were randomized into five groups: a Sham control, an AR model with no treatment (negative control), an AR model treated with intranasal mometasone furoate (positive control), and an AR model treated with intranasal curcumin. Allergic symptoms (sneezing, itching, nasal discharge) were evaluated by both unblinded and blinded observers. Serum ovalbumin (OVA)-specific IgE levels were measured using ELISA. Nasal mucosal histopathology (edema, cilia loss, goblet cell hyperplasia, inflammation, eosinophilia) was assessed by light microscopy. Intranasal curcumin significantly improved histopathological findings and reduced allergic symptoms, with efficacy comparable to steroid treatment. Intranasal curcumin alleviated allergic rhinitis symptoms and inflamma
Animal StudyPubMedLow Quality
Clinical Trial Registries(11)
Registered ongoing or completed trials (ClinicalTrials.gov).
The investigators aim to evaluate the effect of curcumin and virgin coconut oil extract supplementation on people with type 2 DM, including blood glucose, HbA1c levels, inflammation, body weight and insulin resistance evaluation
The goal of this clinical trial is to investigate The effects of an anti-inflammatory diet with or without curcumin supplementation on anthropometric measurements, concentrations of thyroid hormones, anti-TPO, and systemic inflammation in plasma and NFK-B in peripheral blood mononuclear cells in patients with Hashimoto.
The main questions it aims to answer are:
1. Does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the changes in anthropometric measurements (weight, body mass index, BMI, waist circumference, waist-to-hip ratio) in patients with Hashimoto's disease?
2. Does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the changes in the serum concentration of thyroid hormones (T3, T4, TSH) in patients with Hashimoto's disease?
3. Does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the change of Anti-TPO concentration in patients with Hashimoto's disease?
4. Does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the changes in systemic inflammation indicators (hs-CRP, IL-6) in plasma and NF-κB in peripheral blood mononuclear cells in patients with Hashimoto's disease?
This study will investigate the effects of curcumin on the structure/function of the body by investigating whether targeted improvement of intestinal barrier function by supplementation with oral curcumin will result in attenuation of lipopolysaccharide (LPS) translocation and/or intestinal inflammation.
Clinical TrialClinicalTrials.govModerate Quality
Limitations: The primary limitation is the lack of specific, high-quality human clinical trials for many of the linked ailments. Many studies are preclinical or pilot studies, which do not provide sufficient evidence for definitive conclusions. Bioavailability of curcumin is also a known challenge, which can impact the interpretation of study results.
This page is educational. Statements use phrases like "may support" and "has been studied for"because no remedy here is approved to cure, treat, or reverse any condition. Discussion happens on the ailment pages — community statistics here are derived from those reports. Always consult a qualified clinician.
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